Chen, Shuibing

Publications

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selected publications

A Targetable Pathway to Eliminate TRA-1-60+/TRA-1-81+ Chemoresistant Cancer Cells. Journal of molecular cell biology. 2023 Academic Article GET IT
Functional interrogation of twenty type 2 diabetes-associated genes using isogenic hESC-derived β-like cells. bioRxiv : the preprint server for biology. 2023 Article GET IT
Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy. Cell stem cell. 2023 Academic Article GET IT
Times cited: 1
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation. Cell stem cell. 2023 Review GET IT
Times cited: 1
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes. Nature cell biology. 2023 Academic Article GET IT
A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection. Nature cell biology. 2023 Academic Article GET IT
Times cited: 413
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children. Science (New York, N.Y.). 2023 Academic Article GET IT
Times cited: 13
Selective targeting of visceral adiposity by polycation nanomedicine. Nature nanotechnology. 2022 Academic Article GET IT
Times cited: 4
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication. Science signaling. 2022 Academic Article GET IT
Times cited: 8
Dual-Reporter System for Real-Time Monitoring of SARS-CoV-2 Main Protease Activity in Live Cells Enables Identification of an Allosteric Inhibition Path. ACS bio & med chem Au. 2022 Academic Article GET IT
Times cited: 195
A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell stem cell. 2022 Academic Article GET IT
Times cited: 111
Druggable targets and therapeutic development for COVID-19. Frontiers in chemistry. 2022 Review GET IT
Times cited: 271
Organoids as tools for fundamental discovery and translation-a Keystone Symposia report. Annals of the New York Academy of Sciences. 2022 Academic Article GET IT
Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis. Cell stem cell. 2022 Comment GET IT
Times cited: 1
Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy. iScience. 2022 Academic Article GET IT
Times cited: 19
Human organoid models to study SARS-CoV-2 infection. Nature methods. 2022 Review GET IT
Times cited: 35
Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging. Science advances. 2022 Academic Article GET IT
Times cited: 2
A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells. iScience. 2022 Academic Article GET IT
Times cited: 4613
SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells. Circulation research. 2022 Academic Article GET IT
Times cited: 23
Comments on 'An airway organoid-based screen identifies a role for the HIF1α‒glycolysis axis in SARS-CoV-2 infection'. Journal of molecular cell biology. 2022 Comment GET IT
Times cited: 1
Retraction Note to: Transient Activation of Reprogramming Transcription Factors Using Protein Transduction Facilitates Conversion of Human Fibroblasts Toward Cardiomyocyte-Like Cells. Molecular biotechnology. 2022 Academic Article GET IT
Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation. Cell reports. 2021 Academic Article GET IT
Times cited: 4
Mechanisms of Lung Injury Induced by SARS-CoV-2 Infection. Physiology (Bethesda, Md.). 2021 Review GET IT
Times cited: 8
An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection. Cell reports. 2021 Academic Article GET IT
Times cited: 26
Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2. Stem cell reports. 2021 Article GET IT
Times cited: 3
Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry. Molecular medicine (Cambridge, Mass.). 2021 Academic Article GET IT
Times cited: 8
Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2. Stem cell reports. 2021 Academic Article GET IT
Times cited: 26
SARS-CoV-2 Infects Syncytiotrophoblast and Activates Inflammatory Responses in the Placenta. bioRxiv : the preprint server for biology. 2021 Article GET IT
SARS-CoV-2 Infection Causes Dopaminergic Neuron Senescence. Research square. 2021 Article GET IT
SARS-CoV-2 infection induces beta cell transdifferentiation. Cell metabolism. 2021 Academic Article GET IT
Times cited: 90
The small molecule DIPQUO promotes osteogenic differentiation via inhibition of glycogen synthase kinase 3-beta signaling. The Journal of biological chemistry. 2021 Academic Article GET IT
Times cited: 3
An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts. Circulation research. 2021 Academic Article GET IT
Times cited: 25
Phenotypic technologies in stem cell biology. Cell chemical biology. 2021 Review GET IT
Times cited: 4
Human pluripotent stem cell-based organoids and cell platforms for modelling SARS-CoV-2 infection and drug discovery. Stem cell research. 2021 Academic Article GET IT
Times cited: 10
The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro. bioRxiv : the preprint server for biology. 2020 Article GET IT
SARS-CoV-2 Infected Cardiomyocytes Recruit Monocytes by Secreting CCL2. Research square. 2020 Article GET IT
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids. Nature. 2020 Academic Article GET IT
Times cited: 274
Modeling cancer progression using human pluripotent stem cell-derived cells and organoids. Stem cell research. 2020 Review GET IT
Times cited: 6
Modeling polymorphic ventricular tachycardia at rest using patient-specific induced pluripotent stem cell-derived cardiomyocytes. EBioMedicine. 2020 Academic Article GET IT
Times cited: 14
Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2. Research square. 2020 Article GET IT
Modeling endodermal organ development and diseases using human pluripotent stem cell-derived organoids. Journal of molecular cell biology. 2020 Review GET IT
Times cited: 3
A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes. Cell stem cell. 2020 Academic Article GET IT
Times cited: 37
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell stem cell. 2020 Academic Article GET IT
Times cited: 420
Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids. bioRxiv : the preprint server for biology. 2020 Article GET IT
A human embryonic stem cell reporter line for monitoring chemical-induced cardiotoxicity. Cardiovascular research. 2020 Academic Article GET IT
Times cited: 9
Organoid-based chemical approach to dissect the mechanism controlling cellular dynamics. Journal of molecular cell biology. 2019 Academic Article GET IT
Times cited: 1
Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells. Nature communications. 2019 Academic Article GET IT
Times cited: 20
CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells. Scientific reports. 2019 Academic Article GET IT
Times cited: 12
Author Correction: A recellularized human colon model identifies cancer driver genes. Nature biotechnology. 2019 Article GET IT
Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation. Nature genetics. 2019 Academic Article GET IT
Times cited: 58
Discovery of a Small Molecule Promoting Mouse and Human Osteoblast Differentiation via Activation of p38 MAPK-β. Cell chemical biology. 2019 Academic Article GET IT
Times cited: 13
Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors. Neuron. 2019 Academic Article GET IT
Times cited: 43
Screening-Based Chemical Approaches to Unravel Stem Cell Biology. Stem cell reports. 2018 Review GET IT
Times cited: 6
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival. Nature communications. 2018 Academic Article GET IT
Times cited: 20
PRMT5-mediated regulation of developmental myelination. Nature communications. 2018 Academic Article GET IT
Times cited: 53
Discovery of a drug candidate for GLIS3-associated diabetes. Nature communications. 2018 Academic Article GET IT
Times cited: 39
Male germ cells support long-term propagation of Zika virus. Nature communications. 2018 Academic Article GET IT
Times cited: 53
Derivation and characterization of a UCP1 reporter human ES cell line. Stem cell research. 2018 Academic Article GET IT
Times cited: 5
Corrigendum: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing. Nature medicine. 2018 Article GET IT
Times cited: 5
A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages. Cell stem cell. 2017 Academic Article GET IT
Times cited: 110
ROCKII inhibition promotes the maturation of human pancreatic beta-like cells. Nature communications. 2017 Academic Article GET IT
Times cited: 60
An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis. Cell reports. 2017 Academic Article GET IT
Times cited: 68
High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain. Cell stem cell. 2017 Academic Article GET IT
Times cited: 162
Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing. Nature medicine. 2017 Academic Article GET IT
Times cited: 226
Transient Activation of Reprogramming Transcription Factors Using Protein Transduction Facilitates Conversion of Human Fibroblasts Toward Cardiomyocyte-Like Cells. Molecular biotechnology. 2017 Academic Article GET IT
Times cited: 10
Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E. Cell reports. 2017 Academic Article GET IT
Times cited: 25
Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development. Cell stem cell. 2017 Academic Article GET IT
Times cited: 104
Efficient Generation of Cardiac Purkinje-like Cells from Embryonic Stem Cells by Activating cAMP Signaling. Current protocols in stem cell biology. 2017 Academic Article GET IT
Times cited: 4
Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells. Scientific reports. 2017 Academic Article GET IT
Times cited: 39
An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery. Cell stem cell. 2016 Academic Article GET IT
Times cited: 80
A recellularized human colon model identifies cancer driver genes. Nature biotechnology. 2016 Academic Article GET IT
Times cited: 72
Dynamic self-organization of microwell-aggregated cellular mixtures. Soft matter. 2016 Academic Article GET IT
Times cited: 24
Multifunctional in vivo imaging of pancreatic islets during diabetes development. Journal of cell science. 2016 Academic Article GET IT
Times cited: 20
Discovery of a Small-Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation. Cell reports. 2016 Academic Article GET IT
Times cited: 16
Modeling Cystic Fibrosis Using Pluripotent Stem Cell-Derived Human Pancreatic Ductal Epithelial Cells. Stem cells translational medicine. 2016 Academic Article GET IT
Times cited: 37
Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease. Nature. 2016 Academic Article GET IT
Times cited: 208
Efficient Generation of Cardiac Purkinje Cells from ESCs by Activating cAMP Signaling. Stem cell reports. 2015 Academic Article GET IT
Times cited: 27
Endothelial cells control pancreatic cell fate at defined stages through EGFL7 signaling. Stem cell reports. 2015 Academic Article GET IT
Times cited: 31
Nanofibrous microposts and microwells of controlled shapes and their hybridization with hydrogels for cell encapsulation. ACS applied materials & interfaces. 2014 Letter GET IT
Times cited: 28
Pluripotent stem cell-derived pancreatic β-cells: potential for regenerative medicine in diabetes. Regenerative medicine. 2012 Review GET IT
Times cited: 6
Cardiac glycosides are potent inhibitors of interferon-β gene expression. Nature chemical biology. 2010 Academic Article GET IT
Times cited: 42
Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 462
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell stem cell. 2009 Academic Article GET IT
Times cited: 353
A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nature chemical biology. 2009 Academic Article GET IT
Times cited: 421
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nature biotechnology. 2008 Academic Article GET IT
Times cited: 1133
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell stem cell. 2007 Academic Article GET IT
Times cited: 274
Reversine increases the plasticity of lineage-committed mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 84
Genetic incorporation of unnatural amino acids into proteins in mammalian cells. Nature methods. 2007 Academic Article GET IT
Times cited: 303
Self-renewal of embryonic stem cells by a small molecule. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 269
Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 383
Exploring stem cell biology with small molecules. Molecular bioSystems. 2005 Review GET IT
Times cited: 38
Dedifferentiation of lineage-committed cells by a small molecule. Journal of the American Chemical Society. 2004 Academic Article GET IT
Times cited: 274
Negative-ion electrospray ionization tandem mass spectrometry of N-phosphoryl amino acids and dipeptides. Rapid communications in mass spectrometry : RCM. 2002 Academic Article GET IT
Times cited: 14

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Research

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Funding awarded

Decode the Impact of SARS-CoV-2 on Human Pancreas awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2021 - 2024
Determining the Intrinsic and Environmental Signal Contributing to Early T1D Progression awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2020 - 2024
A High Content Chemical Screen to Identify the Drug Candidates Promoting Human Beta Cell Proliferation awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2020 - 2024
Identifying therapeutic vulnerabilities for COVID-19 using stem cell-derived tissues awarded by Tri-Institutional Stem Cell Initiative (Weill Cornell) Principal Investigator 2022 - 2023
Addgene 702995 awarded by Addgene, Inc. Principal Investigator 2022 - 2023
Metallothionein 1E as a Central Regulator of Human Pancreatic Beta Cell Function and Survival awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2019 - 2023

Studies of the initiation and progression of small cell lung cancer using cells derived by differentiation from human pluripotent stem cells awarded by National Cancer Institute Co-Investigator 2018 - 2024

A hPSC-based multiplex platform to interrogate diabetogenic interactions of T2D-associated genes in human pancreatic beta-cells. awarded by American Diabetes Association, Inc. Key Personnel 2022 - 2025

Functional Interactions Between MAPKs and SARS-CoV-2 Infection awarded by National Heart, Lung, & Blood Institute Principal Investigator Subaward 2023 - 2028

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Background

education and training

Ph.D., Kellogg School of Science and Technology, The Scripps Research Institute 2006
M.S., Tsinghua University (China) 2002
B.S., Tsinghua University (China) 1999

VIVO Weill Cornell Medical College

Shuibing Chen Professor of Chemical Biology in Surgery

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email