Rinne, Sara

Publications

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selected publications

Efficacy of HER2-Targeted Intraperitoneal ²²⁵Ac α-Pretargeted Radioimmunotherapy for Small-Volume Ovarian Peritoneal Carcinomatosis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2023 Academic Article GET IT
Phase I Trial of [^99mTc]Tc-maSSS-PEG₂-RM26, a Bombesin Analogue Antagonistic to Gastrin-Releasing Peptide Receptors (GRPRs), for SPECT Imaging of GRPR Expression in Malignant Tumors. Cancers. 2023 Academic Article GET IT
Times cited: 172
Feasibility of Co-Targeting HER3 and EpCAM Using Seribantumab and DARPin-Toxin Fusion in a Pancreatic Cancer Xenograft Model. International journal of molecular sciences. 2023 Academic Article GET IT
Times cited: 310
Preclinical Characterisation of PSMA/GRPR-Targeting Heterodimer [⁶⁸Ga]Ga-BQ7812 for PET Diagnostic Imaging of Prostate Cancer: A Step towards Clinical Translation. Cancers. 2023 Academic Article GET IT
Times cited: 51
Preclinical Evaluation of a New Format of ⁶⁸Ga- and ¹¹¹In-Labeled Affibody Molecule Z_IGF-1R:4551 for the Visualization of IGF-1R Expression in Malignant Tumors Using PET and SPECT. Pharmaceutics. 2022 Academic Article GET IT
Times cited: 31
Targeting Tumor Cells Overexpressing the Human Epidermal Growth Factor Receptor 3 with Potent Drug Conjugates Based on Affibody Molecules. Biomedicines. 2022 Academic Article GET IT
Times cited: 7
Design, Synthesis, and Evaluation of Linker-Optimised PSMA-Targeting Radioligands. Pharmaceutics. 2022 Academic Article GET IT
Times cited: 137
HER3 PET Imaging: ⁶⁸Ga-Labeled Affibody Molecules Provide Superior HER3 Contrast to ⁸⁹Zr-Labeled Antibody and Antibody-Fragment-Based Tracers. Cancers. 2021 Academic Article GET IT
Times cited: 80
Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1. Cancers. 2021 Academic Article GET IT
Times cited: 245
PET and SPECT Imaging of the EGFR Family (RTK Class I) in Oncology. International journal of molecular sciences. 2021 Review GET IT
Times cited: 14
Preclinical Evaluation of ^99mTc-ZHER2:41071, a Second-Generation Affibody-Based HER2-Visualizing Imaging Probe with a Low Renal Uptake. International journal of molecular sciences. 2021 Academic Article GET IT
Times cited: 11
The Use of a Non-Conventional Long-Lived Gallium Radioisotope ⁶⁶Ga Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR:2377 Affibody Molecule. Pharmaceutics. 2021 Academic Article GET IT
Times cited: 126
⁶⁶Ga-PET-imaging of GRPR-expression in prostate cancer: production and characterization of [⁶⁶Ga]Ga-NOTA-PEG₂-RM26. Scientific reports. 2021 Academic Article GET IT
Times cited: 8
Preclinical Evaluation of ^99mTc-Labeled GRPR Antagonists maSSS/SES-PEG₂-RM26 for Imaging of Prostate Cancer. Pharmaceutics. 2021 Academic Article GET IT
Times cited: 91
Preclinical Evaluation of the Copper-64 Labeled GRPR-Antagonist RM26 in Comparison with the Cobalt-55 Labeled Counterpart for PET-Imaging of Prostate Cancer. Molecules (Basel, Switzerland). 2020 Academic Article GET IT
Times cited: 3
Preclinical Evaluation of the GRPR-Targeting Antagonist RM26 Conjugated to the Albumin-Binding Domain for GRPR-Targeting Therapy of Cancer. Pharmaceutics. 2020 Academic Article GET IT
Times cited: 17
Investigation of a Pharmacological Approach for Reduction of Renal Uptake of Radiolabeled ADAPT Scaffold Protein. Molecules (Basel, Switzerland). 2020 Academic Article GET IT
Times cited: 4
Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer-Optimization of the Affinity towards PSMA by Linker Modification in Murine Model. Pharmaceutics. 2020 Academic Article GET IT
Times cited: 60
Evaluating the Therapeutic Efficacy of Mono- and Bivalent Affibody-Based Fusion Proteins Targeting HER3 in a Pancreatic Cancer Xenograft Model. Pharmaceutics. 2020 Academic Article GET IT
Times cited: 10
Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1. International journal of molecular sciences. 2020 Academic Article GET IT
Times cited: 13
Benefit of Later-Time-Point PET Imaging of HER3 Expression Using Optimized Radiocobalt-Labeled Affibody Molecules. International journal of molecular sciences. 2020 Academic Article GET IT
Times cited: 7
Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules. International journal of molecular sciences. 2020 Academic Article GET IT
Times cited: 6
On the prevention of kidney uptake of radiolabeled DARPins. EJNMMI research. 2020 Academic Article GET IT
Times cited: 70
Increase in negative charge of ⁶⁸Ga/chelator complex reduces unspecific hepatic uptake but does not improve imaging properties of HER3-targeting affibody molecules. Scientific reports. 2019 Academic Article GET IT
Times cited: 13
Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26. Scientific reports. 2019 Academic Article GET IT
Times cited: 12
Bispecific GRPR-Antagonistic Anti-PSMA/GRPR Heterodimer for PET and SPECT Diagnostic Imaging of Prostate Cancer. Cancers. 2019 Academic Article GET IT
Times cited: 87
Incorporation of a Hydrophilic Spacer Reduces Hepatic Uptake of HER2-Targeting Affibody-DM1 Drug Conjugates. Cancers. 2019 Academic Article GET IT
Times cited: 49
Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer. Pharmaceutics. 2019 Academic Article GET IT
Times cited: 13
Indirect Radioiodination of DARPin G3 Using N-succinimidyl-Para-Iodobenzoate Improves the Contrast of HER2 Molecular Imaging. International journal of molecular sciences. 2019 Academic Article GET IT
Times cited: 19
Trastuzumab cotreatment improves survival of mice with PC-3 prostate cancer xenografts treated with the GRPR antagonist ¹⁷⁷ Lu-DOTAGA-PEG₂ -RM26. International journal of cancer. 2019 Academic Article GET IT
Times cited: 22
Improved contrast of affibody-mediated imaging of HER3 expression in mouse xenograft model through co-injection of a trivalent affibody for in vivo blocking of hepatic uptake. Scientific reports. 2019 Academic Article GET IT
Times cited: 7
Molecular Design of HER3-Targeting Affibody Molecules: Influence of Chelator and Presence of HEHEHE-Tag on Biodistribution of ⁶⁸Ga-Labeled Tracers. International journal of molecular sciences. 2019 Academic Article GET IT
Times cited: 20
Comparison of tumor‑targeting properties of directly and indirectly radioiodinated designed ankyrin repeat protein (DARPin) G3 variants for molecular imaging of HER2. International journal of oncology. 2019 Academic Article GET IT
Times cited: 22
Optimization of HER3 expression imaging using affibody molecules: Influence of chelator for labeling with indium-111. Scientific reports. 2019 Academic Article GET IT
Times cited: 16
Influence of Molecular Design on the Targeting Properties of ABD-Fused Mono- and Bi-Valent Anti-HER3 Affibody Therapeutic Constructs. Cells. 2018 Academic Article GET IT
Times cited: 72
Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model. Theranostics. 2018 Academic Article GET IT
Times cited: 22
Evaluation of the Therapeutic Potential of a HER3-Binding Affibody Construct TAM-HER3 in Comparison with a Monoclonal Antibody, Seribantumab. Molecular pharmaceutics. 2018 Academic Article GET IT
Times cited: 17
Development of an optimal imaging strategy for selection of patients for affibody-based PNA-mediated radionuclide therapy. Scientific reports. 2018 Academic Article GET IT
Times cited: 9
Evaluation of a radiocobalt-labelled affibody molecule for imaging of human epidermal growth factor receptor 3 expression. International journal of oncology. 2017 Academic Article GET IT
Times cited: 10

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Research

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Funding awarded

DOTA-based pre-targeting of alpha emitters awarded by National Cancer Institute Key Personnel 2022 - 2023

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Background

education and training

Ph.D., Upsala University (Sweden) 2022
M.M.S., Upsala University (Sweden) 2017
B.S., University of Lubeck (Germany) 2015

Contact

full name

Sara Rinne

primary email

ssr4003@med.cornell.edu

VIVO Weill Cornell Medical College

Sara Rinne Postdoctoral Associate in Radiology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email