Pascual, Virginia

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selected publications

Association of Juvenile Dermatomyositis Disease Activity With the Expansion of Blood Memory B and T Cell Subsets Lacking Follicular Markers. Arthritis & rheumatology (Hoboken, N.J.). 2023 Academic Article GET IT
Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults. medRxiv : the preprint server for health sciences. 2023 Article GET IT
Systemic Lupus Erythematosus Pathogenesis: Interferon and Beyond. Annual review of immunology. 2023 Review GET IT
Times cited: 2
mTORC1 links pathology in experimental models of Still's disease and macrophage activation syndrome. Nature communications. 2022 Academic Article GET IT
Times cited: 3
Perception of risk and impact of the COVID-19 pandemic on patients with rheumatic diseases: a case-control study. Clinical rheumatology. 2022 Academic Article GET IT
TLR7 gain-of-function genetic variation causes human lupus. Nature. 2022 Academic Article GET IT
Times cited: 80
The Interleukin-1 Receptor-Associated Kinase 4 Inhibitor PF-06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial. Arthritis & rheumatology (Hoboken, N.J.). 2021 Academic Article GET IT
Times cited: 21
Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE. Cell. 2021 Academic Article GET IT
Times cited: 47
Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data. Nature communications. 2021 Academic Article GET IT
Times cited: 12
Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses. The Journal of experimental medicine. 2021 Review GET IT
Times cited: 31
Breaching self-tolerance by targeting the gatekeeper. The Journal of experimental medicine. 2021 Comment GET IT
Times cited: 1
Single Cell Analysis of Blood Mononuclear Cells Stimulated Through Either LPS or Anti-CD3 and Anti-CD28. Frontiers in immunology. 2021 Academic Article GET IT
Times cited: 19
Extracellular vesicle and particle isolation from human and murine cell lines, tissues, and bodily fluids. STAR protocols. 2020 Academic Article GET IT
Times cited: 8
Mass Cytometry Defines Virus-Specific CD4⁺ T Cells in Influenza Vaccination. ImmunoHorizons. 2020 Academic Article GET IT
Times cited: 2
The immune roadmap for understanding multi-system inflammatory syndrome in children: opportunities and challenges. Nature medicine. 2020 Academic Article GET IT
Times cited: 29
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. Cell. 2020 Academic Article GET IT
Times cited: 477
Mapping systemic lupus erythematosus heterogeneity at the single-cell level. Nature immunology. 2020 Academic Article GET IT
Times cited: 118
Unique Sjögren's syndrome patient subsets defined by molecular features. Rheumatology (Oxford, England). 2020 Academic Article GET IT
Times cited: 34
Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus. Nature medicine. 2020 Academic Article GET IT
Times cited: 80
CX3CL1-CX3CR1 Axis: A New Player in Coeliac Disease Pathogenesis. Nutrients. 2019 Academic Article GET IT
Times cited: 5
Myeloablation followed by autologous stem cell transplantation normalises systemic sclerosis molecular signatures. Annals of the rheumatic diseases. 2019 Academic Article GET IT
Times cited: 38
Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases. Nature communications. 2019 Academic Article GET IT
Times cited: 34
Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus. Nature communications. 2019 Academic Article GET IT
Times cited: 63
Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy. The Journal of experimental medicine. 2019 Academic Article GET IT
Times cited: 38
OX40L/OX40 axis impairs follicular and natural Treg function in human SLE. JCI insight. 2018 Academic Article GET IT
Times cited: 36
A CD4⁺ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate. Nature medicine. 2018 Academic Article GET IT
Times cited: 142
Expression patterns common and unique to ulcerative colitis and celiac disease. Annals of human genetics. 2018 Academic Article GET IT
Times cited: 11
IL1 Receptor Antagonist Controls Transcriptional Signature of Inflammation in Patients with Metastatic Breast Cancer. Cancer research. 2018 Academic Article GET IT
Times cited: 87
Interleukin-1 in monocyte activation phenotypes in systemic juvenile idiopathic arthritis: Observations from a clinical trial of rilonacept, an interleukin-1 inhibitor. Clinical immunology (Orlando, Fla.). 2018 Academic Article GET IT
Times cited: 8
Whole blood transcriptional profiles as a prognostic tool in complete and incomplete Kawasaki Disease. PloS one. 2018 Academic Article GET IT
Times cited: 27
Evaluation of T cells in blood after a short gluten challenge for coeliac disease diagnosis. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2018 Academic Article GET IT
Times cited: 14
A multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis. The Journal of experimental medicine. 2017 Academic Article GET IT
Times cited: 30
Constitutive resistance to viral infection in human CD141⁺ dendritic cells. Science immunology. 2017 Academic Article GET IT
Times cited: 75
Open-Label, Phase II Study to Assess the Efficacy and Safety of Canakinumab Treatment in Active Hyperimmunoglobulinemia D With Periodic Fever Syndrome. Arthritis & rheumatology (Hoboken, N.J.). 2017 Academic Article GET IT
Times cited: 34
Influenza vaccines differentially regulate the interferon response in human dendritic cell subsets. Science translational medicine. 2017 Academic Article GET IT
Times cited: 23
Modular transcriptional repertoire analyses identify a blood neutrophil signature as a candidate biomarker for lupus nephritis. Rheumatology (Oxford, England). 2017 Academic Article GET IT
Times cited: 54
Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics. Annual review of immunology. 2017 Review GET IT
Times cited: 55
The Transcriptional Signature of Active Tuberculosis Reflects Symptom Status in Extra-Pulmonary and Pulmonary Tuberculosis. PloS one. 2016 Academic Article GET IT
Times cited: 57
Transcriptional Repression of IFN Regulatory Factor 7 by MYC Is Critical for Type I IFN Production in Human Plasmacytoid Dendritic Cells. Journal of immunology (Baltimore, Md. : 1950). 2016 Academic Article GET IT
Times cited: 28
Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients. Cell. 2016 Academic Article GET IT
Times cited: 71
Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus. The Journal of experimental medicine. 2016 Academic Article GET IT
Times cited: 281
A 380-gene meta-signature of active tuberculosis compared with healthy controls. The European respiratory journal. 2016 Letter GET IT
Times cited: 36
Rhinovirus Detection in Symptomatic and Asymptomatic Children: Value of Host Transcriptome Analysis. American journal of respiratory and critical care medicine. 2016 Academic Article GET IT
Times cited: 76
Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients. Cell. 2016 Academic Article GET IT
Times cited: 385
Analysis of Transcriptional Signatures in Response to Listeria monocytogenes Infection Reveals Temporal Changes That Result from Type I Interferon Signaling. PloS one. 2016 Academic Article GET IT
Times cited: 5
Standardizing Flow Cytometry Immunophenotyping Analysis from the Human ImmunoPhenotyping Consortium. Scientific reports. 2016 Academic Article GET IT
Times cited: 185
Different Gene Expression Signatures in Children and Adults with Celiac Disease. PloS one. 2016 Academic Article GET IT
Times cited: 20
Grancalcin (GCA) modulates Toll-like receptor 9 (TLR9) mediated signaling through its direct interaction with TLR9. European journal of immunology. 2016 Academic Article GET IT
Times cited: 8
Rate and Clinical Presentation of Macrophage Activation Syndrome in Patients With Systemic Juvenile Idiopathic Arthritis Treated With Canakinumab. Arthritis & rheumatology (Hoboken, N.J.). 2016 Academic Article GET IT
Times cited: 81
Antibodies to Mitotic Apparatus: New Association With Cholestatic Liver Disease. The American journal of gastroenterology. 2015 Letter GET IT
Times cited: 4
Expansion of inflammatory innate lymphoid cells in patients with common variable immune deficiency. The Journal of allergy and clinical immunology. 2015 Academic Article GET IT
Times cited: 56
The Blood Transcriptome of Experimental Melioidosis Reflects Disease Severity and Shows Considerable Similarity with the Human Disease. Journal of immunology (Baltimore, Md. : 1950). 2015 Academic Article GET IT
Times cited: 18
Response to Infliximab in Crohn's Disease: Genetic Analysis Supporting Expression Profile. Mediators of inflammation. 2015 Academic Article GET IT
Times cited: 16
OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response. Immunity. 2015 Academic Article GET IT
Times cited: 167
The E3 ubiquitin ligase Itch inhibits p38α signaling and skin inflammation through the ubiquitylation of Tab1. Science signaling. 2015 Academic Article GET IT
Times cited: 37
Identification of a pathogenic variant in TREX1 in early-onset cerebral systemic lupus erythematosus by Whole-exome sequencing. 2014 GET IT
Times cited: 50
Transcriptional fingerprints of antigen-presenting cell subsets in the human vaginal mucosa and skin reflect tissue-specific immune microenvironments. Genome medicine. 2014 Academic Article GET IT
Times cited: 39
A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4. Nature immunology. 2014 Academic Article GET IT
Times cited: 53
Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines. Nature communications. 2014 Academic Article GET IT
Times cited: 44
Gene expression analysis of children with acute hematogenous osteomyelitis caused by Methicillin-resistant Staphylococcus aureus: correlation with clinical severity of illness. PloS one. 2014 Academic Article GET IT
Times cited: 13
Modular transcriptional repertoire analyses of adults with systemic lupus erythematosus reveal distinct type I and type II interferon signatures. Arthritis & rheumatology (Hoboken, N.J.). 2014 Academic Article GET IT
Times cited: 243
Identification of the key differential transcriptional responses of human whole blood following TLR2 or TLR4 ligation in-vitro. PloS one. 2014 Academic Article GET IT
Times cited: 11
IFN priming is necessary but not sufficient to turn on a migratory dendritic cell program in lupus monocytes. Journal of immunology (Baltimore, Md. : 1950). 2014 Academic Article GET IT
Times cited: 29
Inflammatory bowel disease and celiac disease: overlaps and differences. World journal of gastroenterology. 2014 Review GET IT
Times cited: 69
Reprogramming tumor-infiltrating dendritic cells for CD103+ CD8+ mucosal T-cell differentiation and breast cancer rejection. Cancer immunology research. 2014 Academic Article GET IT
Times cited: 61
Early-onset stroke and vasculopathy associated with mutations in ADA2. The New England journal of medicine. 2014 Academic Article GET IT
Times cited: 543
Differences in antibody responses between trivalent inactivated influenza vaccine and live attenuated influenza vaccine correlate with the kinetics and magnitude of interferon signaling in children. The Journal of infectious diseases. 2014 Academic Article GET IT
Times cited: 52
RNA recognition by human TLR8 can lead to autoimmune inflammation. The Journal of experimental medicine. 2013 Academic Article GET IT
Times cited: 124
Human plasma cells express granzyme B. European journal of immunology. 2013 Academic Article GET IT
Times cited: 24
Systems approaches to human autoimmune diseases. Current opinion in immunology. 2013 Review GET IT
Times cited: 11
Interferon signature in the blood in inflammatory common variable immune deficiency. PloS one. 2013 Academic Article GET IT
Times cited: 58
Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers. PloS one. 2013 Academic Article GET IT
Times cited: 210
Current perspectives on systems immunology approaches to rheumatic diseases. Arthritis and rheumatism. 2013 Review GET IT
Times cited: 15
Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines. Immunity. 2013 Academic Article GET IT
Times cited: 218
Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-β. Immunity. 2013 Academic Article GET IT
Times cited: 141
Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination. Science translational medicine. 2013 Academic Article GET IT
Times cited: 447
IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans. Blood. 2013 Academic Article GET IT
Times cited: 130
Clinical and transcriptional response to the long-acting interleukin-1 blocker canakinumab in Blau syndrome-related uveitis. 2013 GET IT
Times cited: 108
Signature MicroRNA expression patterns identified in humans with 22q11.2 deletion/DiGeorge syndrome. Clinical immunology (Orlando, Fla.). 2013 Academic Article GET IT
Times cited: 51
Neutrophils come of age in chronic inflammation. Current opinion in immunology. 2012 Review GET IT
Times cited: 59
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. Nature immunology. 2012 Academic Article GET IT
Times cited: 337
Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy. PloS one. 2012 Academic Article GET IT
Times cited: 155
From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines. Nature immunology. 2012 Review GET IT
Times cited: 305
Macrophages induce differentiation of plasma cells through CXCL10/IP-10. The Journal of experimental medicine. 2012 Academic Article GET IT
Times cited: 59
Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation. The Journal of experimental medicine. 2012 Academic Article GET IT
Times cited: 86
Host immune transcriptional profiles reflect the variability in clinical disease manifestations in patients with Staphylococcus aureus infections. PloS one. 2012 Academic Article GET IT
Times cited: 77
Tracking interferon in autoimmunity. Immunity. 2012 Comment GET IT
Times cited: 6
Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Science translational medicine. 2011 Academic Article GET IT
Times cited: 990
Interferon-α induces unabated production of short-lived plasma cells in pre-autoimmune lupus-prone (NZB×NZW)F1 mice but not in BALB/c mice. European journal of immunology. 2011 Academic Article GET IT
Times cited: 56
Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity. 2011 Academic Article GET IT
Times cited: 929
A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial). Annals of the rheumatic diseases. 2010 Academic Article GET IT
Times cited: 423
Clinical, Molecular, and Genetic Characteristics of PAPA Syndrome: A Review. Current genomics. 2010 Academic Article GET IT
Times cited: 129
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature. 2010 Academic Article GET IT
Times cited: 1362
The interferon-alpha signature of systemic lupus erythematosus. Lupus. 2010 Review GET IT
Times cited: 177
Assessing the human immune system through blood transcriptomics. BMC biology. 2010 Review GET IT
Times cited: 194
TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus. Nature. 2010 Academic Article GET IT
Times cited: 285
Harnessing human dendritic cell subsets for medicine. Immunological reviews. 2010 Review GET IT
Times cited: 145
Pathophysiology of Waldenström's macroglobulinemia. Haematologica. 2010 Editorial Article GET IT
Times cited: 52
Systemic sclerosis and lupus: points in an interferon-mediated continuum. Arthritis and rheumatism. 2010 Academic Article GET IT
Times cited: 151
A genomic approach to human autoimmune diseases. Annual review of immunology. 2010 Review GET IT
Times cited: 124
Classification, presentation, and initial treatment of Wegener's granulomatosis in childhood. Arthritis and rheumatism. 2009 Academic Article GET IT
Times cited: 146
Enhanced monocyte response and decreased central memory T cells in children with invasive Staphylococcus aureus infections. PloS one. 2009 Academic Article GET IT
Times cited: 66
A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus. Immunity. 2008 Academic Article GET IT
Times cited: 504
Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 183
How the study of children with rheumatic diseases identified interferon-alpha and interleukin-1 as novel therapeutic targets. Immunological reviews. 2008 Review GET IT
Times cited: 62
The innate immune system in SLE: type I interferons and dendritic cells. Lupus. 2008 Review GET IT
Times cited: 246
Dendritic cells and cytokines in human inflammatory and autoimmune diseases. Cytokine & growth factor reviews. 2008 Review GET IT
Times cited: 385
Virginia Pascual, MD: a conversation with the editor. Proceedings (Baylor University. Medical Center). 2008 Academic Article GET IT
Microarray-based identification of novel biomarkers in IL-1-mediated diseases. Current opinion in immunology. 2007 Review GET IT
Times cited: 30
Dendritic cell subsets in health and disease. Immunological reviews. 2007 Review GET IT
Times cited: 362
Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 184
Gene expression in peripheral blood mononuclear cells from children with diabetes. The Journal of clinical endocrinology and metabolism. 2007 Academic Article GET IT
Times cited: 173
Systemic lupus erythematosus: all roads lead to type I interferons. Current opinion in immunology. 2006 Review GET IT
Times cited: 250
Persistent expression of autoantibodies in SLE patients in remission. The Journal of experimental medicine. 2006 Academic Article GET IT
Times cited: 112
Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity. 2006 Review GET IT
Times cited: 750
Characterization of monoclonal anti-beta2-glycoprotein-I and anti-prothrombin antibody fragments generated by phage display from a patient with primary antiphospholipid syndrome. Journal of autoimmunity. 2005 Academic Article GET IT
Times cited: 15
Analysis of significance patterns identifies ubiquitous and disease-specific gene-expression signatures in patient peripheral blood leukocytes. Annals of the New York Academy of Sciences. 2005 Academic Article GET IT
Times cited: 41
Autoimmune mechanisms in children with systemic lupus erythematosus. Current rheumatology reports. 2005 Review GET IT
Times cited: 4
[Systemic lupus erythematosus in children]. Anales de pediatria (Barcelona, Spain : 2003). 2005 Review GET IT
Times cited: 17
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. The Journal of experimental medicine. 2005 Academic Article GET IT
Times cited: 763
Autoantibody activity in Waldenstrom's macroglobulinemia. Clinical lymphoma. 2005 Review GET IT
Times cited: 49
Defective B cell tolerance checkpoints in systemic lupus erythematosus. The Journal of experimental medicine. 2005 Academic Article GET IT
Times cited: 540
Cross-regulation of TNF and IFN-alpha in autoimmune diseases. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 454
Dendritic cells control B cell growth and differentiation. Current directions in autoimmunity. 2005 Review GET IT
Times cited: 118
Dramatic improvement of pyoderma gangrenosum with infliximab in a patient with PAPA syndrome. 2005 GET IT
Times cited: 107
Immunotherapy via dendritic cells. Advances in experimental medicine and biology. 2005 Review GET IT
Times cited: 48
Update on pediatric systemic lupus erythematosus. Current opinion in rheumatology. 2004 Review GET IT
Times cited: 77
Autoimmunity through cytokine-induced dendritic cell activation. Immunity. 2004 Review GET IT
Times cited: 277
Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells. The Journal of clinical investigation. 2004 Academic Article GET IT
Times cited: 78
The central role of dendritic cells and interferon-alpha in SLE. Current opinion in rheumatology. 2003 Review GET IT
Times cited: 152
Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity. 2003 Academic Article GET IT
Times cited: 874
Dendritic cells: controllers of the immune system and a new promise for immunotherapy. Annals of the New York Academy of Sciences. 2003 Review GET IT
Times cited: 180
Human germinal center B cells differ from naive and memory B cells by their aggregated MHC class II-rich compartments lacking HLA-DO. International immunology. 2003 Academic Article GET IT
Times cited: 25
Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. The Journal of experimental medicine. 2003 Academic Article GET IT
Times cited: 1613
Dendritic cells: controllers of the immune system and a new promise for immunotherapy. Novartis Foundation symposium. 2003 Review GET IT
Times cited: 39
Blood dendritic cells and DC-poietins in systemic lupus erythematosus. Human immunology. 2002 Academic Article GET IT
Times cited: 94
The interplay of dendritic cell subsets in systemic lupus erythematosus. Immunology and cell biology. 2002 Review GET IT
Times cited: 69
Faces of eosinophilic fasciitis in childhood. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 2002 Academic Article GET IT
Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus. Science (New York, N.Y.). 2001 Academic Article GET IT
Times cited: 1119
Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus. Journal of immunology (Baltimore, Md. : 1950). 2001 Academic Article GET IT
Times cited: 225
Identification of centerin: a novel human germinal center B cell-restricted serpin. European journal of immunology. 2000 Academic Article GET IT
Times cited: 30
Localization of a gene for familial recurrent arthritis. Arthritis and rheumatism. 2000 Academic Article GET IT
Times cited: 62
Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes. The Journal of experimental medicine. 2000 Academic Article GET IT
Times cited: 138
OPG/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40. Journal of immunology (Baltimore, Md. : 1950). 1998 Academic Article GET IT
Times cited: 252
Functional activation of lymphocyte CD44 in peripheral blood is a marker of autoimmune disease activity. The Journal of clinical investigation. 1998 Academic Article GET IT
Times cited: 97
Amino acid insertions and deletions contribute to diversify the human Ig repertoire. Immunological reviews. 1998 Review GET IT
Times cited: 36
Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes. The Journal of experimental medicine. 1998 Academic Article GET IT
Times cited: 215
Normal human B cell sub-populations and their malignant counterparts. Bailliere's clinical haematology. 1997 Review GET IT
Times cited: 14
RDA of lymphocyte subsets. Journal of immunological methods. 1997 Review GET IT
Times cited: 11
Identification and cloning of genes expressed by human tonsillar B lymphocyte subsets. Annals of the New York Academy of Sciences. 1997 Academic Article GET IT
Times cited: 18
Biased VH4 gene segment repertoire in the human tonsil. Chemical immunology. 1997 Academic Article GET IT
Times cited: 14
Staphylococcal protein A binding to VH3 encoded immunoglobulins. International reviews of immunology. 1997 Review GET IT
Times cited: 20
Tolerance to factor VIII inhibitors in hemophilia A patients: a French twist. The Journal of clinical investigation. 1996 Editorial Article GET IT
Times cited: 1
The human antibody repertoire: heavy and light chain variable region gene usage in six alloantibodies specific for human HLA class I and class II alloantigens. Molecular immunology. 1995 Academic Article GET IT
Times cited: 10
Characterization and genomic mapping of a novel leader peptide associated with the human VH4-21 (VH4-34) gene segment. Annals of the New York Academy of Sciences. 1995 Academic Article GET IT
Times cited: 1
Immunoglobulin heavy chain variable region gene usage in human autoimmune diseases. Advances in experimental medicine and biology. 1995 Review GET IT
Times cited: 6
Staphylococcal protein A induces biased production of Ig by VH3-expressing B lymphocytes. Journal of immunology (Baltimore, Md. : 1950). 1994 Academic Article GET IT
Times cited: 80
Analysis of somatic mutation in five B cell subsets of human tonsil. The Journal of experimental medicine. 1994 Academic Article GET IT
Times cited: 588
Nucleotide sequence analysis of natural and combinatorial anti-PDC-E2 antibodies in patients with primary biliary cirrhosis. Recapitulating immune selection with molecular biology. Journal of immunology (Baltimore, Md. : 1950). 1994 Academic Article GET IT
Times cited: 34
Analysis of Ig H chain gene segment utilization in human fetal liver. Revisiting the "proximal utilization hypothesis". Journal of immunology (Baltimore, Md. : 1950). 1993 Academic Article GET IT
Times cited: 64
Complementarity-determining region 2 is implicated in the binding of staphylococcal protein A to human immunoglobulin VHIII variable regions. European journal of immunology. 1993 Academic Article GET IT
Times cited: 50
Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment. The Journal of experimental medicine. 1993 Academic Article GET IT
Times cited: 79
Analysis of human antitopoisomerase-I idiotypes. 1993 GET IT
Times cited: 15
Nucleotide sequence of a human autoantibody to the alternative pathway C3/C5 convertase (C3NeF). Hybridoma. 1993 Academic Article GET IT
Times cited: 6
Synovial IgG rheumatoid factors show evidence of an antigen-driven immune response and a shift in the V gene repertoire compared to IgM rheumatoid factors. European journal of immunology. 1993 Academic Article GET IT
Times cited: 47
Nitric oxide mediates immune dysfunction in the spontaneously hypertensive rat. Hypertension (Dallas, Tex. : 1979). 1993 Academic Article GET IT
Times cited: 35
Human anti-acetylcholine receptor antibodies use variable gene segments analogous to those used in autoantibodies of various specificities. Molecular immunology. 1992 Academic Article GET IT
Times cited: 34
VH restriction among human cold agglutinins. The VH4-21 gene segment is required to encode anti-I and anti-i specificities. Journal of immunology (Baltimore, Md. : 1950). 1992 Academic Article GET IT
Times cited: 197
Human monoclonal striational autoantibodies isolated from thymic B lymphocytes of patients with myasthenia gravis use VH and VL gene segments associated with the autoimmune repertoire. European journal of immunology. 1992 Academic Article GET IT
Times cited: 21
Nucleotide sequence analysis of rheumatoid factors and polyreactive antibodies derived from patients with rheumatoid arthritis reveals diverse use of VH and VL gene segments and extensive variability in CDR-3. Scandinavian journal of immunology. 1992 Academic Article GET IT
Times cited: 74
Rheumatoid factor V genes from patients with rheumatoid arthritis are diverse and show evidence of an antigen-driven response. Immunological reviews. 1992 Review GET IT
Times cited: 43
Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissue. Journal of immunology (Baltimore, Md. : 1950). 1992 Academic Article GET IT
Times cited: 117
Anti-CD3-stimulated T cells induce the production of multiple Ig H chain isotypes by individual human peripheral B lymphocytes. Journal of immunology (Baltimore, Md. : 1950). 1992 Academic Article GET IT
Times cited: 12
IgM rheumatoid factors in patients with rheumatoid arthritis derive from a diverse array of germline immunoglobulin genes and display little evidence of somatic variation. The Journal of rheumatology. Supplement. 1992 Academic Article GET IT
Times cited: 18
Spontaneously hypertensive rat: lymphoid depression is age dependent and mediated via a mononuclear cell subpopulation. The American journal of physiology. 1992 Academic Article GET IT
Times cited: 27
The human VH repertoire: a restricted set of VH genes may be the target of immune regulation. International reviews of immunology. 1992 Review GET IT
Times cited: 14
VH4-21, a human VH gene segment overrepresented in the autoimmune repertoire. Arthritis and rheumatism. 1992 Review GET IT
Times cited: 127
B-cell superantigens?. Current biology : CB. 1991 Academic Article GET IT
Human monoclonal antibodies against blood group antigens preferentially express a VH4-21 variable region gene-associated epitope. Scandinavian journal of immunology. 1991 Academic Article GET IT
Times cited: 92
Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype. Journal of immunology (Baltimore, Md. : 1950). 1991 Academic Article GET IT
Times cited: 170
Human immunoglobulin heavy-chain variable region genes: organization, polymorphism, and expression. Advances in immunology. 1991 Review GET IT
Times cited: 201
Some cautionary notes on interpreting immunoglobulin variable gene segment restriction in autoimmune disease. Immunology series. 1991 Review GET IT
Times cited: 2
The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidence that some autoantibodies are unmutated copies of germ line genes. The Journal of clinical investigation. 1990 Academic Article GET IT
Times cited: 158
Nucleotide sequence of a human monoclonal anti-idiotypic antibody specific for a rabies virus-neutralizing monoclonal idiotypic antibody reveals extensive somatic variability suggestive of an antigen-driven immune response. Journal of immunology (Baltimore, Md. : 1950). 1990 Academic Article GET IT
Times cited: 32
Heavy chain variable region gene utilization in human antibodies. International reviews of immunology. 1990 Review GET IT
Times cited: 13
Probing of the rheumatoid factor (RF) V gene repertoire in rheumatoid arthritis (RA) by hybridoma clones. Clinical and experimental rheumatology. 1990 Academic Article GET IT
Times cited: 15

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Research

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Funding awarded

Center for Lupus Research awarded by National Inst of Arthritis & Musculoskeletal & Skin Diseases Principal Investigator 2022 - 2027
Molecular Fingerprinting of Lupus in Children awarded by Lupus Research Alliance Principal Investigator 2022 - 2025
Immune Cells and Secretory Pathways Leading to Human Systemic Autoimmunity awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2021 - 2024
Immune Cells and Secretory Pathways Leading to Human Systemic Autoimmunity awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2019 - 2024
Addgene 701923 awarded by Addgene, Inc. Principal Investigator 2022 - 2023
Immune Cells and Secretory Pathways Leading to Human Systemic Autoimmunity awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2020 - 2023
BioPharma Alliance Agreement awarded by Sanofi US Principal Investigator 2019 - 2023

Hypoxic incubator for physiological cell culture research awarded by National Institutes of Health, Office of the Director Key Personnel 2022 - 2023

A deep longitudinal analysis of next generation influenza vaccines in older adults. awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2022 - 2026
High-resolution single cell profiling of vaccine responsiveness in the elderly awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2019 - 2024

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Background

education and training

M.D., Universidad Complutense Faculty of Medicine (Spain) 1981
B.A., Centro de Estudios Universitarios-San Pablo (Spain) 1975

Contact

full name

Virginia Pascual

primary email

vip2021@med.cornell.edu

VIVO Weill Cornell Medical College

Virginia Pascual Director, Drukier Institute

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email