Extracellular vesicle- and particle-mediated communication shapes innate and adaptive immune responses. Review uri icon

Overview

abstract

  • Intercellular communication among immune cells is vital for the coordination of proper immune responses. Extracellular vesicles and particles (EVPs) act as messengers in intercellular communication, with important consequences for target cell and organ physiology in both health and disease. Under normal physiological conditions, immune cell-derived EVPs participate in immune responses by regulating innate and adaptive immune responses. EVPs play a major role in antigen presentation and immune activation. On the other hand, immune cell-derived EVPs exert immunosuppressive and regulatory effects. Consequently, EVPs may contribute to pathological conditions, such as autoimmune and inflammatory diseases, graft rejection, and cancer progression and metastasis. Here, we provide an overview of the role of EVPs in immune homeostasis and pathophysiology, with a particular focus on their contribution to innate and adaptive immunity and their potential use for immunotherapies.

publication date

  • June 28, 2021

Research

keywords

  • Adaptive Immunity
  • Cell Communication
  • Cell-Derived Microparticles
  • Extracellular Vesicles
  • Immunity, Innate

Identity

PubMed Central ID

  • PMC8241538

Scopus Document Identifier

  • 85109261252

Digital Object Identifier (DOI)

  • 10.1038/nm0598-594

PubMed ID

  • 34180950

Additional Document Info

volume

  • 218

issue

  • 8