Chen, Wenhao

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selected publications

PIRs mediate innate myeloid cell memory to nonself MHC molecules. Science (New York, N.Y.). 2020 Academic Article GET IT
Times cited: 68
T cell exhaustion is associated with antigen abundance and promotes transplant acceptance. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2020 Academic Article GET IT
Times cited: 15
Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2020 Academic Article GET IT
Times cited: 9
T follicular helper and memory cell responses and the mTOR pathway in murine heart transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2019 Academic Article GET IT
Times cited: 7
Ablation of interferon regulatory factor 4 in T cells induces "memory" of transplant tolerance that is irreversible by immune checkpoint blockade. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2018 Academic Article GET IT
Times cited: 13
OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms. Cell reports. 2018 Academic Article GET IT
Times cited: 66
Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts. Transplant immunology. 2018 Academic Article GET IT
Times cited: 14
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4⁺ T Cell Dysfunction. Immunity. 2017 Academic Article GET IT
Times cited: 62
Macrophage subpopulations and their impact on chronic allograft rejection versus graft acceptance in a mouse heart transplant model. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2017 Academic Article GET IT
Times cited: 43
Anti-TCRβ mAb in Combination With Neurogenin3 Gene Therapy Reverses Established Overt Type 1 Diabetes in Female NOD Mice. Endocrinology. 2017 Academic Article GET IT
Times cited: 4
Dissonant response of M0/M2 and M1 bone-marrow-derived macrophages to RhoA pathway interference. Cell and tissue research. 2016 Academic Article GET IT
Times cited: 22
Macrophage/monocyte-specific deletion of Ras homolog gene family member A (RhoA) downregulates fractalkine receptor and inhibits chronic rejection of mouse cardiac allografts. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2016 Academic Article GET IT
Times cited: 30
The Evolving Roles of Memory Immune Cells in Transplantation. Transplantation. 2015 Review GET IT
Times cited: 14
Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015 Academic Article GET IT
Times cited: 12
PD-1-dependent restoration of self-tolerance in the NOD mouse model of diabetes after transient anti-TCRβ mAb therapy. Diabetologia. 2015 Academic Article GET IT
Times cited: 3
PD-L1-driven tolerance protects neurogenin3-induced islet neogenesis to reverse established type 1 diabetes in NOD mice. Diabetes. 2014 Academic Article GET IT
Times cited: 18
TCR stimulation without co-stimulatory signals induces expression of "tolerogenic" genes in memory CD4 T cells but does not compromise cell proliferation. Molecular immunology. 2014 Academic Article GET IT
Times cited: 2
Molecular insights into the development of T cell-based immunotherapy for prostate cancer. Expert review of clinical immunology. 2014 Review GET IT
Times cited: 7
Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice. Transplantation. 2014 Academic Article GET IT
Times cited: 4
MAFbx/Atrogin-1 is required for atrophic remodeling of the unloaded heart. Journal of molecular and cellular cardiology. 2014 Academic Article GET IT
Times cited: 21
Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions. PloS one. 2014 Academic Article GET IT
Times cited: 12
Transient combination therapy targeting the immune synapse abrogates T cell responses and prolongs allograft survival in mice. PloS one. 2013 Academic Article GET IT
Times cited: 4
GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency. The Journal of clinical investigation. 2013 Academic Article GET IT
Times cited: 60
A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells. Journal of immunology (Baltimore, Md. : 1950). 2013 Academic Article GET IT
Times cited: 15
Digoxin attenuates acute cardiac allograft rejection by antagonizing RORγt activity. Transplantation. 2013 Academic Article GET IT
Times cited: 23
Mechanistic basis of immunotherapies for type 1 diabetes mellitus. Translational research : the journal of laboratory and clinical medicine. 2013 Review GET IT
Times cited: 22
Anti-TCRβ mAb induces long-term allograft survival by reducing antigen-reactive T cells and sparing regulatory T cells. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2012 Academic Article GET IT
Times cited: 15
CCR5 blockade in combination with cyclosporine increased cardiac graft survival and generated alternatively activated macrophages in primates. Journal of immunology (Baltimore, Md. : 1950). 2011 Academic Article GET IT
Times cited: 24
Treatment with interleukin-12/23p40 antibody attenuates acute cardiac allograft rejection. Transplantation. 2011 Academic Article GET IT
Times cited: 24
IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4+CD25+ regulatory T cell which jointly restrain CD4+CD25- cell activation. Immunology letters. 2010 Academic Article GET IT
Times cited: 21
"Default" generation of neonatal regulatory T cells. Journal of immunology (Baltimore, Md. : 1950). 2010 Academic Article GET IT
Times cited: 105
IL-7, but not thymic stromal lymphopoietin (TSLP), during priming enhances the generation of memory CD4+ T cells. Immunology letters. 2010 Academic Article GET IT
Times cited: 5
Expanding and converting regulatory T cells: a horizon for immunotherapy. Archivum immunologiae et therapiae experimentalis. 2009 Review GET IT
Times cited: 28
Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 252
STAT3: an important regulator of multiple cytokine functions. Transplantation. 2008 Review GET IT
Times cited: 59
Functional quartet by CD4+ T cells: a concerto of multiple cytokines. Expert review of clinical immunology. 2008 Editorial Article GET IT
Times cited: 2
Antigen transmission by replicating antigen-bearing dendritic cells. Journal of immunology (Baltimore, Md. : 1950). 2007 Academic Article GET IT
Times cited: 18
Both infiltrating regulatory T cells and insufficient antigen presentation are involved in long-term cardiac xenograft survival. Journal of immunology (Baltimore, Md. : 1950). 2007 Academic Article GET IT
Times cited: 16
Peptide-activated double-negative T cells can prevent autoimmune type-1 diabetes development. European journal of immunology. 2007 Academic Article GET IT
Times cited: 51
Lentivirally transduced recipient-derived dendritic cells serve to ex vivo expand functional FcRgamma-sufficient double-negative regulatory T cells. Molecular therapy : the journal of the American Society of Gene Therapy. 2007 Academic Article GET IT
Times cited: 3
Double-negative T regulatory cells can develop outside the thymus and do not mature from CD8+ T cell precursors. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 48
FcR gamma presence in TCR complex of double-negative T cells is critical for their regulatory function. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 18
In situ replication of immediate dendritic cell (DC) precursors contributes to conventional DC homeostasis in lymphoid tissue. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 85
CXCR5/CXCL13 interaction is important for double-negative regulatory T cell homing to cardiac allografts. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 27
Donor lymphocyte infusion induces long-term donor-specific cardiac xenograft survival through activation of recipient double-negative regulatory T cells. Journal of immunology (Baltimore, Md. : 1950). 2005 Academic Article GET IT
Times cited: 54
Targeted deletion of Fgl-2/fibroleukin in the donor modulates immunologic response and acute vascular rejection in cardiac xenografts. Circulation. 2005 Academic Article GET IT
Times cited: 58
Expression profiling of murine double-negative regulatory T cells suggest mechanisms for prolonged cardiac allograft survival. Journal of immunology (Baltimore, Md. : 1950). 2005 Academic Article GET IT
Times cited: 35
Methoxyethyl-modified intercellular adhesion molecule-1 antisense phosphorothiateoligonucleotides inhibit allograft rejection, ischemic-reperfusion injury, and cyclosporine-induced nephrotoxicity. Transplantation. 2005 Academic Article GET IT
Times cited: 10
The role and mechanisms of double negative regulatory T cells in the suppression of immune responses. Cellular & molecular immunology. 2004 Review GET IT
Times cited: 47
Characterization of distinct conventional and plasmacytoid dendritic cell-committed precursors in murine bone marrow. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 92
Infusion of in vitro-generated DN T regulatory cells induces permanent cardiac allograft survival in mice. Transplantation proceedings. 2003 Academic Article GET IT
Times cited: 37
Role of double-negative regulatory T cells in long-term cardiac xenograft survival. Journal of immunology (Baltimore, Md. : 1950). 2003 Academic Article GET IT
Times cited: 64
An oral formulation for intracellular adhesion molecules-1 antisense oligonucleotides. Transplantation proceedings. 2001 Academic Article GET IT
Times cited: 4
Development of an oral formulation for ICAM-1 antisense oligonucleotides. Transplantation proceedings. 2001 Academic Article GET IT
Times cited: 3
Methoxyethyl modification of phosphorothioate ICAM-1 antisense oligonucleotides improves prevention of ischemic/reperfusion injury. Transplantation proceedings. 2001 Academic Article GET IT
Times cited: 6
Phosphorothioate/methoxyethyl-modified ICAM-1 antisense oligonucleotides improves prevention of ischemic/reperfusion injury. Transplantation proceedings. 2001 Academic Article GET IT
Times cited: 12
Inhibition of C-raf expression by antisense oligonucleotides extends heart allograft survival in rats. Transplantation. 2000 Academic Article GET IT
Times cited: 21
Perfusion of kidneys with unformulated "naked" intercellular adhesion molecule-1 antisense oligodeoxynucleotides prevents ischemic/reperfusion injury. Transplantation. 1999 Academic Article GET IT
Times cited: 38
Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nature medicine. 1998 Academic Article GET IT
Times cited: 365
Protection against allograft rejection with intercellular adhesion molecule-1 antisense oligodeoxynucleotides. Transplantation. 1998 Academic Article GET IT
Times cited: 59

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Background

education and training

Ph.D., University of Toronto (Canada) 2006
B.M., Shanghai Second Medical University (China) 1994

Contact

full name

Wenhao Chen

VIVO Weill Cornell Medical College

Wenhao Chen Assistant Professor of Immunology in Surgery

Publications

selected publications

Background

education and training

Contact

full name