de Jong, Ype P.

Publications

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selected publications

An RNA-based system to study hepatitis B virus replication and evaluate antivirals. Science advances. 2023 Academic Article GET IT
Characterization of a Bioengineered AAV3B Capsid Variant with Enhanced Hepatocyte Tropism and Immune Evasion. Human gene therapy. 2023 Academic Article GET IT
Comprehensive comparison of stroke risk score performance: a systematic review and meta-analysis among 6 267 728 patients with atrial fibrillation. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2022 Review GET IT
Ectopic clotting factor VIII expression and misfolding in hepatocytes as a cause for hepatocellular carcinoma. Molecular therapy : the journal of the American Society of Gene Therapy. 2022 Academic Article GET IT
Times cited: 1
Cardiorenal Outcomes Among Patients With Atrial Fibrillation Treated With Oral Anticoagulants. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2022 Academic Article GET IT
Times cited: 1
Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice. Cell reports. 2022 Academic Article GET IT
Times cited: 2
Targeting BCL-XL in fibrolamellar hepatocellular carcinoma. JCI insight. 2022 Academic Article GET IT
Times cited: 3
AAV and hepatitis: Cause or coincidence?. Molecular therapy : the journal of the American Society of Gene Therapy. 2022 Editorial Article GET IT
Times cited: 4
IL-15 blockade and rapamycin rescue multifactorial loss of factor VIII from AAV-transduced hepatocytes in hemophilia A mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2022 Academic Article GET IT
Times cited: 6
The influence of corn trypsin inhibitor on the contribution of coagulation determinants to the Technoclone Thrombin Generation Assay (TGA) and the Calibrated Automated Thrombogram (CAT). PloS one. 2022 Academic Article GET IT
Mouse characteristics that affect establishing xenografts from hepatocellular carcinoma patient biopsies in the United States. Cancer medicine. 2021 Academic Article GET IT
RNR-R2 Upregulation by a Short Non-Coding Viral Transcript. Biomolecules. 2021 Academic Article GET IT
Times cited: 1
Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening. Cancer discovery. 2021 Academic Article GET IT
Times cited: 14
Primary human hepatocyte gene editing: Prometheus' chains are loosening. Molecular therapy : the journal of the American Society of Gene Therapy. 2021 Comment GET IT
Liver gene therapy and hepatocellular carcinoma: A complex web. Molecular therapy : the journal of the American Society of Gene Therapy. 2021 Editorial Article GET IT
Times cited: 11
Single-Cell Sorting of HBsAg-Binding Memory B Cells from Human Peripheral Blood Mononuclear Cells and Antibody Cloning. STAR protocols. 2020 Academic Article GET IT
Times cited: 2
Engineering and In Vitro Selection of a Novel AAV3B Variant with High Hepatocyte Tropism and Reduced Seroreactivity. Molecular therapy. Methods & clinical development. 2020 Academic Article GET IT
Times cited: 15
Microthrombosis associated with GI bleeding in COVID-19. 2020 GET IT
Times cited: 7
A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations. Cell host & microbe. 2020 Academic Article GET IT
Times cited: 37
Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice. Molecular therapy. Methods & clinical development. 2020 Academic Article GET IT
Times cited: 11
Stem cell-derived HCV infection systems illustrate the bright future of human hepatocyte research. Gut. 2020 Comment GET IT
Immune Responses to Viral Gene Therapy Vectors. Molecular therapy : the journal of the American Society of Gene Therapy. 2020 Review GET IT
Times cited: 255
Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 31
Characterization of Novel Splice Variants of Zinc Finger Antiviral Protein (ZAP). Journal of virology. 2019 Academic Article GET IT
Times cited: 48
Inherited IL-18BP deficiency in human fulminant viral hepatitis. 2019 GET IT
Times cited: 57
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids. Cell. 2018 Academic Article GET IT
Times cited: 374
Hepatitis C Virus Neutralizing Antibodies: Is a Vaccine Still Possible?. Cell host & microbe. 2018 Comment GET IT
Times cited: 1
Modeling Unique Patients in Humanized Mice: Toward a Curative Strategy for HIV. Molecular therapy : the journal of the American Society of Gene Therapy. 2018 Editorial Article GET IT
Fatal sudden paralysis of the lower extremities. The Netherlands journal of medicine. 2017 Academic Article GET IT
A robust cell culture system supporting the complete life cycle of hepatitis B virus. Scientific reports. 2017 Academic Article GET IT
Times cited: 47
Analysis of Hepatitis C Virus Particle Heterogeneity in Immunodeficient Human Liver Chimeric fah-/- Mice. Cellular and molecular gastroenterology and hepatology. 2017 Academic Article GET IT
Times cited: 6
In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease. Science translational medicine. 2017 Academic Article GET IT
Times cited: 116
The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity. Immunity. 2017 Academic Article GET IT
Times cited: 68
The Balance between CD8⁺ T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose. Molecular therapy : the journal of the American Society of Gene Therapy. 2017 Academic Article GET IT
Times cited: 38
Dynamics of antigen presentation to transgene product-specific CD4⁺ T cells and of Treg induction upon hepatic AAV gene transfer. Molecular therapy. Methods & clinical development. 2016 Academic Article GET IT
Fibrosis Progression in Patients With Chronic Hepatitis C Virus Infection. The Journal of infectious diseases. 2016 Academic Article GET IT
Times cited: 17
Humanized mice efficiently engrafted with fetal hepatoblasts and syngeneic immune cells develop human monocytes and NK cells. Journal of hepatology. 2016 Academic Article GET IT
Times cited: 62
Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid. Molecular therapy : the journal of the American Society of Gene Therapy. 2016 Academic Article GET IT
Times cited: 79
Animal models for the study of HCV. Current opinion in virology. 2015 Review GET IT
Times cited: 24
Hepatitis C virus infects rhesus macaque hepatocytes and simianized mice. Hepatology (Baltimore, Md.). 2015 Academic Article GET IT
Times cited: 19
Hepatitis C virus RNA functionally sequesters miR-122. Cell. 2015 Academic Article GET IT
Times cited: 256
HCV animal models and liver disease. Journal of hepatology. 2014 Review GET IT
Times cited: 36
Broadly neutralizing antibodies abrogate established hepatitis C virus infection. Science translational medicine. 2014 Academic Article GET IT
Times cited: 181
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 196
Virus associated malignancies: the role of viral hepatitis in hepatocellular carcinoma. Seminars in cancer biology. 2014 Review GET IT
Times cited: 119
Antisense therapy for hepatitis C virus infection. Journal of hepatology. 2013 Comment GET IT
Times cited: 14
Emerging therapeutic targets for hepatitis C virus infection. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2013 Review GET IT
Times cited: 14
Animal models for hepatitis C. Current topics in microbiology and immunology. 2013 Review GET IT
Times cited: 73
Evaluation of combination therapy against hepatitis C virus infection in human liver chimeric mice. Journal of hepatology. 2010 Editorial Article GET IT
Times cited: 5
New horizons for studying human hepatotropic infections. The Journal of clinical investigation. 2010 Comment GET IT
Times cited: 44
Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell host & microbe. 2009 Review GET IT
Times cited: 177
Use of spoligotyping and large sequence polymorphisms to study the population structure of the Mycobacterium tuberculosis complex in a cohort study of consecutive smear-positive tuberculosis cases in The Gambia. Journal of clinical microbiology. 2009 Academic Article GET IT
Times cited: 49
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells. Nature. 2009 Academic Article GET IT
Times cited: 756
In vivo generation of oligoclonal colitic CD4+ T-cell lines expressing a distinct T-cell receptor Vbeta. Gastroenterology. 2005 Academic Article GET IT
Times cited: 4
Colitis is associated with thymic destruction attenuating CD4+25+ regulatory T cells in the periphery. Gastroenterology. 2004 Academic Article GET IT
Times cited: 38
Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation. Immunity. 2004 Academic Article GET IT
Times cited: 130
Blocking inducible co-stimulator in the absence of CD28 impairs Th1 and CD25+ regulatory T cells in murine colitis. International immunology. 2004 Academic Article GET IT
Times cited: 33
Role of the CD5 molecule on TCR gammadelta T cell-mediated immune functions: development of germinal centers and chronic intestinal inflammation. International immunology. 2003 Academic Article GET IT
Times cited: 21
Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice. Gastroenterology. 2002 Academic Article GET IT
Development of chronic colitis is dependent on the cytokine MIF. Nature immunology. 2001 Academic Article GET IT
Times cited: 274
Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg(epsilon26) mice. Gastroenterology. 2001 Academic Article GET IT
Times cited: 122
Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administration. Gastroenterology. 2000 Academic Article GET IT
Times cited: 84
Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice. Gastroenterology. 2000 Academic Article GET IT
Times cited: 181
Pathways of T cell pathology in models of chronic intestinal inflammation. International reviews of immunology. 2000 Review GET IT
Times cited: 9
High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 1999 Academic Article GET IT
Times cited: 38
Consequences of Fas-ligand and perforin expression by colon T cells in a mouse model of inflammatory bowel disease. Gastroenterology. 1998 Academic Article GET IT
Times cited: 22
Development of colonic adenocarcinomas in a mouse model of ulcerative colitis. Inflammatory bowel diseases. 1998 Academic Article GET IT
Times cited: 30
T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells. The Journal of experimental medicine. 1998 Academic Article GET IT
Times cited: 253
T cells in mouse models of gut inflammation. Chemical immunology. 1998 Review GET IT
Times cited: 7
Interleukin 8 released after acute myocardial infarction is mainly bound to erythrocytes. Heart (British Cardiac Society). 1997 Academic Article GET IT
Times cited: 37

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Research

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Co-investigator Network

Funding awarded

Modeling alcohol toxicity in human hepatocytes awarded by National Institute on Alcohol Abuse & Alcoholism Principal Investigator 2019 - 2024

Core B: Human Hepatocyte and Discovery awarded by National Heart, Lung, & Blood Institute Principal Investigator Subaward 2022 - 2027
Project 3: Mechanisms of Innate and Adaptive Immune Responses to AAV-FVIII Gene Transfer awarded by National Heart, Lung, & Blood Institute Principal Investigator Subaward 2022 - 2027
Launching HBV with RNA to assess antiviral resistance and explore fundamental aspects of virus-host biology awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2022 - 2025
Enhancing Immune Regulation In Gene Therapy For Hemophilia awarded by National Heart, Lung, & Blood Institute Principal Investigator Subaward 2021 - 2025
In search of an HBV cure: novel model systems and targets awarded by Bill & Melinda Gates Foundation Principal Investigator Subaward 2019 - 2024

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Background

education and training

M.D., University of Amsterdam Faculty of Medicine (Netherlands) 2003
Ph.D., University of Amsterdam (Netherlands) 2002

Contact

full name

Ype P. de Jong

primary email

ydj2001@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Ype P. de Jong Assistant Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage