Nature medicine

publication venue for

Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child. 2021
Immunogenic neoantigens derived from gene fusions stimulate T cell responses. 2019
Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial.. 29. 2023
Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma.. 29. 2023
Germline variants associated with toxicity to immune checkpoint blockade.. 28. 2022
Data-driven identification of post-acute SARS-CoV-2 infection subphenotypes.. 29. 2022
Rare and common genetic determinants of metabolic individuality and their effects on human health.. 28. 2022
Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial.. 28. 2022
Screening for idiopathic pulmonary fibrosis using comorbidity signatures in electronic health records.. 28. 2022
Genomic and transcriptomic determinants of response to neoadjuvant therapy in rectal cancer.. 28. 2022
Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer.. 28. 2022
An early warning system for emerging SARS-CoV-2 variants.. 28. 2022
An ethical plan for including forcibly displaced persons in omics and digital technology research.. 28. 2022
Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.. 28. 2022
Reimagining patient-centric cancer clinical trials: a multi-stakeholder international coalition.. 28. 2022
High burden of clonal hematopoiesis in first responders exposed to the World Trade Center disaster.. 28. 2022
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity.. 28. 2022
Avelumab maintenance in advanced urothelial carcinoma: biomarker analysis of the phase 3 JAVELIN Bladder 100 trial.. 27. 2021
BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the SARS-CoV-2 Delta variant in Qatar.. 27. 2021
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial.. 27. 2021
Microglial activation and tau propagate jointly across Braak stages.. 27. 2021
The Tuberculosis Drug Accelerator at year 10: what have we learned?. 27. 2021
mRNA-1273 COVID-19 vaccine effectiveness against the B.1.1.7 and B.1.351 variants and severe COVID-19 disease in Qatar.. 27. 2021
CD8⁺ T cells contribute to survival in patients with COVID-19 and hematologic cancer.. 27. 2021
Equitable allocation of COVID-19 vaccines in the United States.. 27. 2021
First-generation physician-scientists are under-represented and need better support.. 27. 2021
A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial.. 27. 2020
The immune roadmap for understanding multi-system inflammatory syndrome in children: opportunities and challenges.. 26. 2020
Precision medicine treatment in acute myeloid leukemia using prospective genomic profiling: feasibility and preliminary efficacy of the Beat AML Master Trial.. 26. 2020
Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection.. 26. 2020
Building an international consortium for tracking coronavirus health status.. 26. 2020
Publisher Correction: Building an international consortium for tracking coronavirus health status.. 26. 2020
Myocardial infarction accelerates breast cancer via innate immune reprogramming.. 26. 2020
COVID-19 in Africa: the spread and response.. 26. 2020
Determinants of COVID-19 disease severity in patients with cancer.. 26. 2020
Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes.. 26. 2020
Human-computer collaboration for skin cancer recognition.. 26. 2020
Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment.. 26. 2020
Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring.. 26. 2020
BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial.. 26. 2020
Artificial intelligence-enabled rapid diagnosis of patients with COVID-19.. 26. 2020
T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers.. 26. 2020
Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus.. 26. 2020
Regenerative lineages and immune-mediated pruning in lung cancer metastasis.. 26. 2020
Antitumor activity of crizotinib in lung cancers harboring a MET exon 14 alteration.. 26. 2020
High-resolution mycobiota analysis reveals dynamic intestinal translocation preceding invasive candidiasis.. 26. 2020
Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms.. 25. 2019
High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants.. 25. 2019
Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans.. 25. 2019
Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy.. 25. 2019
A rectal cancer organoid platform to study individual responses to chemoradiation.. 25. 2019
Deep learning-based classification of mesothelioma improves prediction of patient outcome.. 25. 2019
Resistance to TRK inhibition mediated by convergent MAPK pathway activation.. 25. 2019
Clinical-grade computational pathology using weakly supervised deep learning on whole slide images.. 25. 2019
Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism.. 25. 2019
Rational design of anti-GITR-based combination immunotherapy.. 25. 2019
A new approach for inflammatory bowel disease therapy.. 25. 2019
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma.. 25. 2019
RAF inhibitor PLX8394 selectively disrupts BRAF dimers and RAS-independent BRAF-mutant-driven signaling.. 25. 2018
The molecular landscape of glioma in patients with Neurofibromatosis 1.. 25. 2018
Wiskott-Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma.. 25. 2018
A CD4⁺ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate.. 25. 2018
Radiotherapy induces responses of lung cancer to CTLA-4 blockade.. 24. 2018
Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals.. 24. 2018
Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia.. 24. 2018
Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia.. 24. 2018
Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib.. 24. 2018
Somatic mutations precede acute myeloid leukemia years before diagnosis.. 24. 2018
DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.. 24. 2018
Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle.. 24. 2018
Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma.. 24. 2018
CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade.. 24. 2018
Targeting skeletal endothelium to ameliorate bone loss.. 24. 2018
Clonal CD4⁺ T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation.. 24. 2018
Corrigendum: Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury.. 24. 2018
Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury.. 24. 2018
The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.. 24. 2018
The N⁶-methyladenosine (m⁶A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.. 23. 2017
Sex-specific transcriptional signatures in human depression.. 23. 2017
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.. 23. 2017
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.. 23. 2017
Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.. 23. 2017
An approach to suppress the evolution of resistance in BRAF^V600E-mutant cancer.. 23. 2017
Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.. 23. 2017
Biology and evolution of poorly differentiated neuroendocrine tumors.. 23. 2017
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.. 23. 2017
Erratum: Resting-state connectivity biomarkers define neurophysiological subtypes of depression.. 23. 2017
Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples.. 23. 2017
Antibody 10-1074 suppresses viremia in HIV-1-infected individuals.. 23. 2017
Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity.. 23. 2017
Corrigendum: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.. 22. 2016
Resting-state connectivity biomarkers define neurophysiological subtypes of depression.. 23. 2016
DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling.. 22. 2016
Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination.. 22. 2016
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses.. 22. 2016
NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages.. 22. 2016
Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.. 22. 2016
Erratum: Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.. 22. 2016
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.. 22. 2016
Facilitating a culture of responsible and effective sharing of cancer genome data.. 22. 2016
Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.. 22. 2016
Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells.. 22. 2016
PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.. 22. 2016
Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells.. 22. 2016
Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma.. 22. 2016
Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer.. 22. 2016
Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis.. 22. 2016
Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.. 22. 2016
Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.. 21. 2015
Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis.. 21. 2015
PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.. 21. 2015
Loss of BAP1 function leads to EZH2-dependent transformation.. 21. 2015
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.. 21. 2015
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.. 21. 2015
Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure.. 21. 2015
Toward understanding and exploiting tumor heterogeneity.. 21. 2015
Common clonal origin of central and resident memory T cells following skin immunization.. 21. 2015
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.. 21. 2015
Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.. 20. 2014
Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.. 20. 2014
A new tumor suppressor role for the Notch pathway in bladder cancer.. 20. 2014
Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer.. 20. 2014
Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.. 20. 2014
Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine.. 20. 2014
Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers.. 20. 2014
Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia.. 20. 2014
Tumor heterogeneity confounds and illuminates: assessing the implications.. 20. 2014
Harnessing microbiota to kill a pathogen: Fixing the microbiota to treat Clostridium difficile infections.. 20. 2014
Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.. 20. 2013
Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c.. 19. 2013
CSF-1R inhibition alters macrophage polarization and blocks glioma progression.. 19. 2013
Quantitative imaging of disease signatures through radioactive decay signal conversion.. 19. 2013
Roadblocks to translational advances on metastasis research.. 19. 2013
Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.. 19. 2013
BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint.. 19. 2013
ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss.. 19. 2013
Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection.. 19. 2013
Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis.. 19. 2013
Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis.. 19. 2013
Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia.. 19. 2013
Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation.. 19. 2013
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice.. 19. 2013
Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes.. 19. 2012
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.. 19. 2012
Hiding under the skin: A welcome surprise in psoriasis.. 18. 2012
Multifunctional in vivo vascular imaging using near-infrared II fluorescence.. 18. 2012
PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas.. 18. 2012
Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression.. 18. 2012
Annotating MYC status with 89Zr-transferrin imaging.. 18. 2012
Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia.. 18. 2012
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.. 18. 2012
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue.. 18. 2012
A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle.. 18. 2012
Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation.. 18. 2012
High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions.. 18. 2012
Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases.. 18. 2012
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia.. 18. 2012
Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease.. 17. 2011
Identification of a central role for complement in osteoarthritis.. 17. 2011
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido.. 17. 2011
Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma.. 17. 2011
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs.. 17. 2011
The Ngal reporter mouse detects the response of the kidney to injury in real time.. 17. 2011
miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma.. 16. 2010
Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma.. 16. 2010
Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice.. 16. 2010
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.. 16. 2010
A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas.. 15. 2009
Bleeding in the brain: Killer waves of depolarization in subarachnoid bleed.. 15. 2009
Shifting paradigms: the seeds of oncogene addiction.. 15. 2009
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake.. 15. 2009
Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis.. 15. 2009
NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury.. 15. 2009
Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells.. 15. 2009
Sensitive in vivo imaging of T cells using a membrane-bound Gaussia princeps luciferase.. 15. 2009
Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway.. 15. 2009
Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus.. 15. 2008
Building a prostate.. 14. 2008
Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections.. 14. 2008
A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis.. 14. 2008
Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study.. 14. 2008
Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans.. 14. 2008
The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination.. 14. 2008
Therapeutic cloning in individual parkinsonian mice.. 14. 2008
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice.. 13. 2007
T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection.. 13. 2007
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.. 13. 2007
A spatially and temporally restricted mouse model of soft tissue sarcoma.. 13. 2007
Derivation of engraftable skeletal myoblasts from human embryonic stem cells.. 13. 2007
Aligning pharmaceutical innovation with medical need.. 13. 2007
Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes.. 12. 2006
Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation.. 12. 2006
Is cancer a disease of self-seeding?. 12. 2006
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma.. 12. 2006
Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing.. 12. 2006
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes.. 12. 2006
Viral nanoparticles as tools for intravital vascular imaging.. 12. 2006
Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity.. 12. 2006
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer.. 12. 2005
Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor.. 11. 2005
Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases.. 11. 2005
Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target.. 11. 2005
ATM regulates target switching to escalating doses of radiation in the intestines.. 11. 2005
Regulation of NKT cell development by SAP, the protein defective in XLP.. 11. 2005
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer.. 11. 2004
Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.. 10. 2004
The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers.. 10. 2004
Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation.. 10. 2004
Urgently needed: a filter for the HIV-1 vaccine pipeline.. 10. 2004
Trans-splicing repair of CD40 ligand deficiency results in naturally regulated correction of a mouse model of hyper-IgM X-linked immunodeficiency.. 10. 2004
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.. 10. 2004
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis.. 10. 2003
Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain.. 10. 2003
Molecular determinants of resistance to antiandrogen therapy.. 10. 2003
Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer.. 9. 2003
Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo.. 9. 2003
Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain.. 9. 2003
Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15.. 9. 2003
Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120.. 9. 2003
Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts.. 9. 2003
Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury.. 9. 2003
T cells require TRAIL for optimal graft-versus-tumor activity.. 8. 2002
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment.. 8. 2002
AIDS vaccine models: challenging challenge viruses.. 8. 2002
Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth.. 7. 2001
In vivo optical mapping of epileptic foci and surround inhibition in ferret cerebral cortex.. 7. 2001
A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation.. 7. 2001
Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis.. 7. 2001
Positron emission tomography imaging for herpes virus infection: Implications for oncolytic viral treatments of cancer.. 7. 2001
Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis.. 7. 2001
IL-15 and IL-2: a matter of life and death for T cells in vivo.. 7. 2001
The National Institutes of Health and clinical research: a progress report.. 6. 2000
Dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can initiate antigen-specific humoral immunity independent of CD4+ T cells.. 6. 2000
Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy.. 6. 2000
a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer.. 6. 2000
Successful DNA immunization against measles: neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles.. 6. 2000
Reply to "Human neural progenitor cells: better blue than green?".. 6. 2000
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway.. 6. 2000
In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus.. 6. 2000
Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance.. 5. 1999
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.. 5. 1999
A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase.. 5. 1999
Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration.. 4. 1998
Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy.. 4. 1998
Peroral gene therapy of lactose intolerance using an adeno-associated virus vector.. 4. 1998
Differentiation and reversal of malignant changes in colon cancer through PPARgamma.. 4. 1998
Expression of heme oxygenase-1 can determine cardiac xenograft survival.. 4. 1998
Why do we not have an HIV vaccine and how can we make one?. 4. 1998
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.. 4. 1998
A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation.. 4. 1998
Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice.. 4. 1998
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.. 4. 1998
Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression.. 4. 1998
Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector.. 3. 1997
Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice.. 3. 1997
Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth.. 3. 1997
Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.. 3. 1997
Thymosin beta 15: a novel regulator of tumor cell motility upregulated in metastatic prostate cancer.. 2. 1996
Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo.. 2. 1996
Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis.. 1. 1995
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial.. 28. 2022
Publisher Correction: Microglial activation and tau propagate jointly across Braak stages.. 27. 2021
Author Correction: Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes.. 26. 2020
Publisher Correction: Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma.. 24. 2018
Publisher Correction: Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia.. 24. 2018
Corrigendum: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.. 24. 2018
Corrigendum: Sex-specific transcriptional signatures in human depression.. 24. 2018
Corrigendum: PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.. 22. 2016
Peroxiredoxin sets the brain on fire after stroke.. 18. 2012
Merging mitochondria for neuronal survival.. 13. 2007
Where lies the blame for resistance--tumor or host?. 13. 2007
Mycobacterium tuberculosis virulence: lipids inside and out.. 13. 2007
Seeing what Alzheimer saw.. 13. 2007
Alzheimer's APP mangles mitochondria.. 12. 2006
Cracking the fungal armor.. 12. 2006
Calculated resistance in cancer.. 11. 2005
Splitting vessels: keeping lymph apart from blood.. 9. 2003
TREM-1: a new regulator of innate immunity in sepsis syndrome.. 7. 2001
Harold Varmus [interview by Karen Birmingham].. 7. 2001
HIV-1 entry inhibitors: evading the issue.. 5. 1999
Arming T cells against B cells in systemic lupus erythematosus. 2022
Liquid biopsies and tumor mutational burden: the cutoff conundrum. 2022
Inching closer to precision treatment for rheumatoid arthritis. 2022
Artificial intelligence for disparities in knee pain assessment. 2021
Unlocking the genetic complexity of congenital hydrocephalus. 2020
Divergent effects of lipids on stroke. 2019
An exercise-induced messenger boosts memory in Alzheimer's disease. 2019
Tumors evading CARs-the chase is on. 2018
New machine-learning technologies for computer-aided diagnosis. 2018
A treatment strategy for KRAS-driven tumors. 2018
The enteric virome in hematopoietic stem cell transplantation: ready for its close-up. 2017
A broader spectrum of tuberculosis. 2016
Targeting a regulator of protein homeostasis in myeloproliferative neoplasms. 2016
Metabolic-epigenetic coupling in osteoclast differentiation. 2015
Another HIV vaccine failure: where to next? 2013
In cancer drug resistance, germline matters too. 2012
Locking out hepatitis C. 2011
Calling all antigens. 2010
Epstein-Barr virus sustains tumor killers. 2008
Eating bone or adding it: the Wnt pathway decides. 2007
Feeling pain? Who's your daddy... 2006
Rescuing troubled vessels in Alzheimer disease. 2005
Bone marrow spawns brain killers. 2004
TORward AKTually useful mouse models. 2004
Hemoglobin as a chariot for NO bioactivity. 2002
The skinny on CD39 in immunity and inflammation. 2002
From CSD to headache: a long and winding road. 2002
Monoclonal antibody therapies-a 'constant' threat to cancer. 2000
HIV-1 neutralizing antibodies: how full is the bottle? 1999
Refining the origins of breast cancer. 1995
AI-generated text may have a role in evidence-based medicine. 2023
The medicalization of freedom: how anti-science movements use the language of personal liberty and how we can address it. 2022
Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status". 2016
Colorectal cancer classification based on gene expression is not associated with FOLFIRI response. 2014
HIV-1 Env antibodies: are we in a bind or going blind? 2012
Large stem cell grafts could lead to erroneous interpretations of behavioral results? 2007
Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. 2002
HIV tropism and CD4+ T-cell depletion. 2002
Viral phenotype and CCR5 genotype. 1999
IL-6 release and airway administration of human CFR cDNA adenovirus vector. 1995
Cancer stem cells are everywhere.. 15. 2009
Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021. 2021
Reporting guidelines for human microbiome research: the STORMS checklist. 2021
Post-acute COVID-19 syndrome. 2021
Intratumoral heterogeneity in cancer progression and response to immunotherapy. 2021
Extrapulmonary manifestations of COVID-19. 2020
Joint international consensus statement for ending stigma of obesity. 2020
Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic. 2019
Understanding the tumor immune microenvironment (TIME) for effective therapy. 2018
Therapeutic targeting of splicing in cancer. 2016
Natural and therapy-induced immunosurveillance in breast cancer. 2015
Innate lymphoid cells in the initiation, regulation and resolution of inflammation. 2015
Tumor adaptation and resistance to RAF inhibitors. 2013
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies. 2013
The immunology of stroke: from mechanisms to translation. 2011
The biology of infertility: research advances and clinical challenges. 2008
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. 2007
Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. 2003
Modification of vascular responses in xenotransplantation: inflammation and apoptosis. 1997
Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families. 1996

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