British journal of pharmacology

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STAT1- and NFAT-independent amplification of purinoceptor function integrates cellular senescence with interleukin-6 production in preadipocytes.. 180. 2022
An in silico-in vitro pipeline for drug cardiotoxicity screening identifies ionic pro-arrhythmia mechanisms.. 179. 2022
Involvement of 3',5'-cyclic inosine monophosphate in cystathionine γ-lyase-dependent regulation of the vascular tone.. 178. 2021
Rosiglitazone alleviates intrahepatic cholestasis induced by α-naphthylisothiocyanate in mice: The role of circulating 15-deoxy-Δ^12,14 -PGJ₂ and Nogo.. 177. 2020
Anomalous K_v 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H₂ S and persulfidation in skeletal muscle.. 177. 2019
Erucin exhibits vasorelaxing effects and antihypertensive activity by H₂ S-releasing properties.. 177. 2019
A novel cross-species inhibitor to study the function of CatSper Ca²⁺ channels in sperm.. 175. 2018
The novel H₂ S donor 4-carboxy-phenyl isothiocyanate inhibits mast cell degranulation and renin release by decreasing intracellular calcium.. 173. 2016
Protective effect of the multitarget compound DPH-4 on human SSAO/VAP-1-expressing hCMEC/D3 cells under oxygen-glucose deprivation conditions: an in vitro experimental model of cerebral ischaemia.. 172. 2015
Cardiac responses to β-adrenoceptor stimulation is partly dependent on mitochondrial calcium uniporter activity.. 171. 2014
Proteinase-activated receptors 1 and 2 and the regulation of porcine coronary artery contractility: a role for distinct tyrosine kinase pathways.. 171. 2014
Targeting mitochondrial cardiolipin and the cytochrome c/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis.. 171. 2014
Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1.. 171. 2014
Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands.. 168. 2013
The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases in vitro drug delivery across blood-brain barrier cells.. 167. 2012
Perivascular adipose tissue-derived relaxing factors: release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms.. 164. 2011
Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids.. 162. 2011
Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels.. 161. 2010
Bidirectional modulation of isoflurane potency by intrathecal tetrodotoxin and veratridine in rats.. 159. 2010
A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries.. 157. 2009
Activation of peroxisome proliferator-activated receptor-alpha in mice induces expression of the hepatic low-density lipoprotein receptor.. 155. 2008
Defying the economists: a decrease in heart rate improves not only cardiac but also endothelial function.. 154. 2008
Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1.. 152. 2007
IP(3) receptor antagonist, 2-APB, attenuates cisplatin induced Ca2+-influx in HeLa-S3 cells and prevents activation of calpain and induction of apoptosis.. 151. 2007
Anti-adipogenic action of pitavastatin occurs through the coordinate regulation of PPARgamma and Pref-1 expression.. 151. 2007
Protective role of PI3-kinase-Akt-eNOS signalling pathway in intestinal injury associated with splanchnic artery occlusion shock.. 151. 2007
Endothelial dysfunction in the streptozotocin-induced diabetic apoE-deficient mouse.. 146. 2005
Enhanced vascular reactivity of small mesenteric arteries from diabetic mice is associated with enhanced oxidative stress and cyclooxygenase products.. 144. 2005
Modulation of voltage-gated channel currents by harmaline and harmane.. 144. 2005
Catalase has negligible inhibitory effects on endothelium-dependent relaxations in mouse isolated aorta and small mesenteric artery.. 140. 2003
Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice.. 140. 2003
A photosensitive vascular smooth muscle store of nitric oxide in mouse aorta: no dependence on expression of endothelial nitric oxide synthase.. 138. 2003
Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability.. 136. 2002
Kainate receptor-mediated apoptosis in primary cultures of cerebellar granule cells is attenuated by mitogen-activated protein and cyclin-dependent kinase inhibitors.. 135. 2002
Chronic fluoxetine treatment selectively uncouples raphe 5-HT(1A) receptors as measured by [(35)S]-GTP gamma S autoradiography.. 135. 2002
Multiple mechanisms of vascular smooth muscle relaxation by the activation of proteinase-activated receptor 2 in mouse mesenteric arterioles.. 135. 2002
Vascular smooth muscle relaxation mediated by nitric oxide donors: a comparison with acetylcholine, nitric oxide and nitroxyl ion.. 134. 2001
Vasorelaxant effects of a nitric oxide-releasing aspirin derivative in normotensive and hypertensive rats.. 133. 2001
Incorporation of sodium channel blocking and free radical scavenging activities into a single drug, AM-36, results in profound inhibition of neuronal apoptosis.. 132. 2001
Lack of involvement of endothelin-1 in angiotensin II-induced contraction of the isolated rat tail artery.. 131. 2000
Cannabinoid receptor-mediated inhibition of acetylcholine release from hippocampal and cortical synaptosomes.. 131. 2000
Nitric oxide and sodium nitroprusside-induced relaxation of the human umbilical artery.. 131. 2000
Comparison of the pharmacological properties of EDHF-mediated vasorelaxation in guinea-pig cerebral and mesenteric resistance vessels.. 130. 2000
Role of loop D of the alpha7 nicotinic acetylcholine receptor in its interaction with the insecticide imidacloprid and related neonicotinoids.. 130. 2000
Selective cyclo-oxygenase-2 inhibition with celecoxib elevates blood pressure and promotes leukocyte adherence.. 129. 2000
Potassium- and acetylcholine-induced vasorelaxation in mice lacking endothelial nitric oxide synthase.. 129. 2000
Acetylcholine-induced relaxation of peripheral arteries isolated from mice lacking endothelial nitric oxide synthase.. 128. 1999
Functional characterization and m-RNA expression of 5-HT receptors mediating contraction in human umbilical artery.. 127. 1999
Endothelium-dependent contractile actions of proteinase-activated receptor-2-activating peptides in human umbilical vein: release of a contracting factor via a novel receptor.. 125. 1998
Cyclic GMP-dependent and cyclic GMP-independent actions of nitric oxide on the renal afferent arteriole.. 125. 1998
Culture substrate-specific expression of P2Y2 receptors in distal lung epithelial cells isolated from foetal rats.. 124. 1998
Dual endothelium-dependent vascular activities of proteinase-activated receptor-2-activating peptides: evidence for receptor heterogeneity.. 123. 1998
Roles of calcium-activated and voltage-gated delayed rectifier potassium channels in endothelium-dependent vasorelaxation of the rabbit middle cerebral artery.. 123. 1998
Cardiovascular effects of CPU-23, a novel L-type calcium channel blocker with a unique molecular structure.. 122. 1997
NO/PGI2-independent vasorelaxation and the cytochrome P450 pathway in rabbit carotid artery.. 120. 1997
Inhibition by propofol of [3H]-batrachotoxinin-A 20-alpha-benzoate binding to voltage-dependent sodium channels in rat cortical synaptosomes.. 119. 1996
Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform.. 118. 1996
Nitric oxide, a possible mediator of 1,4-dihydropyridine-induced photorelaxation of vascular smooth muscle.. 118. 1996
Photosensitization of oesophageal smooth muscle by 3-NO2-1, 4-dihydropyridines: evidence for two cyclic GMP-dependent effector pathways.. 116. 1995
Mechanism of bile salt vasoactivity: dependence on calcium channels in vascular smooth muscle.. 112. 1994
The effects of perfusion rate and NG-nitro-L-arginine methyl ester on cirazoline- and KCl-induced responses in the perfused mesenteric arterial bed of rats.. 111. 1994
The effects of alpha-adrenoceptor agonists on intracellular Ca2+ levels in freshly dispersed single smooth muscle cells from rat tail artery.. 109. 1993
Interactions of nitric oxide synthase inhibitors and dexamethasone with alpha-adrenoceptor-mediated responses in rat aorta.. 109. 1993
Calcium antagonizes the magnesium-induced high affinity state of the hepatic vasopressin receptor for the agonist interaction.. 100. 1990
Inhibition of field stimulation-evoked relaxations in rat oesophageal smooth muscle by the calcium antagonist PN 200-110.. 95. 1988
Similarity of relaxations evoked by BRL 34915, pinacidil and field-stimulation in rat oesophageal tunica muscularis mucosae.. 95. 1988
Electrophysiological effects of acetyl glyceryl ether phosphorylcholine on cardiac tissues: comparison with lysophosphatidylcholine and long chain acyl carnitine.. 89. 1986
Pharmacological studies with SK&F 93944 (temelastine), a novel histamine H1-receptor antagonist with negligible ability to penetrate the central nervous system.. 87. 1986
Pharmacological properties of mechanical responses of the rat oesophageal muscularis mucosae to vagal and field stimulation.. 84. 1985
Inhibition of thromboxane A2 biosynthesis in human platelets by burimamide.. 71. 1980
Potential protective value of enhanced myocardial carbohydrate utilisation with reduced free fatty acid uptake after UK 25842 in patients with coronary artery disease [proceedings].. 66. 1979
Anaphylaxis in the guinea-pig isolated heart: selective inhibition by burimamide of the positive inotropic and chronotropic effects of released histamine.. 48. 1973
Neuromuscular blocking activity of a new series of quaternary N-substituted choline esters.. 43. 1971
Understanding the interaction between leukaemia stem cells and their microenvironment to improve therapeutic approaches. 2023
Mesenchymal stem cells and cancer-associated fibroblasts as a therapeutic strategy for breast cancer. 2022
Possible mechanisms of cancer prevention by nicotinamide. 2020
Perivascular adipose tissue from human systemic and coronary vessels: the emergence of a new pharmacotherapeutic target. 2012

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British journal of pharmacology Journal

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