Cyclooxygenase-2 immunoreactivity in the human brain following cerebral ischemia. Academic Article uri icon

Overview

abstract

  • The prostaglandin synthesizing enzyme cyclooxygenase-2 (COX-2) is up-regulated in the brain of rodents during cerebral ischemia and contributes to ischemic brain injury. This study sought to determine whether COX-2 is also up-regulated in the human brain in the acute stages of cerebral ischemic infarction. Paraffin-embedded sections from patients who died 1-2 days following infarction in the middle cerebral artery territory were processed for COX-2 immunohistochemistry. COX-2 immunoreactivity was observed in infiltrating neutrophils, in vascular cells and in neurons located at the border of the infarct. The data suggest that COX-2 up-regulation is also relevant to cerebral ischemia in humans and raise the possibility that COX-2 reaction products participate in the mechanisms of ischemic injury also in the human brain.

publication date

  • July 1, 1999

Research

keywords

  • Brain
  • Brain Ischemia
  • Isoenzymes
  • Prostaglandin-Endoperoxide Synthases

Identity

Scopus Document Identifier

  • 0033043532

Digital Object Identifier (DOI)

  • 10.1007/s004010051045

PubMed ID

  • 10412795

Additional Document Info

volume

  • 98

issue

  • 1