Role of leukocyte influx in tissue prostaglandin H synthase-2 overexpression induced by phorbol ester and arachidonic acid in skin. Academic Article uri icon

Overview

abstract

  • The accumulation of neutrophils and mononuclear cells is a characteristic feature of 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear edema. This cell influx was accompanied by the enhancement of eicosanoid tissue levels and prostaglandin H synthase-2 (PGHS-2) overexpression. Sialidase treatment, which affects the structure of selectins and inhibits leukocyte influx, significantly reduced eicosanoid and PGHS-2 levels and edema. In contrast, skin PGHS-2 overexpression induced by arachidonic acid (AA) application was not affected by sialidase treatment. These results suggest that PGHS-2 overexpression induced by TPA could be induced by AA and/or AA metabolite release by leukocyte infiltrated during the inflammatory process.

publication date

  • September 1, 1999

Research

keywords

  • Arachidonic Acid
  • Isoenzymes
  • Leukocytes
  • Prostaglandin-Endoperoxide Synthases
  • Skin
  • Tetradecanoylphorbol Acetate

Identity

Scopus Document Identifier

  • 0344759120

Digital Object Identifier (DOI)

  • 10.1016/s0006-2952(99)00169-0

PubMed ID

  • 10449199

Additional Document Info

volume

  • 58

issue

  • 5