Hepatocellular transport and secretion of biliary lipids. Review uri icon

Overview

abstract

  • Bile is the route for elimination of cholesterol from the body. Recent studies have begun to elucidate hepatocellular, molecular and physical-chemical mechanisms whereby bile salts stimulate biliary secretion of cholesterol together with phospholipids, which are enriched (up to 95%) in phosphatidylcholines. Active translocation of bile salts and phosphatidylcholines across the hepatocyte's canalicular plasma membrane provides the driving force for biliary lipid secretion. This facilitates physical-chemical interactions between detergent-like bile salt molecules and the ectoplasmic leaflet of the canalicular membrane, which result in biliary secretion of cholesterol and phosphatidylcholines as vesicles. Within the hepatocyte, separate molecular pathways function to resupply bile salts, phosphatidylcholines and cholesterol to the canalicular membrane for ongoing biliary lipid secretion.

publication date

  • August 1, 1999

Research

keywords

  • Biliary Tract
  • Lipid Metabolism
  • Liver

Identity

Scopus Document Identifier

  • 0032825785

Digital Object Identifier (DOI)

  • 10.1097/00041433-199908000-00002

PubMed ID

  • 10482131

Additional Document Info

volume

  • 10

issue

  • 4