The role of self-recognition in receptor repertoire development. Members of the Janeway Laboratory. Review uri icon

Overview

abstract

  • The role of self-antigen recognition in the development of T and B cells of the adaptive immune system has been studied in several different ways. We have shown that CD4 T cells are selected on self-peptide:self-MHC class II ligands, and in the periphery, they are sustained by contact with the same or similar ligands. We have also observed that B cells are positively selected on unknown and presumed self-ligands. We have used this information to explore autoimmune diseases as well. Finally, we have recently identified the innate immune system as playing a crucial role in regulating expression of costimulatory molecules that are required for induction of adaptive immune responses.

publication date

  • January 1, 1999

Research

keywords

  • Autoantigens
  • Receptors, Antigen, B-Cell
  • Receptors, Antigen, T-Cell

Identity

Scopus Document Identifier

  • 0032771049

Digital Object Identifier (DOI)

  • 10.1007/BF02786480

PubMed ID

  • 10493166

Additional Document Info

volume

  • 19

issue

  • 2-3