Rudensky, Alexander

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selected publications

Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism. Cell metabolism. 2019 Review GET IT
Times cited: 52
IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus. The Journal of experimental medicine. 2019 Academic Article GET IT
Times cited: 49
Mouse Watch: A Cautionary Tale. Immunity. 2019 Comment GET IT
Times cited: 3
Author Correction: An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses. Nature communications. 2018 Academic Article GET IT
Times cited: 10
Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance. Immunity. 2018 Academic Article GET IT
Times cited: 79
BRCT-domain protein BRIT1 influences class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 3
Stability and function of regulatory T cells expressing the transcription factor T-bet. Nature. 2017 Academic Article GET IT
Times cited: 217
The aryl hydrocarbon receptor controls cell-fate decisions in B cells. The Journal of experimental medicine. 2016 Academic Article GET IT
Times cited: 69
Basophils Promote Tumor Rejection via Chemotaxis and Infiltration of CD8+ T Cells. Cancer research. 2016 Academic Article GET IT
Times cited: 57
Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer. Immunity. 2016 Academic Article GET IT
Times cited: 380
An essential role for the IL-2 receptor in T_reg cell function. Nature immunology. 2016 Academic Article GET IT
Times cited: 471
Regulatory T Cells: Differentiation and Function. Cancer immunology research. 2016 Review GET IT
Times cited: 169
Memory of Inflammation in Regulatory T Cells. Cell. 2016 Academic Article GET IT
Times cited: 108
T cell receptor signalling in the control of regulatory T cell differentiation and function. Nature reviews. Immunology. 2016 Review GET IT
Times cited: 312
Hallmarks of Tissue-Resident Lymphocytes. Cell. 2016 Review GET IT
Times cited: 243
Pillars Article: Sequence Analysis of Peptides Bound to MHC Class II Molecules. Nature. 1991. 353: 622-627. Journal of immunology (Baltimore, Md. : 1950). 2016 Review GET IT
miR-23∼27∼24 clusters control effector T cell differentiation and function. The Journal of experimental medicine. 2016 Academic Article GET IT
Times cited: 104
A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance. Nature. 2015 Academic Article GET IT
Times cited: 111
Immune homeostasis enforced by co-localized effector and regulatory T cells. Nature. 2015 Academic Article GET IT
Times cited: 207
Genetic and epigenetic variation in the lineage specification of regulatory T cells. eLife. 2015 Academic Article GET IT
Times cited: 40
Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs. Science (New York, N.Y.). 2015 Academic Article GET IT
Times cited: 539
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity. The Journal of experimental medicine. 2015 Academic Article GET IT
Times cited: 160
A Distinct Function of Regulatory T Cells in Tissue Protection. Cell. 2015 Academic Article GET IT
Times cited: 610
A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner. Immunity. 2015 Academic Article GET IT
Times cited: 136
Reigning in regulatory T-cell function. Nature biotechnology. 2015 Comment GET IT
Times cited: 2
The Cell-Intrinsic Circadian Clock Is Dispensable for Lymphocyte Differentiation and Function. Cell reports. 2015 Academic Article GET IT
Times cited: 67
Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution. Science (New York, N.Y.). 2014 Academic Article GET IT
Times cited: 174
A comparative encyclopedia of DNA elements in the mouse genome. Nature. 2014 Academic Article GET IT
Times cited: 1071
Continuous requirement for the TCR in regulatory T cell function. Nature immunology. 2014 Academic Article GET IT
Times cited: 368
Interactions between innate and adaptive lymphocytes. Nature reviews. Immunology. 2014 Review GET IT
Times cited: 156
Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus. Cell. 2014 Academic Article GET IT
Times cited: 278
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. The Journal of experimental medicine. 2014 Academic Article GET IT
Times cited: 163
Transcriptional control of regulatory T-cell differentiation. Cold Spring Harbor symposia on quantitative biology. 2014 Review GET IT
Times cited: 20
Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells. Nature immunology. 2014 Academic Article GET IT
Times cited: 165
Regulatory T cell ablation causes acute T cell lymphopenia. PloS one. 2014 Academic Article GET IT
Times cited: 13
Microbial metabolites control gut inflammatory responses. Proceedings of the National Academy of Sciences of the United States of America. 2014 Comment GET IT
Times cited: 72
Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon. Nature communications. 2014 Academic Article GET IT
Times cited: 112
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013 Academic Article GET IT
Times cited: 2810
Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy. The Journal of experimental medicine. 2013 Academic Article GET IT
Times cited: 205
The plasticity and stability of regulatory T cells. Nature reviews. Immunology. 2013 Academic Article GET IT
Times cited: 388
IL-2-dependent adaptive control of NK cell homeostasis. The Journal of experimental medicine. 2013 Academic Article GET IT
Times cited: 96
IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. The Journal of experimental medicine. 2013 Academic Article GET IT
Times cited: 126
Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 91
Control of inflammation by integration of environmental cues by regulatory T cells. The Journal of clinical investigation. 2013 Review GET IT
Times cited: 142
Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting. Molecular cell. 2012 Academic Article GET IT
Times cited: 257
Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature. 2012 Academic Article GET IT
Times cited: 297
Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification. Cell. 2012 Academic Article GET IT
Times cited: 353
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. The Journal of experimental medicine. 2012 Academic Article GET IT
Times cited: 473
Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nature immunology. 2012 Academic Article GET IT
Times cited: 330
Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell. 2012 Academic Article GET IT
Times cited: 463
An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes. Immunity. 2012 Academic Article GET IT
Times cited: 92
Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature. 2012 Academic Article GET IT
Times cited: 644
Regulatory T cells: mechanisms of differentiation and function. Annual review of immunology. 2012 Review GET IT
Times cited: 2036
The effects of commensal microbiota on immune cell subsets and inflammatory responses. Immunological reviews. 2012 Review GET IT
Times cited: 83
A narrow circle of mutual friends. Immunity. 2011 Comment GET IT
Times cited: 7
Regulatory T cells and Foxp3. Immunological reviews. 2011 Review GET IT
Times cited: 584
Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity. 2011 Academic Article GET IT
Times cited: 673
Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity. 2011 Academic Article GET IT
Times cited: 473
Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation. Immunity. 2011 Academic Article GET IT
Times cited: 203
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells. Nature communications. 2011 Academic Article GET IT
Times cited: 152
A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota. The Journal of experimental medicine. 2010 Academic Article GET IT
Times cited: 96
Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway. The Journal of experimental medicine. 2010 Academic Article GET IT
Times cited: 375
Stability of the regulatory T cell lineage in vivo. Science (New York, N.Y.). 2010 Academic Article GET IT
Times cited: 529
Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell. 2010 Academic Article GET IT
Times cited: 759
Th17 and regulatory T cells in mediating and restraining inflammation. Cell. 2010 Review GET IT
Times cited: 807
IPS-1 is essential for the control of West Nile virus infection and immunity. PLoS pathogens. 2010 Academic Article GET IT
Times cited: 182
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature. 2010 Academic Article GET IT
Times cited: 884
Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 138
Tregs control the development of symptomatic West Nile virus infection in humans and mice. The Journal of clinical investigation. 2009 Academic Article GET IT
Times cited: 174
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science (New York, N.Y.). 2009 Academic Article GET IT
Times cited: 799
Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nature immunology. 2009 Academic Article GET IT
Times cited: 161
Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. The Journal of experimental medicine. 2009 Academic Article GET IT
Times cited: 333
Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse. Journal of autoimmunity. 2009 Academic Article GET IT
Times cited: 51
Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 130
Intraclonal competition limits the fate determination of regulatory T cells in the thymus. Nature immunology. 2009 Academic Article GET IT
Times cited: 201
Molecular orchestration of differentiation and function of regulatory T cells. Genes & development. 2009 Academic Article GET IT
Times cited: 64
Control of regulatory T cell lineage commitment and maintenance. Immunity. 2009 Review GET IT
Times cited: 458
Editorial overview: lymphocyte development. Current opinion in immunology. 2009 Editorial Article GET IT
Times cited: 2
In vivo analysis of dendritic cell development and homeostasis. Science (New York, N.Y.). 2009 Academic Article GET IT
Times cited: 758
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature. 2009 Academic Article GET IT
Times cited: 734
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity. 2009 Academic Article GET IT
Times cited: 668
Dicer-dependent microRNA pathway safeguards regulatory T cell function. The Journal of experimental medicine. 2008 Academic Article GET IT
Times cited: 344
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. The Journal of experimental medicine. 2008 Academic Article GET IT
Times cited: 311
Differentiation of regulatory Foxp3+ T cells in the thymic cortex. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 177
Coordination of early protective immunity to viral infection by regulatory T cells. Science (New York, N.Y.). 2008 Academic Article GET IT
Times cited: 358
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity. 2008 Academic Article GET IT
Times cited: 1152
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature. 2008 Academic Article GET IT
Times cited: 1540
G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells. Molecular and cellular biology. 2007 Academic Article GET IT
Times cited: 22
Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 311
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nature immunology. 2007 Academic Article GET IT
Times cited: 472
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease. The Journal of clinical investigation. 2007 Academic Article GET IT
Times cited: 179
Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 327
TGFbeta signalling in control of T-cell-mediated self-reactivity. Nature reviews. Immunology. 2007 Review GET IT
Times cited: 271
Foxp3 in control of the regulatory T cell lineage. Nature immunology. 2007 Review GET IT
Times cited: 568
Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 169
Effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 Academic Article GET IT
Times cited: 69
Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. Journal of immunology (Baltimore, Md. : 1950). 2007 Academic Article GET IT
Times cited: 113
Lack of Foxp3 function and expression in the thymic epithelium. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 55
Thymic development and peripheral homeostasis of regulatory T cells. Current opinion in immunology. 2007 Review GET IT
Times cited: 127
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature. 2007 Academic Article GET IT
Times cited: 702
Foxp3-dependent programme of regulatory T-cell differentiation. Nature. 2007 Academic Article GET IT
Times cited: 928
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nature immunology. 2007 Academic Article GET IT
Times cited: 695
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nature immunology. 2006 Academic Article GET IT
Times cited: 1348
Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity. 2006 Academic Article GET IT
Times cited: 387
The role of the transcription factor Foxp3 in the development of regulatory T cells. Immunological reviews. 2006 Review GET IT
Times cited: 147
FOXP3 and NFAT: partners in tolerance. Cell. 2006 Comment GET IT
Times cited: 86
Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 633
In vivo sites and cellular mechanisms of T reg cell-mediated suppression. The Journal of experimental medicine. 2006 Comment GET IT
Times cited: 93
An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nature immunology. 2006 Academic Article GET IT
Times cited: 425
Lysosomal cysteine proteases and antigen presentation. Ernst Schering Research Foundation workshop. 2006 Review GET IT
Times cited: 38
A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nature immunology. 2005 Academic Article GET IT
Times cited: 1438
Developmental regulation of Foxp3 expression during ontogeny. The Journal of experimental medicine. 2005 Academic Article GET IT
Times cited: 339
The lysosomal cysteine proteases in MHC class II antigen presentation. Immunological reviews. 2005 Review GET IT
Times cited: 265
Foxp3 and dominant tolerance. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2005 Academic Article GET IT
Times cited: 24
Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: the interplay of clonal anergy and immune regulation. Journal of immunology (Baltimore, Md. : 1950). 2005 Academic Article GET IT
Times cited: 75
Regulation of immunity by self-reactive T cells. Nature. 2005 Review GET IT
Times cited: 259
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. The Journal of experimental medicine. 2005 Academic Article GET IT
Times cited: 842
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nature immunology. 2005 Review GET IT
Times cited: 834
Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity. 2005 Academic Article GET IT
Times cited: 1928
Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivo. Journal of immunology (Baltimore, Md. : 1950). 2005 Academic Article GET IT
Times cited: 95
The role of TCR specificity in naturally arising CD25+ CD4+ regulatory T cell biology. Current topics in microbiology and immunology. 2005 Review GET IT
Times cited: 21
Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM). Blood. 2004 Academic Article GET IT
Times cited: 108
Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity. 2004 Academic Article GET IT
Times cited: 600
Effect of decreasing the affinity of the class II-associated invariant chain peptide on the MHC class II peptide repertoire in the presence or absence of H-2M. Journal of immunology (Baltimore, Md. : 1950). 2004 Academic Article GET IT
Times cited: 15
Molecular aspects of regulatory T cell development. Seminars in immunology. 2004 Review GET IT
Times cited: 53
Control of immune homeostasis by naturally arising regulatory CD4+ T cells. Current opinion in immunology. 2003 Review GET IT
Times cited: 167
A goodbye to Charlie Janeway: Charles A. Janeway Jr (1943-2003). Trends in immunology. 2003 Academic Article GET IT
Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. Immunity. 2003 Academic Article GET IT
Times cited: 592
Lysosomal cysteine proteases regulate antigen presentation. Nature reviews. Immunology. 2003 Review GET IT
Times cited: 357
Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation. Blood. 2003 Academic Article GET IT
Times cited: 90
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nature immunology. 2003 Academic Article GET IT
Times cited: 6171
Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif. Journal of molecular biology. 2003 Academic Article GET IT
Times cited: 75
Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages. The Journal of experimental medicine. 2003 Academic Article GET IT
Times cited: 90
Antigen-specific dose-dependent system for the study of an inheritable and reversible phenotype in mouse CD4+ T cells. Immunology. 2002 Academic Article GET IT
Times cited: 15
The balance between donor T cell anergy and suppression versus lethal graft-versus-host disease is determined by host conditioning. Journal of immunology (Baltimore, Md. : 1950). 2002 Academic Article GET IT
Times cited: 38
Regulation of thymic epithelium by keratinocyte growth factor. Blood. 2002 Academic Article GET IT
Times cited: 124
Thymocyte expression of cathepsin L is essential for NKT cell development. Nature immunology. 2002 Academic Article GET IT
Times cited: 96
Characterization of mouse and human B7-H3 genes. Journal of immunology (Baltimore, Md. : 1950). 2002 Academic Article GET IT
Times cited: 215
Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands. The Journal of experimental medicine. 2002 Academic Article GET IT
Times cited: 158
Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes. Proceedings of the National Academy of Sciences of the United States of America. 2002 Academic Article GET IT
Times cited: 19
A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentation. Journal of immunology (Baltimore, Md. : 1950). 2002 Academic Article GET IT
Times cited: 142
Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nature immunology. 2001 Academic Article GET IT
Times cited: 556
Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells. The Journal of cell biology. 2001 Academic Article GET IT
Times cited: 240
Efficient presentation of both cytosolic and endogenous transmembrane protein antigens on MHC class II is dependent on cytoplasmic proteolysis. Journal of immunology (Baltimore, Md. : 1950). 2001 Academic Article GET IT
Times cited: 58
The pIV-otal class II transactivator promoter regulates major histocompatibility complex class II expression in the thymus. The Journal of experimental medicine. 2001 Comment GET IT
Times cited: 7
Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands. The Journal of experimental medicine. 2001 Academic Article GET IT
Times cited: 99
In vivo MHC class II presentation of cytosolic proteins revealed by rapid automated tandem mass spectrometry and functional analyses. European journal of immunology. 2001 Academic Article GET IT
Times cited: 115
Cathepsin S regulates the expression of cathepsin L and the turnover of gamma-interferon-inducible lysosomal thiol reductase in B lymphocytes. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 45
The CD4 T cell-deficient mouse mutation nackt (nkt) involves a deletion in the cathepsin L (CtsI) gene. Immunogenetics. 2001 Academic Article GET IT
Times cited: 26
Survival and homeostatic proliferation of naive peripheral CD4+ T cells in the absence of self peptide:MHC complexes. Journal of immunology (Baltimore, Md. : 1950). 2000 Academic Article GET IT
Times cited: 139
Competition for specific intrathymic ligands limits positive selection in a TCR transgenic model of CD4+ T cell development. Journal of immunology (Baltimore, Md. : 1950). 2000 Academic Article GET IT
Times cited: 33
Dynamic interactions of macrophages with T cells during antigen presentation. The Journal of experimental medicine. 1999 Academic Article GET IT
Times cited: 111
Evaluating peptide repertoires within the context of thymocyte development. Seminars in immunology. 1999 Review GET IT
Times cited: 13
The role of lysosomal proteinases in MHC class II-mediated antigen processing and presentation. Immunological reviews. 1999 Review GET IT
Times cited: 161
Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. Immunity. 1999 Academic Article GET IT
Times cited: 372
Peptide loading in the endoplasmic reticulum accelerates trafficking of peptide:MHC class II complexes in B cells. Journal of biomedical science. 1999 Academic Article GET IT
Times cited: 4
Requirement for diverse, low-abundance peptides in positive selection of T cells. Science (New York, N.Y.). 1999 Academic Article GET IT
Times cited: 95
The role of self-recognition in receptor repertoire development. Members of the Janeway Laboratory. Immunologic research. 1999 Review GET IT
Times cited: 13
Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides. Proceedings of the National Academy of Sciences of the United States of America. 1998 Academic Article GET IT
Times cited: 39
An altered invariant chain protein with an antigenic peptide in place of CLIP forms SDS-stable complexes with class II alphabeta dimers and facilitates highly efficient peptide loading. International immunology. 1998 Academic Article GET IT
Times cited: 16
Medullary thymic epithelium: a mosaic of epithelial "self"?. The Journal of experimental medicine. 1998 Academic Article GET IT
Times cited: 62
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science (New York, N.Y.). 1998 Academic Article GET IT
Times cited: 593
Mtv-1 superantigen trafficks independently of major histocompatibility complex class II directly to the B-cell surface by the exocytic pathway. Journal of virology. 1998 Academic Article GET IT
Times cited: 9
Altered antigen presentation in mice lacking H2-O. Immunity. 1998 Academic Article GET IT
Times cited: 160
Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. The Journal of experimental medicine. 1998 Academic Article GET IT
Times cited: 50
Trypanosoma cruzi-infected macrophages are defective in major histocompatibility complex class II antigen presentation. European journal of immunology. 1997 Academic Article GET IT
Times cited: 33
Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartments. The Journal of cell biology. 1997 Academic Article GET IT
Times cited: 198
Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice. Journal of immunology (Baltimore, Md. : 1950). 1997 Academic Article GET IT
Times cited: 392
Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity. 1997 Academic Article GET IT
Times cited: 189
Presentation of abundant endogenous class II DR-restricted antigens by DM-negative B cell lines. European journal of immunology. 1997 Academic Article GET IT
Times cited: 17
Assembly of an abundant endogenous major histocompatibility complex class II/peptide complex in class II compartments. European journal of immunology. 1997 Academic Article GET IT
Times cited: 15
Differential expression of CLIP:MHC class II and conventional endogenous peptide:MHC class II complexes by thymic epithelial cells and peripheral antigen-presenting cells. European journal of immunology. 1996 Academic Article GET IT
Times cited: 26
Phenotype and function of CD4+ T cells in mice lacking invariant chain. Journal of immunology (Baltimore, Md. : 1950). 1996 Academic Article GET IT
Times cited: 30
Variation in HLA-DM expression influences conversion of MHC class II alpha beta:class II-associated invariant chain peptide complexes to mature peptide-bound class II alpha beta dimers in a normal B cell line. Journal of immunology (Baltimore, Md. : 1950). 1996 Academic Article GET IT
Times cited: 28
A study of complexes of class II invariant chain peptide: major histocompatibility complex class II molecules using a new complex-specific monoclonal antibody. European journal of immunology. 1996 Academic Article GET IT
Times cited: 53
Truncation of the class II beta-chain cytoplasmic domain influences the level of class II/invariant chain-derived peptide complexes. Proceedings of the National Academy of Sciences of the United States of America. 1996 Academic Article GET IT
Times cited: 20
Endogenous peptides associated with MHC class II and selection of CD4 T cells. Seminars in immunology. 1995 Review GET IT
Times cited: 9
T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates. The Journal of experimental medicine. 1995 Academic Article GET IT
Times cited: 54
Requirement for peptide in alloreactive CD4+ T cell recognition of class II MHC molecules. Journal of immunology (Baltimore, Md. : 1950). 1995 Academic Article GET IT
Times cited: 39
Presentation and intercellular transfer of self antigen within the thymic microenvironment: expression of the E alpha peptide-I-Ab complex by isolated thymic stromal cells. International immunology. 1994 Academic Article GET IT
Times cited: 36
Intracellular assembly and transport of endogenous peptide-MHC class II complexes. Immunity. 1994 Academic Article GET IT
Times cited: 112
Rules for peptide presentation by MHC class II molecules. International reviews of immunology. 1993 Review GET IT
Times cited: 7
Studies on naturally processed peptides associated with MHC class II molecules. Chemical immunology. 1993 Review GET IT
Times cited: 18
Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs. Nature. 1992 Academic Article GET IT
Times cited: 232
T and B cell receptors discriminate major histocompatibility complex class II conformations influenced by the invariant chain. European journal of immunology. 1992 Academic Article GET IT
Times cited: 24
Monoclonal antibody detection of a major self peptide. MHC class II complex. Journal of immunology (Baltimore, Md. : 1950). 1992 Academic Article GET IT
Times cited: 112
It is easier for a camel to pass the needle's eye. Current biology : CB. 1992 Academic Article GET IT
Times cited: 19
On the complexity of self. Nature. 1991 Academic Article GET IT
Times cited: 241
Sequence analysis of peptides bound to MHC class II molecules. Nature. 1991 Academic Article GET IT
Times cited: 953
[Obtaining human recombinant (serine-17) beta-interferon by the method of oligonucleotide-directed mutagenesis and its expression in Escherichia coli]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 1991 Academic Article GET IT
Presentation of endogenous immunoglobulin determinant to immunoglobulin-recognizing T cell clones by the thymic cells. European journal of immunology. 1990 Academic Article GET IT
Times cited: 26
Immunoglobulin-specific T-B cell interaction. IV. B cell presentation of idiotypic determinant(s) of monoclonal anti-surface immunoglobulin antibody to idiotope-recognizing helper T clones. European journal of immunology. 1990 Academic Article GET IT
Times cited: 18
Immunoglobulin-specific T-B cell interaction. III. B cell activation by immunoglobulin-recognizing T cell clones. European journal of immunology. 1990 Academic Article GET IT
Times cited: 14
Immunoglobulin-specific T-B cell interaction. I. Presentation of self immunoglobulin determinants by B lymphocytes. European journal of immunology. 1989 Academic Article GET IT
Times cited: 32
Immunoglobulin-specific T-B cell interaction. II. T cell clones recognize the processed form of B cells' own surface immunoglobulin in the context of the major histocompatibility complex class II molecule. European journal of immunology. 1989 Academic Article GET IT
Times cited: 45

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Background

education and training

Ph.D., Gabrichevsky Institute for Epidemiology and Microbiology (Russia) 1986
M.S., Second Moscow State Medical Institute (Russia) 1979

Contact

full name

Alexander Rudensky

primary email

rudenska@mskcc.org

VIVO Weill Cornell Medical College

Alexander Rudensky Tri-Institutional Professor

Publications

selected publications

Background

education and training

Contact

full name

primary email