Suppression of macrophage responses to bacterial lipopolysaccharide by a non-secretory form of secretory leukocyte protease inhibitor. Academic Article uri icon

Overview

abstract

  • Expression of secretory leukocyte protease inhibitor (SLPI) suppresses the ability of macrophages to respond to bacterial lipopolysaccharide (LPS). Here, addition of recombinant or native SLPI to the extracellular medium was non-suppressive, while transfection with a non-secretory form of SLPI was fully suppressive, an effect overcome by treatment with interferon-gamma. A portion of the SLPI produced by untransfected macrophages was localized in the cytosol. Thus, SLPI can act intracellularly to block macrophage activation by LPS.

publication date

  • September 21, 1999

Research

keywords

  • Lipopolysaccharides
  • Macrophages
  • Proteins
  • Serine Proteinase Inhibitors

Identity

Scopus Document Identifier

  • 0032746996

Digital Object Identifier (DOI)

  • 10.1016/s0167-4889(99)00111-1

PubMed ID

  • 10556576

Additional Document Info

volume

  • 1451

issue

  • 2-3