Interactions between nutritional factors and drug biotransformations in man. Academic Article uri icon

Overview

abstract

  • This study was undertaken to examine the influence of nutritional factors on the activity of the mixed function oxidase system in man, which is cytochrome P-450 dependent. Three normal volunteers were fed a low carbohydrate-high protein diet for 2 weeks, followed by a high carbohydrate-low protein diet for the follwoing 2 weeks. At the end of each test diet period, the plasma elimination rates of antipyrine and theophylline were determined. The mean plasma half-life for antipyrine was 17.5 hr on the high carbohydrate-low protein diet and 9.2 hr on the low carbohydrate-high protein diet. The mean plasma half-life for theophylline was 8.9 hr on the high carbohydrate-low protein diet and 5.9 hr on the low carbohydrate-high protein diet. These data demonstrate marked influences of dietary carbohydrate and/or protein ingestion on oxidative biotransformation of drugs in man.

publication date

  • July 1, 1976

Research

keywords

  • Antipyrine
  • Dietary Carbohydrates
  • Dietary Proteins
  • Mixed Function Oxygenases
  • Oxidoreductases
  • Theophylline

Identity

PubMed Central ID

  • PMC430624

Scopus Document Identifier

  • 2842545521

Digital Object Identifier (DOI)

  • 10.1073/pnas.73.7.2501

PubMed ID

  • 1065903

Additional Document Info

volume

  • 73

issue

  • 7