Reactive nitrogen intermediates and the pathogenesis of Salmonella and mycobacteria. Review uri icon

Overview

abstract

  • Over the past decade, reactive nitrogen intermediates joined reactive oxygen intermediates as a biochemically parallel and functionally non-redundant pathway for mammalian host resistance to many microbial pathogens. The past year has brought a new appreciation that these two pathways are partially redundant, such that each can compensate in part for the absence of the other. In combination, their importance to defense of the murine host is greater than previously appreciated. In addition to direct microbicidal actions, reactive nitrogen intermediates have immunoregulatory effects relevant to the control of infection. Genes have been characterized in Mycobacterium tuberculosis and Salmonella typhimurium that may regulate the ability of pathogens to resist reactive nitrogen and oxygen intermediates produced by activated macrophages.

publication date

  • February 1, 2000

Research

keywords

  • Mycobacterium tuberculosis
  • Nitric Oxide
  • Salmonella typhimurium

Identity

Scopus Document Identifier

  • 0033968059

Digital Object Identifier (DOI)

  • 10.1016/s1369-5274(99)00048-x

PubMed ID

  • 10679417

Additional Document Info

volume

  • 3

issue

  • 1