Nathan, Carl F.

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Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance. Cell chemical biology. 2023 Academic Article GET IT
Times cited: 1
Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II. Journal of medicinal chemistry. 2023 Academic Article GET IT
Transcriptional Biomarkers of Differentially Detectable Mycobacterium tuberculosis in Patient Sputum. mBio. 2022 Academic Article GET IT
Nonresolving inflammation redux. Immunity. 2022 Review GET IT
Times cited: 19
Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions. ACS infectious diseases. 2022 Academic Article GET IT
Times cited: 10
In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas. Journal of medicinal chemistry. 2022 Academic Article GET IT
Times cited: 3
Oxidative damage and delayed replication allow viable Mycobacterium tuberculosis to go undetected. Science translational medicine. 2021 Academic Article GET IT
Times cited: 8
Tres Cantos Open Lab: celebrating a decade of innovation in collaboration to combat endemic infectious diseases. Nature reviews. Drug discovery. 2021 Article GET IT
Times cited: 2
Characterization of Phosphopantetheinyl Hydrolase from Mycobacterium tuberculosis. Microbiology spectrum. 2021 Academic Article GET IT
Multiform antimicrobial resistance from a metabolic mutation. Science advances. 2021 Academic Article GET IT
Times cited: 14
The Tuberculosis Drug Accelerator at year 10: what have we learned?. Nature medicine. 2021 Academic Article GET IT
Times cited: 22
Characterization of Differentially Detectable Mycobacterium tuberculosis in the Sputum of Subjects with Drug-Sensitive or Drug-Resistant Tuberculosis before and after Two Months of Therapy. Antimicrobial agents and chemotherapy. 2021 Academic Article GET IT
Times cited: 9
Cellular blue nevus tumor presenting as a submandibular lymph node in a 16-year-old. 2021 GET IT
Noncytotoxic Inhibition of the Immunoproteasome Regulates Human Immune Cells In Vitro and Suppresses Cutaneous Inflammation in the Mouse. Journal of immunology (Baltimore, Md. : 1950). 2021 Academic Article GET IT
Times cited: 5
Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis. Nature communications. 2021 Academic Article GET IT
Times cited: 18
Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions. ACS infectious diseases. 2021 Academic Article GET IT
Type I interferon signaling mediates Mycobacterium tuberculosis-induced macrophage death. The Journal of experimental medicine. 2021 Academic Article GET IT
Times cited: 47
A Multistress Model for High Throughput Screening Against Nonreplicating Mycobacterium tuberculosis. Methods in molecular biology (Clifton, N.J.). 2021 Academic Article GET IT
Times cited: 5
Nonredundant functions of Mycobacterium tuberculosis chaperones promote survival under stress. Molecular microbiology. 2020 Academic Article GET IT
Times cited: 10
Immigration in science. The Journal of experimental medicine. 2020 Academic Article GET IT
Times cited: 1
Biology of antimicrobial resistance and approaches to combat it. Science translational medicine. 2020 Review GET IT
Times cited: 70
Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases. Frontiers in microbiology. 2020 Academic Article GET IT
Times cited: 15
Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB. PLoS pathogens. 2020 Academic Article GET IT
Times cited: 4
COVID-19 pandemic and health care disparities in head and neck cancer: Scanning the horizon. Head & neck. 2020 Academic Article GET IT
Times cited: 20
We are here for you and ready to hear from you. The Journal of experimental medicine. 2020 Academic Article GET IT
Resisting antimicrobial resistance. Nature reviews. Microbiology. 2020 Academic Article GET IT
Times cited: 86
Early Bactericidal Activity Trial of Nitazoxanide for Pulmonary Tuberculosis. Antimicrobial agents and chemotherapy. 2020 Academic Article GET IT
Times cited: 16
JEM goes viral. The Journal of experimental medicine. 2020 Editorial Article GET IT
Structural insights into phosphopantetheinyl hydrolase PptH from Mycobacterium tuberculosis. Protein science : a publication of the Protein Society. 2020 Academic Article GET IT
Times cited: 4
Correction to "Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis". ACS infectious diseases. 2019 Article GET IT
Selective Phenylimidazole-Based Inhibitors of the Mycobacterium tuberculosis Proteasome. Journal of medicinal chemistry. 2019 Academic Article GET IT
Times cited: 13
Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA. mBio. 2019 Academic Article GET IT
Times cited: 6
JEM Editorial Board: Expanding on the basis of cancer. The Journal of experimental medicine. 2019 Academic Article GET IT
Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis. ACS infectious diseases. 2019 Academic Article GET IT
Times cited: 8
Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis. ACS infectious diseases. 2019 Academic Article GET IT
Times cited: 8
Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition. Science (New York, N.Y.). 2019 Academic Article GET IT
Times cited: 46
Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis. ACS infectious diseases. 2018 Academic Article GET IT
Times cited: 19
Differentially Detectable Mycobacterium tuberculosis Cells in Sputum from Treatment-Naive Subjects in Haiti and Their Proportionate Increase after Initiation of Treatment. mBio. 2018 Academic Article GET IT
Times cited: 21
ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 51
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 51
Evidence for dispensability of protein kinase R in host control of tuberculosis. European journal of immunology. 2018 Academic Article GET IT
Times cited: 8
Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis. ACS infectious diseases. 2018 Academic Article GET IT
Times cited: 14
The new face of JEM. The Journal of experimental medicine. 2017 Academic Article GET IT
Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes. Nature communications. 2017 Academic Article GET IT
Times cited: 39
JEM Advisory Editorial Board: Increasing diversity. The Journal of experimental medicine. 2017 Academic Article GET IT
Times cited: 1
Kunkel Lecture: Fundamental immunodeficiency and its correction. The Journal of experimental medicine. 2017 Review GET IT
Times cited: 9
Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 48
A time of change. The Journal of experimental medicine. 2017 Editorial Article GET IT
Targeting Phenotypically Tolerant Mycobacterium tuberculosis. Microbiology spectrum. 2017 Review GET IT
Times cited: 81
Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome. Biochemistry. 2016 Academic Article GET IT
Times cited: 14
New Evidence for the Complexity of the Population Structure of Mycobacterium tuberculosis Increases the Diagnostic and Biologic Challenges. American journal of respiratory and critical care medicine. 2016 Comment GET IT
Times cited: 20
Visualization of the Charcoal Agar Resazurin Assay for Semi-quantitative, Medium-throughput Enumeration of Mycobacteria. Journal of visualized experiments : JoVE. 2016 Academic Article GET IT
Times cited: 8
Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 48
Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 32
Macrophages' Choice: Take It In or Keep It Out. Immunity. 2016 Comment GET IT
Times cited: 12
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS pathogens. 2016 Academic Article GET IT
Times cited: 192
N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 65
Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis. Journal of medicinal chemistry. 2016 Academic Article GET IT
Times cited: 37
Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase. Tuberculosis (Edinburgh, Scotland). 2015 Academic Article GET IT
Times cited: 4
E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 43
Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy. 2015 Academic Article GET IT
Times cited: 33
Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis. PloS one. 2015 Academic Article GET IT
Times cited: 15
Video podcast: Tuberculosis. Immunological reviews. 2015 Editorial Article GET IT
Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells. Cell host & microbe. 2015 Academic Article GET IT
Times cited: 70
A multi-stress model for high throughput screening against non-replicating Mycobacterium tuberculosis. Methods in molecular biology (Clifton, N.J.). 2015 Academic Article GET IT
Times cited: 46
Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis. ACS chemical biology. 2014 Academic Article GET IT
Times cited: 25
Antibiotic resistance--problems, progress, and prospects. The New England journal of medicine. 2014 Academic Article GET IT
Times cited: 317
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis. Nature communications. 2014 Academic Article GET IT
Times cited: 198
Synthetic calanolides with bactericidal activity against replicating and nonreplicating Mycobacterium tuberculosis. Journal of medicinal chemistry. 2014 Academic Article GET IT
Times cited: 71
Benzimidazole-based compounds kill Mycobacterium tuberculosis. European journal of medicinal chemistry. 2014 Academic Article GET IT
Times cited: 36
Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry. 2013 Academic Article GET IT
Times cited: 12
Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 66
Perspective: Graduation time. Nature. 2013 Academic Article GET IT
Times cited: 1
Nitrite impacts the survival of Mycobacterium tuberculosis in response to isoniazid and hydrogen peroxide. MicrobiologyOpen. 2013 Academic Article GET IT
Times cited: 21
Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis. PloS one. 2013 Academic Article GET IT
Times cited: 55
N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets. Journal of the American Chemical Society. 2013 Academic Article GET IT
Times cited: 44
Influence of allosteric regulators on individual steps in the reaction catalyzed by Mycobacterium tuberculosis 2-hydroxy-3-oxoadipate synthase. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 19
SARM is required for neuronal injury and cytokine production in response to central nervous system viral infection. Journal of immunology (Baltimore, Md. : 1950). 2013 Academic Article GET IT
Times cited: 40
Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nature reviews. Immunology. 2013 Review GET IT
Times cited: 999
Efficacy of nitazoxanide against clinical isolates of Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy. 2013 Academic Article GET IT
Times cited: 32
Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 89
Fresh approaches to anti-infective therapies. Science translational medicine. 2012 Review GET IT
Times cited: 128
Secretory products of macrophages: twenty-five years on. The Journal of clinical investigation. 2012 Academic Article GET IT
Times cited: 18
Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R. PloS one. 2012 Academic Article GET IT
Times cited: 35
Remembering Ralph Steinman. The Journal of experimental medicine. 2011 Academic Article GET IT
Times cited: 6
In vitro differentiation of human macrophages with enhanced antimycobacterial activity. The Journal of clinical investigation. 2011 Academic Article GET IT
Times cited: 77
Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice. Tuberculosis (Edinburgh, Scotland). 2011 Academic Article GET IT
Times cited: 6
Making space for anti-infective drug discovery. Cell host & microbe. 2011 Academic Article GET IT
Times cited: 18
Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorganic & medicinal chemistry letters. 2011 Academic Article GET IT
Times cited: 18
Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Trends in microbiology. 2011 Academic Article GET IT
Times cited: 126
Towards new business models for R&D for novel antibiotics. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy. 2011 Review GET IT
Times cited: 53
Identification of a chemical that inhibits the mycobacterial UvrABC complex in nucleotide excision repair. Biochemistry. 2011 Academic Article GET IT
Times cited: 27
Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. Cell host & microbe. 2011 Academic Article GET IT
Times cited: 96
Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis. ACS medicinal chemistry letters. 2011 Academic Article GET IT
Times cited: 91
Genome-wide screen for Mycobacterium tuberculosis genes that regulate host immunity. PloS one. 2010 Academic Article GET IT
Times cited: 113
Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates. Chemistry & biology. 2010 Academic Article GET IT
Times cited: 279
A protecting group-free synthesis of deazathiamine: a step toward inhibitor design. Bioorganic & medicinal chemistry letters. 2010 Academic Article GET IT
Times cited: 11
Induction of ER stress in macrophages of tuberculosis granulomas. PloS one. 2010 Academic Article GET IT
Times cited: 106
Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010 Academic Article GET IT
Times cited: 136
Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome. Archives of biochemistry and biophysics. 2010 Academic Article GET IT
Times cited: 50
Killing of non-replicating Mycobacterium tuberculosis by 8-hydroxyquinoline. The Journal of antimicrobial chemotherapy. 2010 Academic Article GET IT
Times cited: 66
Nonresolving inflammation. Cell. 2010 Review GET IT
Times cited: 1487
SnapShot: Reactive Oxygen Intermediates (ROI). Cell. 2010 Academic Article GET IT
Times cited: 173
N-iminoethyl-L-lysine improves memory and reduces amyloid pathology in a transgenic mouse model of amyloid deposition. Neurochemistry international. 2009 Academic Article GET IT
Times cited: 12
Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa. Structure (London, England : 1993). 2009 Academic Article GET IT
Times cited: 64
Inhibitors selective for mycobacterial versus human proteasomes. Nature. 2009 Academic Article GET IT
Times cited: 188
Acid resistance in Mycobacterium tuberculosis. Journal of bacteriology. 2009 Review GET IT
Times cited: 176
Taming tuberculosis: a challenge for science and society. Cell host & microbe. 2009 Academic Article GET IT
Times cited: 35
Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease. Journal of neurochemistry. 2009 Academic Article GET IT
Times cited: 95
Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite. Molecular microbiology. 2009 Academic Article GET IT
Times cited: 62
Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment. Journal of bacteriology. 2008 Academic Article GET IT
Times cited: 120
Identification of a copper-binding metallothionein in pathogenic mycobacteria. Nature chemical biology. 2008 Academic Article GET IT
Times cited: 163
A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis. Tuberculosis (Edinburgh, Scotland). 2008 Review GET IT
Times cited: 52
A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis. Nature medicine. 2008 Academic Article GET IT
Times cited: 257
Metchnikoff's Legacy in 2008. Nature immunology. 2008 Conference Paper GET IT
Times cited: 37
Selective killing of nonreplicating mycobacteria. Cell host & microbe. 2008 Academic Article GET IT
Times cited: 151
Epidemic inflammation: pondering obesity. Molecular medicine (Cambridge, Mass.). 2008 Review GET IT
Times cited: 108
New approaches to filling the gap in tuberculosis drug discovery. PLoS medicine. 2007 Academic Article GET IT
Times cited: 25
MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. The Journal of experimental medicine. 2007 Academic Article GET IT
Times cited: 158
Aligning pharmaceutical innovation with medical need. Nature medicine. 2007 Academic Article GET IT
Times cited: 42
Pulmonary nodules in an infliximab-treated rheumatoid arthritis patient: a clinical pathology conference held by the Division of Rheumatology at Hospital for Special Surgery. HSS journal : the musculoskeletal journal of Hospital for Special Surgery. 2007 Conference Paper GET IT
Times cited: 1379
Role of iNOS in human host defense. Science (New York, N.Y.). 2006 Letter GET IT
Times cited: 55
Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in vitro. Infection and immunity. 2006 Academic Article GET IT
Times cited: 14
Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity. Molecular microbiology. 2006 Academic Article GET IT
Times cited: 92
Neutrophils and immunity: challenges and opportunities. Nature reviews. Immunology. 2006 Review GET IT
Times cited: 2121
Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate. Molecular microbiology. 2006 Academic Article GET IT
Times cited: 111
Abrupt expression of TLR4 in TLR4-deficient macrophages imposes a selective disadvantage: genetic evidence for TLR4-dependent responses to endogenous, nonmicrobial stimuli. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 3
Outlook: the profit problem in antibiotic R&D. Nature reviews. Drug discovery. 2005 Review GET IT
Times cited: 44
Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase. The Journal of experimental medicine. 2005 Academic Article GET IT
Times cited: 173
Progress and new directions in genetics of tuberculosis: an NHLBI working group report. American journal of respiratory and critical care medicine. 2005 Academic Article GET IT
Times cited: 15
Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 28
Role for nucleotide excision repair in virulence of Mycobacterium tuberculosis. Infection and immunity. 2005 Academic Article GET IT
Times cited: 98
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. The Journal of experimental medicine. 2005 Academic Article GET IT
Times cited: 58
Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 160
A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP. Molecular microbiology. 2005 Academic Article GET IT
Times cited: 118
Characterization of a Mycobacterium tuberculosis proteasomal ATPase homologue. Molecular microbiology. 2005 Academic Article GET IT
Times cited: 112
Antibiotics at the crossroads. Nature. 2004 Academic Article GET IT
Times cited: 336
The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide. Science (New York, N.Y.). 2003 Academic Article GET IT
Times cited: 427
MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis. The Journal of experimental medicine. 2003 Academic Article GET IT
Times cited: 123
Immunology: Oxygen and the inflammatory cell. Nature. 2003 Article GET IT
Times cited: 71
Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling. The Journal of clinical investigation. 2003 Review GET IT
Times cited: 390
Critical role of the carboxyl terminus of proline-rich tyrosine kinase (Pyk2) in the activation of human neutrophils by tumor necrosis factor: separation of signals for the respiratory burst and degranulation. The Journal of experimental medicine. 2003 Academic Article GET IT
Times cited: 48
Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell. 2002 Academic Article GET IT
Times cited: 529
Immunology. Catalytic antibody bridges innate and adaptive immunity. Science (New York, N.Y.). 2002 Comment GET IT
Times cited: 32
Inducible nitric oxide synthase in the tuberculous human lung. American journal of respiratory and critical care medicine. 2002 Editorial Article GET IT
Times cited: 46
Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science (New York, N.Y.). 2002 Academic Article GET IT
Times cited: 329
Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function. Archives of biochemistry and biophysics. 2002 Review GET IT
Times cited: 262
Pott's puffy tumor and epidural abscess arising from dental sepsis: a case report. 2001 GET IT
Times cited: 40
Lung surfactant and reactive oxygen-nitrogen species: antimicrobial activity and host-pathogen interactions. American journal of physiology. Lung cellular and molecular physiology. 2001 Review GET IT
Times cited: 63
Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates. Proceedings of the National Academy of Sciences of the United States of America. 2001 Academic Article GET IT
Times cited: 179
A diagnostic and therapeutic approach to paragangliomas of the larynx. 2001 GET IT
Times cited: 40
Peroxynitrite reductase activity of bacterial peroxiredoxins. Nature. 2000 Academic Article GET IT
Times cited: 572
Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proceedings of the National Academy of Sciences of the United States of America. 2000 Review GET IT
Times cited: 1165
Antisense RNA to eIF4E suppresses oncogenic properties of a head and neck squamous cell carcinoma cell line. The Laryngoscope. 2000 Academic Article GET IT
Times cited: 83
Elevation of IL-18 in human sepsis. Journal of clinical immunology. 2000 Academic Article GET IT
Times cited: 80
Reduced F-18 fluorodeoxyglucose uptake within marrow after external beam radiation. 2000 GET IT
Times cited: 18
Reactive nitrogen intermediates and the pathogenesis of Salmonella and mycobacteria. Current opinion in microbiology. 2000 Review GET IT
Times cited: 137
Leiomyoma of the trachea: a case report and a novel surgical approach. 2000 GET IT
Times cited: 7
Echocardiographic and survival studies in mice undergoing endotoxic shock: effects of genetic ablation of inducible nitric oxide synthase and pharmacologic antagonism of platelet-activating factor. The Journal of surgical research. 1999 Academic Article GET IT
Times cited: 15
Peptidomimetic fluoromethylketone rescues mice from lethal endotoxic shock. Molecular medicine (Cambridge, Mass.). 1999 Academic Article GET IT
Times cited: 37
Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF. The Journal of clinical investigation. 1999 Academic Article GET IT
Times cited: 114
noxR3, a novel gene from Mycobacterium tuberculosis, protects Salmonella typhimurium from nitrosative and oxidative stress. Infection and immunity. 1999 Academic Article GET IT
Times cited: 53
Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide. Proceedings of the National Academy of Sciences of the United States of America. 1999 Academic Article GET IT
Times cited: 176
Lethality of endotoxin in mice genetically deficient in the respiratory burst oxidase, inducible nitric oxide synthase, or both. Shock (Augusta, Ga.). 1999 Academic Article GET IT
Times cited: 39
Progressive amplification and overexpression of the eukaryotic initiation factor 4E gene in different zones of head and neck cancers. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 1999 Academic Article GET IT
Times cited: 38
Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani. The Journal of experimental medicine. 1999 Academic Article GET IT
Times cited: 361
A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity. Cancer research. 1999 Academic Article GET IT
Times cited: 284
Competitive PCR to detect eIF4E gene amplification in head and neck cancer. Head & neck. 1999 Academic Article GET IT
Times cited: 29
Identification of genes involved in innate responsiveness to bacterial products by differential display. Methods (San Diego, Calif.). 1998 Academic Article GET IT
Times cited: 4
Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice. The Journal of experimental medicine. 1998 Academic Article GET IT
Times cited: 163
Utility of serial rectal swab cultures for detection of ceftazidime- and imipenem-resistant gram-negative bacilli from patients in the intensive care unit. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 1998 Academic Article GET IT
Times cited: 7
Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection. Journal of virology. 1998 Academic Article GET IT
Times cited: 57
Effects of postoperative external beam irradiation after carotid artery stripping of nodal metastasis. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 1998 Academic Article GET IT
Times cited: 2
[Non-obstructive azoospermia and ICSI]. Contraception, fertilite, sexualite (1992). 1998 Academic Article GET IT
Alkyl hydroperoxide reductase subunit C (AhpC) protects bacterial and human cells against reactive nitrogen intermediates. Molecular cell. 1998 Academic Article GET IT
Times cited: 172
Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. The Journal of experimental medicine. 1998 Academic Article GET IT
Times cited: 427
Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. Cancer research. 1998 Academic Article GET IT
Times cited: 319
Immune response during HIV and tuberculosis co-infection. Memorias do Instituto Oswaldo Cruz. 1998 Academic Article GET IT
Times cited: 6
Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. 1997 Academic Article GET IT
Times cited: 318
A novel antioxidant gene from Mycobacterium tuberculosis. The Journal of experimental medicine. 1997 Academic Article GET IT
Times cited: 91
Inducible nitric oxide synthase: what difference does it make?. The Journal of clinical investigation. 1997 Review GET IT
Times cited: 846
Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1997 Academic Article GET IT
Times cited: 251
Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas. Oncogene. 1997 Academic Article GET IT
Times cited: 121
Detection of the proto-oncogene eIF4E in surgical margins may predict recurrence in head and neck cancer. Oncogene. 1997 Academic Article GET IT
Times cited: 163
Identification of nitric oxide synthase as a protective locus against tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 1997 Academic Article GET IT
Times cited: 914
Bacterial infection induces nitric oxide synthase in human neutrophils. The Journal of clinical investigation. 1997 Academic Article GET IT
Times cited: 249
The Columbia-Cornell Alliance: a strategic response to a changing health care environment. JAMA. 1996 Academic Article GET IT
Times cited: 4
Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease. The Journal of experimental medicine. 1996 Academic Article GET IT
Times cited: 264
Inducible nitric oxide synthase requires both the canonical calmodulin-binding domain and additional sequences in order to bind calmodulin and produce nitric oxide in the absence of free Ca2+. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 90
Ceramide selectively inhibits early events in the response of human neutrophils to tumor necrosis factor. Journal of leukocyte biology. 1996 Academic Article GET IT
Times cited: 18
Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin. Proceedings of the National Academy of Sciences of the United States of America. 1995 Academic Article GET IT
Times cited: 71
Natural resistance and nitric oxide. Cell. 1995 Review GET IT
Times cited: 152
Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha. The Journal of clinical investigation. 1995 Academic Article GET IT
Times cited: 197
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell. 1995 Academic Article GET IT
Times cited: 1291
Vesicle membrane association of nitric oxide synthase in primary mouse macrophages. Journal of immunology (Baltimore, Md. : 1950). 1995 Academic Article GET IT
Times cited: 119
Inducible nitric oxide synthase: regulation subserves function. Current topics in microbiology and immunology. 1995 Review GET IT
Times cited: 23
Beta 2 integrin-dependent tyrosine phosphorylation of paxillin in human neutrophils treated with tumor necrosis factor. The Journal of cell biology. 1994 Academic Article GET IT
Times cited: 104
Carboxyl terminus of inducible nitric oxide synthase. Contribution to NADPH binding and enzymatic activity. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 76
The high-output nitric oxide pathway: role and regulation. Journal of leukocyte biology. 1994 Academic Article GET IT
Times cited: 475
Cytokine regulation of nitric oxide synthase in mouse retinal pigment epithelial cells in culture. Experimental eye research. 1994 Academic Article GET IT
Times cited: 38
Regulation of biosynthesis of nitric oxide. The Journal of biological chemistry. 1994 Review GET IT
Times cited: 1557
Nitric oxide and biopterin: a study in Chiaroscuro. The Journal of clinical investigation. 1994 Editorial Article GET IT
Times cited: 12
Macrophage activation revisited. Immunology today. 1994 Conference Paper GET IT
Times cited: 140
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 2076
Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages. Journal of leukocyte biology. 1994 Academic Article GET IT
Times cited: 211
Hemorrhagic tumor necrosis during a pilot trial of tumor necrosis factor-alpha and anti-GD3 ganglioside monoclonal antibody in patients with metastatic melanoma. Blood. 1994 Academic Article GET IT
Times cited: 49
Nitrite production by stimulated human polymorphonuclear leukocytes supplemented with azide and catalase. Biochemical and biophysical research communications. 1993 Academic Article GET IT
Times cited: 36
Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science (New York, N.Y.). 1993 Academic Article GET IT
Times cited: 759
Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats. FEBS letters. 1993 Academic Article GET IT
Times cited: 132
Suppression of arthritis by an inhibitor of nitric oxide synthase. The Journal of experimental medicine. 1993 Academic Article GET IT
Times cited: 599
Albumin inhibits neutrophil spreading and hydrogen peroxide release by blocking the shedding of CD43 (sialophorin, leukosialin). The Journal of cell biology. 1993 Academic Article GET IT
Times cited: 115
Traces of bacterial lipopolysaccharide suppress IFN-gamma-induced nitric oxide synthase gene expression in primary mouse macrophages. Journal of immunology (Baltimore, Md. : 1950). 1993 Academic Article GET IT
Times cited: 63
Modulation of macrophage function by transforming growth factor beta, interleukin-4, and interleukin-10. Annals of the New York Academy of Sciences. 1993 Review GET IT
Times cited: 391
Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor. The Journal of cell biology. 1993 Academic Article GET IT
Times cited: 139
Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-gamma and bacterial lipopolysaccharide. Transactions of the Association of American Physicians. 1993 Academic Article GET IT
Times cited: 39
Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10. The Journal of biological chemistry. 1992 Academic Article GET IT
Times cited: 499
Role of nitric oxide in antagonistic effects of transforming growth factor-beta and interleukin-1 beta on the beating rate of cultured cardiac myocytes. Molecular endocrinology (Baltimore, Md.). 1992 Academic Article GET IT
Times cited: 158
Nitric oxide as a secretory product of mammalian cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1992 Review GET IT
Times cited: 4166
Mobilizable intracellular pool of p55 (type I) tumor necrosis factor receptors in human neutrophils. Journal of leukocyte biology. 1992 Academic Article GET IT
Times cited: 33
Interactions of bacterial lipopolysaccharide with microtubule proteins. Journal of immunology (Baltimore, Md. : 1950). 1992 Academic Article GET IT
Times cited: 53
Treatment of patients with chronic granulomatous disease with recombinant human interferon-gamma does not improve neutrophil oxidative metabolism, cytochrome b558 content or levels of four anti-microbial proteins. Clinical and experimental immunology. 1992 Academic Article GET IT
Times cited: 38
Macrophage deactivation by interleukin 10. The Journal of experimental medicine. 1991 Academic Article GET IT
Times cited: 1141
Human neutrophil elastase releases a ligand-binding fragment from the 75-kDa tumor necrosis factor (TNF) receptor. Comparison with the proteolytic activity responsible for shedding of TNF receptors from stimulated neutrophils. The Journal of biological chemistry. 1991 Academic Article GET IT
Times cited: 190
Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide. The Journal of experimental medicine. 1991 Academic Article GET IT
Times cited: 405
A commentary: inducible nitric oxide synthase. Research in immunology. 1991 Academic Article GET IT
Times cited: 4
Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1991 Review GET IT
Times cited: 475
Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein. Proceedings of the National Academy of Sciences of the United States of America. 1991 Academic Article GET IT
Times cited: 733
Complementary DNA sequence of human neutrophil azurocidin, an antibiotic with extensive homology to serine proteases. Biochemical and biophysical research communications. 1991 Academic Article GET IT
Times cited: 44
Cytokines in context. The Journal of cell biology. 1991 Review GET IT
Times cited: 707
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine. The Journal of biological chemistry. 1991 Academic Article GET IT
Times cited: 500
Mechanisms and modulation of macrophage activation. Behring Institute Mitteilungen. 1991 Review GET IT
Times cited: 50
Production of large amounts of hydrogen peroxide by human tumor cells. Cancer research. 1991 Academic Article GET IT
Times cited: 2262
Role of nitric oxide synthesis in macrophage antimicrobial activity. Current opinion in immunology. 1991 Review GET IT
Times cited: 1330
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1991 Academic Article GET IT
Times cited: 412
The mode of action and clinical pharmacology of gliclazide: a review. Diabetes research and clinical practice. 1991 Review GET IT
Times cited: 115
Workshop summary: negative regulation of macrophage effector function. Annals of the New York Academy of Sciences. 1991 Academic Article GET IT
Times cited: 1
L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 212
Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma. Journal of immunology (Baltimore, Md. : 1950). 1990 Academic Article GET IT
Times cited: 460
FAD and GSH participate in macrophage synthesis of nitric oxide. Biochemical and biophysical research communications. 1990 Academic Article GET IT
Times cited: 155
Shared actions of endotoxin and taxol on TNF receptors and TNF release. Science (New York, N.Y.). 1990 Academic Article GET IT
Times cited: 285
Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties. The Journal of clinical investigation. 1990 Academic Article GET IT
Times cited: 161
Downregulation of tumor necrosis factor receptors on macrophages and endothelial cells by microtubule depolymerizing agents. The Journal of experimental medicine. 1990 Academic Article GET IT
Times cited: 110
On the role of 5-hydroxytryptamine in the peripheral action of fenfluramine: studies with the isolated rat soleus muscle. Biochemical pharmacology. 1990 Academic Article GET IT
Times cited: 6
Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. The Journal of biological chemistry. 1989 Academic Article GET IT
Times cited: 514
Transfusion-associated acute Chagas disease acquired in the United States. 1989 GET IT
Times cited: 181
Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins. The Journal of cell biology. 1989 Academic Article GET IT
Times cited: 470
Failure of fenfluramine to affect basal and insulin-stimulated hexose transport in rat skeletal muscle. Biochemical pharmacology. 1989 Academic Article GET IT
Times cited: 4
Adenosine regulates the respiratory burst of cytokine-triggered human neutrophils adherent to biologic surfaces. Journal of immunology (Baltimore, Md. : 1950). 1989 Academic Article GET IT
Times cited: 48
Antibiotic proteins of human polymorphonuclear leukocytes. Proceedings of the National Academy of Sciences of the United States of America. 1989 Academic Article GET IT
Times cited: 213
Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: requirement for inducible and constitutive components. Biochemical and biophysical research communications. 1989 Academic Article GET IT
Times cited: 117
Comparison of transforming growth factor-beta and a macrophage- deactivating polypeptide from tumor cells. Differences in antigenicity and mechanism of action. Journal of immunology (Baltimore, Md. : 1950). 1989 Academic Article GET IT
Times cited: 31
Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. The Journal of experimental medicine. 1989 Academic Article GET IT
Times cited: 1602
Macrophages rapidly internalize their tumor necrosis factor receptors in response to bacterial lipopolysaccharide. The Journal of biological chemistry. 1989 Academic Article GET IT
Times cited: 96
Fenfluramine studies. Science (New York, N.Y.). 1989 Letter GET IT
Times cited: 14
Ethical and legal aspects to death: the burial. Medicine and law. 1989 Academic Article GET IT
Times cited: 2
Introduction to Congress and the International Centre of Medicine and Law. Medicine and law. 1989 Academic Article GET IT
Patients' rights in a Third World southern African country, with special reference to Bophuthatswana: is there any potential for privatisation?. Medicine and law. 1989 Academic Article GET IT
Respiratory burst in adherent human neutrophils: triggering by colony-stimulating factors CSF-GM and CSF-G. Blood. 1989 Academic Article GET IT
Times cited: 222
In vivo killing of intracellular visceral Leishmania donovani by a macrophage-targeted hydrogen peroxide-generating system. The Journal of infectious diseases. 1988 Academic Article GET IT
Times cited: 10
The measurement of cytochrome b559 in polymorphonuclear leukocytes and macrophages in the presence of hemoglobin or mitochondrial cytochromes. Analytical biochemistry. 1988 Academic Article GET IT
Times cited: 12
Identification of arginine as a precursor of endothelium-derived relaxing factor. Proceedings of the National Academy of Sciences of the United States of America. 1988 Academic Article GET IT
Times cited: 381
Agonist and antagonist effects of interferon alpha and beta on activation of human macrophages. Two classes of interferon gamma receptors and blockade of the high-affinity sites by interferon alpha or beta. The Journal of experimental medicine. 1988 Academic Article GET IT
Times cited: 62
Analysis of the nonfunctional respiratory burst in murine Kupffer cells. The Journal of experimental medicine. 1988 Academic Article GET IT
Times cited: 24
Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. The Journal of experimental medicine. 1988 Academic Article GET IT
Times cited: 466
Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes. The Journal of clinical investigation. 1987 Academic Article GET IT
Times cited: 684
Recombinant granulocyte/macrophage colony-stimulating factor activates macrophages to inhibit Trypanosoma cruzi and release hydrogen peroxide. Comparison with interferon gamma. The Journal of experimental medicine. 1987 Academic Article GET IT
Times cited: 185
In vitro susceptibility of nosocomial Pseudomonas aeruginosa, enterobacteriaceae, and staphylococci to ciprofloxacin and ten other broad-spectrum antibiotics. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. 1987 Academic Article GET IT
Times cited: 1
Cellular responses to the intradermal injection of recombinant human gamma-interferon in lepromatous leprosy patients. The American journal of pathology. 1987 Academic Article GET IT
Times cited: 59
Hydrogen peroxide release by alveolar macrophages from sarcoid patients and by alveolar macrophages from normals after exposure to recombinant interferons alpha A, beta, and gamma and 1,25-dihydroxyvitamin D3. The Journal of clinical investigation. 1987 Academic Article GET IT
Times cited: 60
Experimental visceral leishmaniasis: production of interleukin 2 and interferon-gamma, tissue immune reaction, and response to treatment with interleukin 2 and interferon-gamma. Journal of immunology (Baltimore, Md. : 1950). 1987 Academic Article GET IT
Times cited: 156
Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac-1 (complement receptor type 3). The Journal of experimental medicine. 1987 Academic Article GET IT
Times cited: 38
Secretion of pyruvate. An antioxidant defense of mammalian cells. The Journal of experimental medicine. 1987 Academic Article GET IT
Times cited: 251
Secretory products of macrophages. The Journal of clinical investigation. 1987 Review GET IT
Times cited: 2175
Pharmacological treatments that affect CNS activity: serotonin. Annals of the New York Academy of Sciences. 1987 Review GET IT
Times cited: 28
Subcellular location and properties of bactericidal factors from human neutrophils. The Journal of experimental medicine. 1986 Academic Article GET IT
Times cited: 37
Macrophage deactivation. Altered kinetic properties of superoxide-producing enzyme after exposure to tumor cell-conditioned medium. The Journal of experimental medicine. 1986 Academic Article GET IT
Times cited: 30
Release of arachidonate and reduction of oxygen. Independent metabolic bursts of the mouse peritoneal macrophage. The Journal of biological chemistry. 1986 Academic Article GET IT
Times cited: 41
Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein. Proceedings of the National Academy of Sciences of the United States of America. 1986 Academic Article GET IT
Times cited: 20
Effect of recombinant interferon-gamma on hydrogen peroxide-releasing capacity of monocyte-derived macrophages from patients with lepromatous leprosy. Journal of immunology (Baltimore, Md. : 1950). 1986 Academic Article GET IT
Times cited: 25
Local and systemic effects of intradermal recombinant interferon-gamma in patients with lepromatous leprosy. The New England journal of medicine. 1986 Academic Article GET IT
Times cited: 259
Phase I trial of recombinant interferon gamma by 1-hour i.v. infusion. Cancer treatment reports. 1986 Academic Article GET IT
Times cited: 37
Phase I trial of recombinant interferon gamma in cancer patients. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1986 Academic Article GET IT
Times cited: 105
Functional channel formation associated with cytotoxic T-cell granules. Proceedings of the National Academy of Sciences of the United States of America. 1986 Academic Article GET IT
Times cited: 72
Macrophage activation: some questions. Annales de l'Institut Pasteur. Immunologie. 1986 Academic Article GET IT
Times cited: 14
Peroxide and pteridine: a hypothesis on the regulation of macrophage antimicrobial activity by interferon gamma. Interferon. 1986 Review GET IT
Times cited: 106
Secretion of toxic oxygen products by macrophages: regulatory cytokines and their effects on the oxidase. Ciba Foundation symposium. 1986 Review GET IT
Times cited: 66
Administration of recombinant interferon gamma to cancer patients enhances monocyte secretion of hydrogen peroxide. Proceedings of the National Academy of Sciences of the United States of America. 1985 Academic Article GET IT
Times cited: 89
Hydrogen peroxide from cellular metabolism of cystine. A requirement for lysis of murine tumor cells by vernolepin, a glutathione-depleting antineoplastic. The Journal of clinical investigation. 1985 Academic Article GET IT
Times cited: 22
Resistance of human tumor cells in vitro to oxidative cytolysis. The Journal of clinical investigation. 1985 Academic Article GET IT
Times cited: 66
Liver macrophages in murine listeriosis. Cell-mediated immunity is correlated with an influx of macrophages capable of generating reactive oxygen intermediates. The Journal of experimental medicine. 1985 Academic Article GET IT
Times cited: 81
Murine Kupffer cells. Mononuclear phagocytes deficient in the generation of reactive oxygen intermediates. The Journal of experimental medicine. 1985 Academic Article GET IT
Times cited: 112
A semi-automated micro-assay for H2O2 release by human blood monocytes and mouse peritoneal macrophages. Journal of immunological methods. 1985 Academic Article GET IT
Times cited: 137
Salivary progesterone profile after in-vitro fertilisation/embryo transfer. Lancet (London, England). 1985 Letter GET IT
Times cited: 2
Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma. Journal of immunology (Baltimore, Md. : 1950). 1985 Academic Article GET IT
Times cited: 257
Relationship between extracellular stimulation of intracellular killing and oxygen-dependent microbicidal systems of monocytes. Infection and immunity. 1985 Academic Article GET IT
Times cited: 14
Biological activities of a human pluripotent hemopoietic colony-stimulating factor. Haematology and blood transfusion. 1985 Academic Article GET IT
Times cited: 4
[Antenatal diagnosis and fetal surgery]. La Revue du praticien. 1984 Academic Article GET IT
Epidemiology of endemic Pseudomonas aeruginosa: why infection control efforts have failed. The Journal of infectious diseases. 1984 Academic Article GET IT
Times cited: 122
Association of infection caused by Pseudomonas aeruginosa serotype O11 with intravenous abuse of pentazocine mixed with tripelennamine. Journal of clinical microbiology. 1984 Academic Article GET IT
Times cited: 20
Glutathione metabolism as a determinant of therapeutic efficacy: a review. Cancer research. 1984 Review GET IT
Times cited: 503
Activation of human macrophages. Comparison of other cytokines with interferon-gamma. The Journal of experimental medicine. 1984 Academic Article GET IT
Times cited: 291
Bacillus Calmette-Guérin-activated murine macrophages kill syngeneic melanoma cells under strict anaerobic conditions. The Journal of experimental medicine. 1984 Academic Article GET IT
Times cited: 13
Enzymatic basis of macrophage activation. Kinetic analysis of superoxide production in lysates of resident and activated mouse peritoneal macrophages and granulocytes. The Journal of biological chemistry. 1984 Academic Article GET IT
Times cited: 100
Pseudomonas in the sinks in an intensive care unit: relation to patients. Journal of clinical pathology. 1984 Academic Article GET IT
Times cited: 62
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. The Journal of experimental medicine. 1983 Academic Article GET IT
Times cited: 1408
Suppression of macrophage antimicrobial activity by a tumor cell product. Journal of immunology (Baltimore, Md. : 1950). 1983 Academic Article GET IT
Times cited: 21
Molecular mechanisms in tumor-cell killing by activated macrophages. Immunology today. 1983 Academic Article GET IT
Times cited: 114
Inhibition of glutathione synthesis augments lysis of murine tumor cells by sulfhydryl-reactive antineoplastics. The Journal of clinical investigation. 1983 Academic Article GET IT
Times cited: 57
A simple method for counting adherent cells: application to cultured human monocytes, macrophages and multinucleated giant cells. Journal of immunological methods. 1983 Academic Article GET IT
Times cited: 131
Mechanisms of macrophage antimicrobial activity. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1983 Review GET IT
Times cited: 97
Lymphokines enhance the capacity of human monocytes to secret reactive oxygen intermediates. The Journal of clinical investigation. 1982 Academic Article GET IT
Times cited: 65
Role of oxygen in T cell-mediated cytolysis. Journal of immunology (Baltimore, Md. : 1950). 1982 Academic Article GET IT
Times cited: 24
Suppression of macrophage oxidative metabolism by products of malignant and nonmalignant cells. The Journal of experimental medicine. 1982 Academic Article GET IT
Times cited: 53
Augmentation of spontaneous macrophage-mediated cytolysis by eosinophil peroxidase. The Journal of experimental medicine. 1982 Academic Article GET IT
Times cited: 47
Structural and phenotypic varieties of gentamicin resistance plasmids in hospital strains of Staphylococcus aureus and coagulase-negative staphylococci. Antimicrobial agents and chemotherapy. 1982 Academic Article GET IT
Times cited: 38
Secretion of oxygen intermediates: role in effector functions of activated macrophages. Federation proceedings. 1982 Academic Article GET IT
Times cited: 134
Gentamicin-resistant staphylococci as hospital flora: epidemiology and resistance plasmids. The Journal of infectious diseases. 1982 Academic Article GET IT
Times cited: 23
Glutathione depletion sensitizes tumor cells to oxidative cytolysis. The Journal of biological chemistry. 1982 Academic Article GET IT
Times cited: 183
Antitumor effects of hydrogen peroxide in vivo. The Journal of experimental medicine. 1981 Academic Article GET IT
Times cited: 108
Hydrogen peroxide and cytolytic factor can interact synergistically in effecting cytolysis of neoplastic targets. Journal of immunology (Baltimore, Md. : 1950). 1981 Academic Article GET IT
Times cited: 31
Hydrogen peroxide metabolism in human monocytes during differentiation in vitro. The Journal of clinical investigation. 1981 Academic Article GET IT
Times cited: 274
Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysis. The Journal of experimental medicine. 1981 Academic Article GET IT
Times cited: 175
Macrophage oxygen-dependent antimicrobial activity. IV. Role of endogenous scavengers of oxygen intermediates. The Journal of experimental medicine. 1980 Academic Article GET IT
Times cited: 47
The macrophage as an effector cell. The New England journal of medicine. 1980 Academic Article GET IT
Times cited: 417
Role of activated macrophages in antibody-dependent lysis of tumor cells. The Journal of experimental medicine. 1980 Academic Article GET IT
Times cited: 67
Role of oxygen-dependent mechanisms in antibody-induced lysis of tumor cells by activated macrophages. The Journal of experimental medicine. 1980 Academic Article GET IT
Times cited: 130
Identity and interspecific transfer of gentamicin-resistance plasmids in Staphylococcus aureus and Staphylococcus epidermidis. The Journal of infectious diseases. 1980 Academic Article GET IT
Times cited: 56
Endemic aminoglycoside resistance in gram-negative bacilli: epidemiology and mechanisms. The Journal of infectious diseases. 1980 Academic Article GET IT
Times cited: 73
Macrophage oxygen-dependent antimicrobial activity. II. The role of oxygen intermediates. The Journal of experimental medicine. 1979 Academic Article GET IT
Times cited: 137
Activation of macrophages in vivo and in vitro. Correlation between hydrogen peroxide release and killing of Trypanosoma cruzi. The Journal of experimental medicine. 1979 Academic Article GET IT
Times cited: 209
Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide. The Journal of experimental medicine. 1979 Academic Article GET IT
Times cited: 298
Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity. The Journal of experimental medicine. 1979 Academic Article GET IT
Times cited: 359
In vitro activity of Sch 21420, derivative of gentamicin B, compared to that of amikacin. Antimicrobial agents and chemotherapy. 1978 Academic Article GET IT
Times cited: 10
In vitro activity of 5-episisomicin in bacteria resistant to other aminoglycoside antibiotics. Antimicrobial agents and chemotherapy. 1978 Academic Article GET IT
Times cited: 5
Infections due to gentamicin-resistant Staphylococcus aureus strain in a nursery for neonatal infants. Antimicrobial agents and chemotherapy. 1978 Academic Article GET IT
Times cited: 20
Hydrogen peroxide release from mouse peritoneal macrophages: dependence on sequential activation and triggering. The Journal of experimental medicine. 1977 Academic Article GET IT
Times cited: 336
Characterization of the nonphagocytic adherent cell from the peritoneal cavity of normal and BCG-treated mice. Journal of immunology (Baltimore, Md. : 1950). 1977 Review GET IT
Times cited: 49
Decreased phagocytosis by peritoneal macrophages from BCG-treated mice: induction of the phagocytic defect in normal macrophages with BCG in vitro. Cellular immunology. 1977 Academic Article GET IT
Times cited: 32
In vitro comparison of netilmicin, a semisynthetic derivative of sisomicin, and four other aminoglycoside antibiotics. Antimicrobial agents and chemotherapy. 1976 Academic Article GET IT
Times cited: 55
Isolation of a subpopulation of adherent peritoneal cells with anti-tumour activity. Nature. 1976 Academic Article GET IT
Times cited: 30
Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages. The Journal of experimental medicine. 1975 Academic Article GET IT
Times cited: 59
Cryptococcal osteomyelitis treated with 5-fluorocytosine. The American review of respiratory disease. 1974 Academic Article GET IT
Times cited: 18
Gentamicin-adenylyltransferase activity as a cause of gentamicin resistance in clinical isolates of Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy. 1974 Academic Article GET IT
Times cited: 9
Characterization of a lymphocyte factor which alters macrophage functions. The Journal of experimental medicine. 1973 Academic Article GET IT
Times cited: 145
Physicochemical characteristics of several mediators from stimulated guinea pig and human lymphocytes. Transplantation proceedings. 1972 Academic Article GET IT
Times cited: 2
Alterations of macrophage functions by mediators from lymphocytes. The Journal of experimental medicine. 1971 Academic Article GET IT
Times cited: 330
[Lipo-mobilizing factor of pituitary origin]. Pathologie-biologie. 1970 Academic Article GET IT
The use of alcian blue in vivo. I. Physiologic considerations. Histochemie. Histochemistry. Histochimie. 1967 Academic Article GET IT
Times cited: 6

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Funding awarded

Mechanisms of macrophage death co-dependent on M. tuberculosis and IFN-a,b receptor awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2023 - 2025
Phosphopantetheinyl transferase (PptT) inhibitors for treatment of TB- INV-040480 awarded by Bill & Melinda Gates Foundation Principal Investigator 2022 - 2024
Novel inhibitors of phosphopantetheine transferase (PptT) from M. tuberculosis awarded by TB Alliance Principal Investigator 2023 - 2023
Host-directed therapy of tuberculosis: Rescuing macrophages and enhancing their activation awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2018 - 2023

Research Training in Infectious Diseases awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2020 - 2025
Screening NadE and NadD awarded by Bill & Melinda Gates Foundation Co-Investigator 2022 - 2023

Tri-Institutional Tuberculosis Research Advancement Center awarded by National Institute of Allergy & Infectious Diseases Key Personnel 2022 - 2027
Transmission Aerobiology of M. tuberculosis: Genes and Metabolic Pathways That Sustain Mtb Across an Evolutionary Bottleneck awarded by National Institute of Allergy & Infectious Diseases Key Personnel 2021 - 2026

Discovery of Phosphopantetheinyl Transferase Inhibitors Against Mycobacterium tuberculosis awarded by Chan Zuckerberg Initiative Principal Investigator Subaward 2021 - 2025

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Background

education and training

M.D., Harvard Medical School 1972
B.A., Harvard University 1967

Contact

full name

Carl F. Nathan

primary email

cnathan@med.cornell.edu

VIVO Weill Cornell Medical College

Carl F. Nathan Chair of Microbiology and Immunology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email