Soluble CD8 attenuates cytotoxic T cell responses against replication-defective adenovirus affording transprotection of transgenes in vivo. Academic Article uri icon

Overview

abstract

  • The T cell coreceptor, CD8, enhances T cell-APC interactions. Because soluble CD8alpha homodimers can antagonize CD8 T cell activation in vitro, we asked whether secretion of soluble CD8 would effect cytotoxic T cell responses in vivo. Production of soluble CD8 by a replication-defective adenovirus vector allowed persistent virus expression for up to 5 mo in C57BL/6 mice and protected a second foreign transgene from rapid deletion. Soluble CD8 selectively inhibited CD8 T cell proliferation and IFN-gamma production and could also attenuate peptide-specific CD8 T cell responses in vivo. These finding suggest that gene vector delivery of soluble CD8 may have therapeutic applications.

publication date

  • August 1, 2000

Research

keywords

  • Adenoviridae
  • CD8 Antigens
  • Defective Viruses
  • Gene Expression Regulation
  • T-Lymphocytes, Cytotoxic
  • Transgenes

Identity

Scopus Document Identifier

  • 0034254715

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.165.3.1470

PubMed ID

  • 10903752

Additional Document Info

volume

  • 165

issue

  • 3