Falck-Pedersen, Erik

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E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 7
ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1). The Journal of biological chemistry. 2020 Academic Article GET IT
Times cited: 10
Parvovirus B19 integration into human CD36+ erythroid progenitor cells. Virology. 2017 Academic Article GET IT
Times cited: 14
The C Terminus of the Herpes Simplex Virus UL25 Protein Is Required for Release of Viral Genomes from Capsids Bound to Nuclear Pores. Journal of virology. 2017 Academic Article GET IT
Times cited: 26
Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity. Journal of virology. 2016 Academic Article GET IT
Times cited: 41
Unabated adenovirus replication following activation of the cGAS/STING-dependent antiviral response in human cells. Journal of virology. 2014 Academic Article GET IT
Times cited: 28
Adeno-associated virus type 2 preferentially integrates single genome copies with defined breakpoints. Virology journal. 2014 Academic Article GET IT
Times cited: 5
Highly divergent integration profile of adeno-associated virus serotype 5 revealed by high-throughput sequencing. Journal of virology. 2013 Academic Article GET IT
Times cited: 9
Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade. Journal of virology. 2013 Academic Article GET IT
Times cited: 166
High-throughput sequencing reveals principles of adeno-associated virus serotype 2 integration. Journal of virology. 2013 Academic Article GET IT
Times cited: 30
Cell-specific regulation of nucleic acid sensor cascades: a controlling interest in the antiviral response. Journal of virology. 2012 Academic Article GET IT
Times cited: 16
Sensing adenovirus infection: activation of interferon regulatory factor 3 in RAW 264.7 cells. Journal of virology. 2012 Academic Article GET IT
Times cited: 49
Serotype 5 Adenovirus fiber (F7F41S) chimeric vectors incur packaging deficiencies when targeting peptides are inserted into Ad41 short fiber. Virology. 2009 Academic Article GET IT
Times cited: 1
Clathrin adaptor AP1B controls adenovirus infectivity of epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 58
Adenovirus induction of IRF3 occurs through a binary trigger targeting Jun N-terminal kinase and TBK1 kinase cascades and type I interferon autocrine signaling. Journal of virology. 2009 Academic Article GET IT
Times cited: 36
Adeno-associated virus type 2 p5 promoter: a rep-regulated DNA switch element functioning in transcription, replication, and site-specific integration. Journal of virology. 2007 Academic Article GET IT
Times cited: 11
Sensing infection by adenovirus: Toll-like receptor-independent viral DNA recognition signals activation of the interferon regulatory factor 3 master regulator. Journal of virology. 2007 Academic Article GET IT
Times cited: 134
Adenovirus capsid chimeras: fiber terminal exon insertions/gene replacements in the major late transcription unit. Methods in molecular medicine. 2007 Academic Article GET IT
Times cited: 3
Fiber and penton base capsid modifications yield diminished adenovirus type 5 transduction and proinflammatory gene expression with retention of antigen-specific humoral immunity. Journal of virology. 2006 Academic Article GET IT
Times cited: 26
Influence of fiber detargeting on adenovirus-mediated innate and adaptive immune activation. Journal of virology. 2005 Academic Article GET IT
Times cited: 35
Adeno-associated virus site-specific integration and AAVS1 disruption. Journal of virology. 2004 Academic Article GET IT
Times cited: 42
Adenovirus-induced maturation of dendritic cells through a PI3 kinase-mediated TNF-alpha induction pathway. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 95
Transgene expression after rep-mediated site-specific integration into chromosome 19. Human gene therapy. 2004 Academic Article GET IT
Times cited: 24
Subgroup B and F fiber chimeras eliminate normal adenovirus type 5 vector transduction in vitro and in vivo. Journal of virology. 2003 Academic Article GET IT
Times cited: 51
A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19. Proceedings of the National Academy of Sciences of the United States of America. 2002 Academic Article GET IT
Times cited: 78
Sensitization of IFN-gamma Jak-STAT signaling during macrophage activation. Nature immunology. 2002 Academic Article GET IT
Times cited: 184
Efficient integration of recombinant adeno-associated virus DNA vectors requires a p5-rep sequence in cis. Journal of virology. 2002 Academic Article GET IT
Times cited: 58
TNF-alpha -dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection. Proceedings of the National Academy of Sciences of the United States of America. 2001 Academic Article GET IT
Times cited: 159
Variation in adenovirus transgene expression between BALB/c and C57BL/6 mice is associated with differences in interleukin-12 and gamma interferon production and NK cell activation. Journal of virology. 2001 Academic Article GET IT
Times cited: 45
Soluble CD8 attenuates cytotoxic T cell responses against replication-defective adenovirus affording transprotection of transgenes in vivo. Journal of immunology (Baltimore, Md. : 1950). 2000 Academic Article GET IT
Times cited: 7
Creation and repair of specific DNA double-strand breaks in vivo following infection with adenovirus vectors expressing Saccharomyces cerevisiae HO endonuclease. Virology. 2000 Academic Article GET IT
Times cited: 23
Fiber swap between adenovirus subgroups B and C alters intracellular trafficking of adenovirus gene transfer vectors. Journal of virology. 1999 Academic Article GET IT
Times cited: 134
Inhibition of tumor necrosis factor alpha by an adenovirus-encoded soluble fusion protein extends transgene expression in the liver and lung. Journal of virology. 1999 Academic Article GET IT
Times cited: 35
Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor. American journal of respiratory cell and molecular biology. 1999 Academic Article GET IT
Times cited: 71
Construction and characterization of hexon-chimeric adenoviruses: specification of adenovirus serotype. Journal of virology. 1998 Academic Article GET IT
Times cited: 89
Construction of an adenovirus type 7a E1A- vector. Journal of virology. 1997 Academic Article GET IT
Times cited: 38
Tumor necrosis factor alpha plays a central role in immune-mediated clearance of adenoviral vectors. Proceedings of the National Academy of Sciences of the United States of America. 1997 Academic Article GET IT
Times cited: 128
Sequence-mediated regulation of adenovirus gene expression by repression of mRNA accumulation. Molecular and cellular biology. 1997 Academic Article GET IT
Times cited: 6
Circumvention of anti-adenovirus neutralizing immunity by administration of an adenoviral vector of an alternate serotype. Human gene therapy. 1997 Academic Article GET IT
Times cited: 174
Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration. Human gene therapy. 1997 Academic Article GET IT
Times cited: 421
Delivery of human interferon-gamma via gene transfer in vitro: prolonged expression and induction of macrophage antimicrobial activity. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 1996 Academic Article GET IT
Times cited: 15
Adenovirus-mediated gene delivery into neuronal precursors of the adult mouse brain. Proceedings of the National Academy of Sciences of the United States of America. 1996 Academic Article GET IT
Times cited: 49
Adenovirus type 5 and 7 capsid chimera: fiber replacement alters receptor tropism without affecting primary immune neutralization epitopes. Journal of virology. 1996 Academic Article GET IT
Times cited: 219
Ectopic expression of thyrotropin releasing hormone (TRH) receptors in liver modulates organ function to regulate blood glucose by TRH. Nature genetics. 1996 Academic Article GET IT
Times cited: 8
Polarity of TRH receptors in transfected MDCK cells is independent of endocytosis signals and G protein coupling. The American journal of physiology. 1996 Academic Article GET IT
Times cited: 11
Circumventing the immune response to adenovirus-mediated gene therapy. Gene therapy. 1996 Academic Article GET IT
Times cited: 125
"Sero-switch" adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype. Human gene therapy. 1996 Academic Article GET IT
Times cited: 182
The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer. Gene therapy. 1994 Academic Article GET IT
Times cited: 212
Sequence elements upstream of the 3' cleavage site confer substrate strength to the adenovirus L1 and L3 polyadenylation sites. Molecular and cellular biology. 1994 Academic Article GET IT
Times cited: 37
Expression of thyrotropin-releasing hormone receptors by adenovirus-mediated gene transfer reveals that thyrotropin-releasing hormone desensitization is cell specific. Molecular pharmacology. 1994 Academic Article GET IT
Times cited: 38
Thyrotropin-releasing hormone (TRH) receptor number determines the size of the TRH-responsive phosphoinositide pool. Demonstration using controlled expression of TRH receptors by adenovirus mediated gene transfer. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 23
Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 1993 Academic Article GET IT
Times cited: 232
3' RNA processing efficiency plays a primary role in generating termination-competent RNA polymerase II elongation complexes. Molecular and cellular biology. 1993 Academic Article GET IT
Times cited: 58
Characterization of the mouse beta maj globin transcription termination region: a spacing sequence is required between the poly(A) signal sequence and multiple downstream termination elements. Molecular and cellular biology. 1993 Academic Article GET IT
Times cited: 40
Varied poly(A) site efficiency in the adenovirus major late transcription unit. The Journal of biological chemistry. 1992 Academic Article GET IT
Times cited: 29
Sequences regulating temporal poly(A) site switching in the adenovirus major late transcription unit. Molecular and cellular biology. 1991 Academic Article GET IT
Times cited: 19
Regulation of antibody secretion by hybridoma cells. II. Mechanism of idiotype-induced suppression of antibody secretion by hybridoma cells. Cellular immunology. 1989 Academic Article GET IT
Times cited: 1
Regulation of poly(A) site selection in adenovirus. Journal of virology. 1989 Academic Article GET IT
Times cited: 29
A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene. Proceedings of the National Academy of Sciences of the United States of America. 1987 Academic Article GET IT
Times cited: 159
Transcription termination within the E1A gene of adenovirus induced by insertion of the mouse beta-major globin terminator element. Cell. 1985 Academic Article GET IT
Times cited: 51
Transcription termination occurs within a 1000 base pair region downstream from the poly(A) site of the mouse beta-globin (major) gene. Nucleic acids research. 1984 Academic Article GET IT
Times cited: 40
Regiospecific arylazo substitution into alpha-amanitin with retention of inhibitory properties against eukaryotic class II RNA polymerase. International journal of peptide and protein research. 1983 Academic Article GET IT
Times cited: 3
Interaction of several class II and III RNA polymerases with two families of 7'-substituted alpha-amanitin. Biochemistry. 1982 Academic Article GET IT
Times cited: 4

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Background

education and training

Ph.D., University of Illinois 1981
B.A., North Central College 1976

Contact

full name

Erik Falck-Pedersen

primary email

efalckp@med.cornell.edu

VIVO Weill Cornell Medical College

Erik Falck-Pedersen Professor Emeritus of Microbiology and Immunology

Publications

selected publications

Background

education and training

Contact

full name

primary email