Signaling of G(alpha)(12) family of G proteins through a tyrosine kinase and a Ras-GAP. Review uri icon

Overview

abstract

  • G(12) heterotrimeric G proteins transduce signals from a number of receptors involved in the regulation of cardiovascular function. Recently, it has been discovered that these G proteins regulate the activity of Bruton's tyrosine kinase and Ras-GAP1(m) through a conserved PH-BM domain. These findings provide new insights into the signaling pathways initiated by G(12), which regulate cytoskeletal organization, cell proliferation and cardiovascular function.

publication date

  • May 1, 2000

Research

keywords

  • Heterotrimeric GTP-Binding Proteins
  • Protein-Tyrosine Kinases
  • Signal Transduction
  • ras GTPase-Activating Proteins

Identity

Scopus Document Identifier

  • 0034475134

Digital Object Identifier (DOI)

  • 10.1016/s1050-1738(00)00054-2

PubMed ID

  • 11239796

Additional Document Info

volume

  • 10

issue

  • 4