Huang, Xin-Yun

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selected publications

Corrigendum to "Hyperprogression, a challenge of PD-1/PD-L1 inhibitors treatments: potential mechanisms and coping strategies" [Biomed. Pharmacother. 150 (2022) 112949]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Article GET IT
Development and validation of an LC-MS/MS method for the quantification of fascin proteins in human serum. Bioanalysis. 2022 Review GET IT
Structures of β₁-adrenergic receptor in complex with Gs and ligands of different efficacies. Nature communications. 2022 Academic Article GET IT
Hyperprogression, a challenge of PD-1/PD-L1 inhibitors treatments: potential mechanisms and coping strategies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Review GET IT
Times cited: 2
Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nature communications. 2022 Academic Article GET IT
Times cited: 16
Structural basis and mechanism of activation of two different families of G proteins by the same GPCR. Nature structural & molecular biology. 2021 Academic Article GET IT
Times cited: 10
Fascin Inhibitors Decrease Cell Migration and Adhesion While Increase Overall Survival of Mice Bearing Bladder Cancers. Cancers. 2021 Academic Article GET IT
Times cited: 66
Fascin inhibitor increases intratumoral dendritic cell activation and anti-cancer immunity. Cell reports. 2021 Academic Article GET IT
Times cited: 11
Correction: Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2. PLoS biology. 2021 Article GET IT
Times cited: 1
Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2. PLoS biology. 2020 Academic Article GET IT
Times cited: 7
Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β₁-Adrenergic Receptor. Molecular cell. 2020 Academic Article GET IT
Times cited: 35
Anti-Metastasis Fascin Inhibitors Decrease the Growth of Specific Subtypes of Cancers. Cancers. 2020 Academic Article GET IT
Times cited: 18
Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531. eLife. 2020 Academic Article GET IT
Times cited: 5
G-protein Gα₁₃ functions as a cytoskeletal and mitochondrial regulator to restrain osteoclast function. Scientific reports. 2019 Academic Article GET IT
Times cited: 13
Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis. Gynecologic oncology. 2019 Academic Article GET IT
Times cited: 20
Signaling mechanisms and physiological functions of G-protein Gα₁₃ in blood vessel formation, bone homeostasis, and cancer. Protein science : a publication of the Protein Society. 2018 Review GET IT
Times cited: 9
Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor. Journal of molecular biology. 2018 Academic Article GET IT
Times cited: 19
G-Protein Gα₁₃ Functions with Abl Kinase to Regulate Actin Cytoskeletal Reorganization. Journal of molecular biology. 2017 Academic Article GET IT
Times cited: 4
Regulation, Signaling, and Physiological Functions of G-Proteins. Journal of molecular biology. 2016 Review GET IT
Times cited: 234
A Glial K/Cl Transporter Controls Neuronal Receptive Ending Shape by Chloride Inhibition of an rGC. Cell. 2016 Academic Article GET IT
Times cited: 54
Improving fascin inhibitors to block tumor cell migration and metastasis. Molecular oncology. 2016 Academic Article GET IT
Times cited: 50
Critical Roles of STAT3 in β-Adrenergic Functions in the Heart. Circulation. 2015 Academic Article GET IT
Times cited: 44
Ligand occupancy in crystal structure of β1-adrenergic G protein-coupled receptor. Nature structural & molecular biology. 2015 Letter GET IT
Times cited: 1
Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization. Nature communications. 2015 Academic Article GET IT
Times cited: 85
Pivotal role of extended linker 2 in the activation of Gα by G protein-coupled receptor. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 8
A signal transducer and activator of transcription 3·Nuclear Factor κB (Stat3·NFκB) complex is necessary for the expression of fascin in metastatic breast cancer cells in response to interleukin (IL)-6 and tumor necrosis factor (TNF)-α. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 51
C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 18
Atypical protein kinase Cλ is critical for growth factor receptor-induced dorsal ruffle turnover and cell migration. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 11
Defining specificity determinants of cGMP mediated gustatory sensory transduction in Caenorhabditis elegans. Genetics. 2013 Academic Article GET IT
Times cited: 26
Crystal structure of oligomeric β1-adrenergic G protein-coupled receptors in ligand-free basal state. Nature structural & molecular biology. 2013 Academic Article GET IT
Times cited: 219
Molecular mechanism of fascin function in filopodial formation. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 85
Mouse models for tumor metastasis. Methods in molecular biology (Clifton, N.J.). 2012 Academic Article GET IT
Times cited: 73
Signal transducers and activators of transcription 3 (STAT3) directly regulates cytokine-induced fascin expression and is required for breast cancer cell migration. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 80
Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 27
SUMOylation-regulated protein phosphorylation, evidence from quantitative phosphoproteomics analyses. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 49
Gα13 is closely related to hematopoiesis in zebrafish. Molecular biology reports. 2010 Academic Article GET IT
Times cited: 1
Stat3 is essential for neuronal differentiation through direct transcriptional regulation of the Sox6 gene. FEBS letters. 2010 Academic Article GET IT
Times cited: 22
A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17. Oncogene. 2010 Academic Article GET IT
Times cited: 50
Stat3 directly controls the expression of Tbx5, Nkx2.5, and GATA4 and is essential for cardiomyocyte differentiation of P19CL6 cells. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 46
Migrastatin analogues target fascin to block tumour metastasis. Nature. 2010 Academic Article GET IT
Times cited: 216
A new Rac/PAK/GC/cGMP signaling pathway. Molecular and cellular biochemistry. 2009 Review GET IT
Times cited: 15
Suppression of tumor angiogenesis by Galpha(13) haploinsufficiency. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 9
Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2009 Academic Article GET IT
Times cited: 1944
Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer. Cancer research. 2009 Academic Article GET IT
Times cited: 26
Stimulation of guanylyl cyclase-D by bicarbonate. Biochemistry. 2009 Academic Article GET IT
Times cited: 48
The minichromosome maintenance proteins 2-7 (MCM2-7) are necessary for RNA polymerase II (Pol II)-mediated transcription. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 31
PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease. PloS one. 2009 Academic Article GET IT
Times cited: 117
Orai1 and STIM1 are critical for breast tumor cell migration and metastasis. Cancer cell. 2009 Academic Article GET IT
Times cited: 534
The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning. Developmental biology. 2008 Academic Article GET IT
Times cited: 49
cAMP inhibits cell migration by interfering with Rac-induced lamellipodium formation. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 43
Identification of novel direct Stat3 target genes for control of growth and differentiation. The Journal of biological chemistry. 2007 Academic Article GET IT
Times cited: 90
Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007 Academic Article GET IT
Times cited: 139
When a G protein-coupled receptor does not couple to a G protein. Molecular bioSystems. 2007 Review GET IT
Times cited: 65
Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. International journal of radiation oncology, biology, physics. 2007 Academic Article GET IT
Times cited: 107
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007 Academic Article GET IT
Times cited: 1037
Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. Journal of neurochemistry. 2007 Academic Article GET IT
Times cited: 204
Methuselah antagonist extends life span. Nature chemical biology. 2007 Comment GET IT
Times cited: 2
GPCRs signaling directly through Src-family kinases. Science's STKE : signal transduction knowledge environment. 2007 Review GET IT
Times cited: 46
Synthetic macrolides that inhibit breast cancer cell migration in vitro. Journal of the American Chemical Society. 2007 Academic Article GET IT
Times cited: 30
A Rac-cGMP signaling pathway. Cell. 2007 Academic Article GET IT
Times cited: 80
Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. The EMBO journal. 2006 Academic Article GET IT
Times cited: 94
G proteins G12 and G13 control the dynamic turnover of growth factor-induced dorsal ruffles. The Journal of biological chemistry. 2006 Academic Article GET IT
Times cited: 22
The G protein G alpha(13) is required for growth factor-induced cell migration. Developmental cell. 2006 Academic Article GET IT
Times cited: 64
Csk mediates G-protein-coupled lysophosphatidic acid receptor-induced inhibition of membrane-bound guanylyl cyclase activity. Biochemistry. 2006 Academic Article GET IT
Times cited: 8
Role of tyrosine kinase Csk in G protein-coupled receptor- and receptor tyrosine kinase-induced fibroblast cell migration. The Journal of biological chemistry. 2006 Academic Article GET IT
Times cited: 14
Requirement of SRC-family tyrosine kinases in fat accumulation. Biochemistry. 2005 Academic Article GET IT
Times cited: 22
Binding of Src to Na+/K+-ATPase forms a functional signaling complex. Molecular biology of the cell. 2005 Academic Article GET IT
Times cited: 294
Ca2+ influx through L-type Ca2+ channels controls the trailing tail contraction in growth factor-induced fibroblast cell migration. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 131
Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 150
The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis. Journal of the American Chemical Society. 2004 Academic Article GET IT
Times cited: 158
The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila. Nature cell biology. 2004 Academic Article GET IT
Times cited: 77
Distinct roles for Src tyrosine kinase in beta2-adrenergic receptor signaling to MAPK and in receptor internalization. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 26
Discovery of potent cell migration inhibitors through total synthesis: lessons from structure-activity studies of (+)-migrastatin. Journal of the American Chemical Society. 2004 Academic Article GET IT
Times cited: 168
Csk, a critical link of g protein signals to actin cytoskeletal reorganization. Developmental cell. 2002 Academic Article GET IT
Times cited: 68
Novel regulation and function of Src tyrosine kinase. Cellular and molecular life sciences : CMLS. 2002 Review GET IT
Times cited: 54
Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization. Protein science : a publication of the Protein Society. 2002 Academic Article GET IT
Times cited: 34
Direct stimulation of Bruton's tyrosine kinase by G protein alpha subunits. Methods in enzymology. 2002 Academic Article GET IT
Times cited: 2
Novel signaling pathway through the beta-adrenergic receptor. Trends in cardiovascular medicine. 2002 Review GET IT
Times cited: 31
RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. Science (New York, N.Y.). 2001 Academic Article GET IT
Times cited: 196
G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 30
Role of the PHTH module in protein substrate recognition by Bruton's agammaglobulinemia tyrosine kinase. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 14
Molecular determinants for Csk-catalyzed tyrosine phosphorylation of the Src tail. Biochemistry. 2001 Academic Article GET IT
Times cited: 52
Regulation of ROMK1 channels by protein-tyrosine kinase and -tyrosine phosphatase. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 61
Src tyrosine kinase is a novel direct effector of G proteins. Cell. 2000 Academic Article GET IT
Times cited: 379
Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell. 2000 Academic Article GET IT
Times cited: 316
Apoptotic signaling through the beta -adrenergic receptor. A new Gs effector pathway. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 98
Signaling of G(alpha)(12) family of G proteins through a tyrosine kinase and a Ras-GAP. Trends in cardiovascular medicine. 2000 Review GET IT
Times cited: 6
Purification of an EH domain-binding protein from rat brain that modulates the gating of the rat ether-à-go-go channel. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 17
Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 23
The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain. Nature. 1998 Academic Article GET IT
Times cited: 161
Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase. Proceedings of the National Academy of Sciences of the United States of America. 1998 Academic Article GET IT
Times cited: 42
Analysis of the Gs/mitogen-activated protein kinase pathway in mutant S49 cells. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 77
Specific antibodies to the external vestibule of voltage-gated potassium channels block current. The Journal of general physiology. 1998 Academic Article GET IT
Times cited: 44
Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit. Nature. 1997 Academic Article GET IT
Times cited: 169
Genetic evidence for a tyrosine kinase cascade preceding the mitogen-activated protein kinase cascade in vertebrate G protein signaling. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 62
Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors. Nature. 1996 Academic Article GET IT
Times cited: 259
Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits. Proceedings of the National Academy of Sciences of the United States of America. 1995 Academic Article GET IT
Times cited: 127
Molecular basis of cardiac potassium channel stimulation by protein kinase A. Proceedings of the National Academy of Sciences of the United States of America. 1994 Academic Article GET IT
Times cited: 65
Tyrosine kinase-dependent suppression of a potassium channel by the G protein-coupled m1 muscarinic acetylcholine receptor. Cell. 1993 Academic Article GET IT
Times cited: 243
Conservation of gene organization and trans-splicing in the glyceraldehyde-3-phosphate dehydrogenase-encoding genes of Caenorhabditis briggsae. Gene. 1992 Academic Article GET IT
Times cited: 32
RNA trans-splicing. Genetic engineering. 1992 Review GET IT
Times cited: 13
Trans-splicing and SL RNAs in C. elegans. Molecular biology reports. 1990 Academic Article GET IT
Times cited: 2
A second trans-spliced RNA leader sequence in the nematode Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 1989 Academic Article GET IT
Times cited: 121
Genomic organization of the glyceraldehyde-3-phosphate dehydrogenase gene family of Caenorhabditis elegans. Journal of molecular biology. 1989 Academic Article GET IT
Times cited: 41

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Research

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Funding awarded

Molecular Basis of B1-Adrenergic Receptor Function awarded by National Institute of General Medical Sciences Principal Investigator 2020 - 2024

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Background

education and training

Ph.D., University of Houston 1988
B.S., Wuhan University (China) 1983

Contact

full name

Xin-Yun Huang

primary email

xyhuang@med.cornell.edu

VIVO Weill Cornell Medical College

Xin-Yun Huang Professor of Physiology and Biophysics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email