Microdialysis can detect age-related differences in glucose distribution within the dermis and subcutaneous adipose tissue. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Intrinsic (chronological) cutaneous aging is a continuous and complex process. Limitation in nutrient supply to the skin could contribute to this process. OBJECTIVE: Our study focused on the impact of age on glucose supply to human skin and its distribution within the dermis and subcutaneous adipose tissue. METHODS: An oral glucose load (100 g) was given to healthy volunteers of two age groups (24 +/- 4 and 59 +/- 10 years, n = 4 for each group). Dialysate concentrations of glucose and glycerol were monitored by microdialysis in the dermis and adipose tissue. RESULTS: Baseline tissue [glucose] did not differ significantly between the two groups. After the glucose load, dialysate [glucose] of the dermis peaked between 60 and 80 min and between 80 and 120 min in the young and old groups, respectively. In the old group, dialysate [glucose] was significantly higher in the dermis than adipose tissue at 80, 100, 120, 160 and 180 min after the load. The sum of the areas under the curve (dermis + adipose tissue) did not differ significantly between the two age groups. CONCLUSIONS: Aging is accompanied by an increased diffusion barrier for glucose between the dermis and adipose tissue.

publication date

  • January 1, 2001

Research

keywords

  • Adipose Tissue
  • Aging
  • Dermis
  • Glucose

Identity

Scopus Document Identifier

  • 0034980463

Digital Object Identifier (DOI)

  • 10.1159/000051638

PubMed ID

  • 11385225

Additional Document Info

volume

  • 202

issue

  • 3