STI571: a paradigm of new agents for cancer therapeutics. Review uri icon

Overview

abstract

  • STI571 exemplifies the successful development of a rationally designed, molecularly targeted therapy for the treatment of a specific cancer. This article reviews the identification of Bcr-Abl as a therapeutic target in chronic myelogenous leukemia and the steps in the development of an agent to specifically inactivate this abnormality. Issues related to clinical trials of molecularly targeted agents are discussed, including dose selection, optimizing therapy, and predicting response, as are possible mechanisms of resistance to STI571. Lastly, the potential use of STI571 in other malignancies and the translation of this paradigm to other malignancies are explored.

publication date

  • January 1, 2002

Research

keywords

  • Antineoplastic Agents
  • Drug Design
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Piperazines
  • Pyrimidines

Identity

Scopus Document Identifier

  • 0036139993

Digital Object Identifier (DOI)

  • 10.1200/JCO.2002.20.1.325

PubMed ID

  • 11773186

Additional Document Info

volume

  • 20

issue

  • 1