Ubiquinol and a coenzyme Q reducing system protect platelet mitochondrial function of transfusional buffy coats from oxidative stress. Academic Article uri icon

Overview

abstract

  • The conditions under which Coenzyme Q (CoQ) may protect platelet mitochondrial function of transfusional buffy coats from aging and from induced oxidative stress were investigated. The Pasteur effect, i.e. the enhancement of lactate production after inhibition of mitochondrial respiratory chain, was exploited as a marker of mitochondrial function as it allows to calculate the ratio of mitochondrial ATP to glycolytic ATP. Reduced CoQ10 improves platelet mitochondrial function of transfusional buffy coats and protects the cells from induced oxidative stress. Oxidized CoQ is usually less effective, despite the presence, shown for the first time in this study, of quinone reductase activities in the platelet plasma membranes. The addition of a CoQ reducing system to platelets is effective in enhancing the protection of platelet mitochondrial function from the oxidative stress. The results support on one hand a possibility of protection of mitochondrial function in aging by exogenous CoQ intake, on the other a possible application in protection of transfusional buffy coats from storage conditions and oxidative deterioration.

publication date

  • April 1, 2002

Research

keywords

  • Aging
  • Antioxidants
  • Blood Platelets
  • Mitochondria
  • Oxidative Stress
  • Ubiquinone

Identity

Scopus Document Identifier

  • 18644383865

Digital Object Identifier (DOI)

  • 10.1080/10715760290021289

PubMed ID

  • 12069107

Additional Document Info

volume

  • 36

issue

  • 4