Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation. Academic Article uri icon

Overview

abstract

  • Neonatal microglial cells respond to GM-CSF and M-CSF by acquiring different morphologies and phenotypes. To investigate the extent and consequences of this process, a global gene expression analysis was performed, with significant changes in transcript levels confirmed by biochemical analyses. Primary murine microglial cells underwent substantial expression reprogramming after treatment with GM-CSF or M-CSF with many differentially expressed transcripts important in innate and adaptive immunity. In particular, many gene products involved in Ag presentation were induced by GM-CSF, but not M-CSF, thus potentially priming relatively quiescent microglia cells for Ag presentation. This function of GM-CSF is distinct from its primary function in cell proliferation and survival.

publication date

  • September 1, 2002

Research

keywords

  • Animals, Newborn
  • Antigen Presentation
  • Gene Expression Profiling
  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Microglia

Identity

Scopus Document Identifier

  • 0036721843

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.169.5.2264

PubMed ID

  • 12193691

Additional Document Info

volume

  • 169

issue

  • 5