Na+ block and permeation in a K+ channel of known structure. Academic Article uri icon

Overview

abstract

  • The effects of intracellular Na(+) were studied on K(+) and Rb(+) currents through single KcsA channels. At low voltage, Na(+) produces voltage-dependent block, which becomes relieved at high voltage by a "punchthrough" mechanism representing Na(+) escaping from its blocking site through the selectivity filter. The Na(+) blocking site is located in the wide, hydrated vestibule, and it displays unexpected selectivity for K(+) and Rb(+) against Na(+). The voltage dependence of Na(+) block reflects coordinated movements of the blocker with permeant ions in the selectivity filter.

publication date

  • September 1, 2002

Research

keywords

  • Bacterial Proteins
  • Cell Membrane Permeability
  • Membranes, Artificial
  • Potassium Channels
  • Sodium

Identity

PubMed Central ID

  • PMC2229518

Scopus Document Identifier

  • 0036714139

Digital Object Identifier (DOI)

  • 10.1085/jgp.20028614

PubMed ID

  • 12198089

Additional Document Info

volume

  • 120

issue

  • 3