The Journal of general physiology

publication venue for

Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function.. 155. 2023
Directing two-way traffic in the kidney: A tale of two ions.. 154. 2022
Expression of ENaC subunits in epithelia.. 154. 2022
The archaeal glutamate transporter homologue GltPh shows heterogeneous substrate binding.. 154. 2022
The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism.. 154. 2021
ENaC and ROMK channels in the connecting tubule regulate renal K+ secretion.. 153. 2021
Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity.. 153. 2021
An interaction between the III-IV linker and CTD in NaV1.5 confers regulation of inactivation by CaM and FHF.. 152. 2020
Antidepressants are modifiers of lipid bilayer properties.. 151. 2019
Determinants of selective ion permeation in the epithelial Na⁺ channel.. 150. 2018
A two-step docking site model predicting different short-term synaptic plasticity patterns.. 150. 2018
Ligand binding and activation properties of the purified bacterial cyclic nucleotide-gated channel SthK.. 150. 2018
Isoflurane modulates activation and inactivation gating of the prokaryotic Na⁺ channel NaChBac.. 149. 2017
Probing the conformation of a conserved glutamic acid within the Cl^- pathway of a CLC H⁺/Cl^- exchanger.. 149. 2017
Calmodulin limits pathogenic Na+ channel persistent current.. 149. 2017
Soluble adenylyl cyclase is essential for proper lysosomal acidification.. 148. 2016
Conformational heterogeneity in closed and open states of the KcsA potassium channel in lipid bicelles.. 148. 2016
Regulation of ENaC trafficking in rat kidney.. 147. 2016
A general mechanism for drug promiscuity: Studies with amiodarone and other antiarrhythmics.. 146. 2015
Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties.. 144. 2014
Ion conduction and selectivity in acid-sensing ion channel 1.. 144. 2014
Molecular interactions involved in proton-dependent gating in KcsA potassium channels.. 142. 2013
Phosphoinositides alter lipid bilayer properties.. 141. 2013
Perspectives on: conformational coupling in ion channels.. 140. 2012
Preferential binding of K+ ions in the selectivity filter at equilibrium explains high selectivity of K+ channels.. 140. 2012
Interactions of external K+ and internal blockers in a weak inward-rectifier K+ channel.. 140. 2012
Ion selectivity and current saturation in inward-rectifier K+ channels.. 139. 2012
Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery.. 138. 2011
Perspectives on: Ion selectivity.. 137. 2011
Non-vesicular transfer of membrane proteins from nanoparticles to lipid bilayers.. 137. 2011
Proton block of the CLC-5 Cl-/H+ exchanger.. 135. 2010
The two-membrane model of epithelial transport: Koefoed-Johnsen and Ussing (1958).. 132. 2008
Long-pore electrostatics in inward-rectifier potassium channels.. 132. 2008
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells.. 132. 2008
Surface expression of epithelial Na channel protein in rat kidney.. 131. 2008
Lipid bilayer-mediated regulation of ion channel function by amphiphilic drugs.. 131. 2008
Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP.. 130. 2007
Determination of epithelial Na+ channel subunit stoichiometry from single-channel conductances.. 130. 2007
Uncoupling and turnover in a Cl-/H+ exchange transporter.. 129. 2007
Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases.. 128. 2006
Calcium-dependent gating of MthK, a prokaryotic potassium channel.. 127. 2006
Regulation of connexin hemichannels by monovalent cations.. 127. 2006
Separate ion pathways in a Cl-/H+ exchanger.. 126. 2005
A brief history of the journal of general physiology.. 125. 2005
Carboxy-terminal determinants of conductance in inward-rectifier K channels.. 124. 2004
On the importance of atomic fluctuations, protein flexibility, and solvent in ion permeation.. 124. 2004
A cyclic nucleotide modulated prokaryotic K+ channel.. 124. 2004
Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol.. 123. 2004
Regulation of Kir channels by intracellular pH and extracellular K(+): mechanisms of coupling.. 123. 2004
Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels.. 123. 2004
Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels.. 123. 2003
Conformational changes in the pore of CLC-0.. 122. 2003
Hydrophobic coupling of lipid bilayer energetics to channel function.. 121. 2003
Slo1 tail domains, but not the Ca2+ bowl, are required for the beta 1 subunit to increase the apparent Ca2+ sensitivity of BK channels.. 120. 2002
Na+ block and permeation in a K+ channel of known structure.. 120. 2002
Mechanism of block of single protopores of the Torpedo chloride channel ClC-0 by 2-(p-chlorophenoxy)butyric acid (CPB).. 118. 2001
Fast and slow gating relaxations in the muscle chloride channel CLC-1.. 116. 2000
Functional coupling of the beta(1) subunit to the large conductance Ca(2+)-activated K(+) channel in the absence of Ca(2+). Increased Ca(2+) sensitivity from a Ca(2+)-independent mechanism.. 115. 2000
Permeation properties of inward-rectifier potassium channels and their molecular determinants.. 115. 2000
Perspectives on ion permeation.. 113. 1999
The beta subunit increases the Ca2+ sensitivity of large conductance Ca2+-activated potassium channels by retaining the gating in the bursting states.. 113. 1999
Perspectives on ion channel assembly.. 113. 1999
Reversible Ca gradients between the subplasmalemma and cytosol differentially activate Ca-dependent Cl currents.. 113. 1999
Editorial.. 113. 1999
Permeation and gating of an inwardly rectifying potassium channel. Evidence for a variable energy well.. 112. 1998
Editorial: perspectives in general physiology.. 111. 1998
Specific antibodies to the external vestibule of voltage-gated potassium channels block current.. 111. 1998
The 51st annual meeting and symposium of the society of general physiologists. Mechanisms Of secretion.. 111. 1998
Editorial.. 111. 1998
Epithelial Na channels. Why all the subunits?. 109. 1997
Gating of Na channels in the rat cortical collecting tubule: effects of voltage and membrane stretch.. 107. 1996
A kinetically defined Na+/H+ antiporter within a mathematical model of the rat proximal tubule.. 105. 1995
Lysophospholipids modulate channel function by altering the mechanical properties of lipid bilayers.. 104. 1994
Regulation of apical K and Na channels and Na/K pumps in rat cortical collecting tubule by dietary K.. 104. 1994
Shaker potassium channel gating. II: Transitions in the activation pathway.. 103. 1994
Regulation of Na channels of the rat cortical collecting tubule by aldosterone.. 102. 1993
Regulation of the Na-K pump of the rat cortical collecting tubule by aldosterone.. 102. 1993
Expression of multiple water channel activities in Xenopus oocytes injected with mRNA from rat kidney.. 101. 1993
Proton block of rat brain sodium channels. Evidence for two proton binding sites and multiple occupancy.. 101. 1993
Steady-state gating of batrachotoxin-modified sodium channels. Variability and electrolyte-dependent modulation.. 98. 1991
Circadian rhythms in Limulus photoreceptors. II. Quantum bumps.. 96. 1990
Volume-activated chloride permeability can mediate cell volume regulation in a mathematical model of a tight epithelium.. 96. 1990
Expression of epithelial Na channels in Xenopus oocytes.. 96. 1990
Functional carboxyl groups in the red cell anion exchange protein. Modification with an impermeant carbodiimide.. 93. 1989
Osmotic water permeability of Necturus gallbladder epithelium.. 93. 1989
Conductance and gating of epithelial Na channels from rat cortical collecting tubule. Effects of luminal Na and Li.. 92. 1988
Batrachotoxin-modified sodium channels in planar lipid bilayers. Characterization of saxitoxin- and tetrodotoxin-induced channel closures.. 89. 1987
Batrachotoxin-modified sodium channels in planar lipid bilayers. Ion permeation and block.. 89. 1987
Convective paracellular solute flux. A source of ion-ion interaction in the epithelial transport equations.. 89. 1987
Intrinsic characteristics of the proton pump in the luminal membrane of a tight urinary epithelium. The relation between transport rate and delta mu H.. 86. 1985
Monazomycin-induced single channels. I. Characterization of the elementary conductance events.. 80. 1982
Monazomycin-induced single channels. II. Origin of the voltage dependence of the macroscopic conductance.. 80. 1982
The nonlinear pathway of Y ganglion cells in the cat retina.. 74. 1979
Calcium distribution in Amoeba proteus.. 74. 1979
Sucrose uptake by pinocytosis in Amoeba proteus and the influence of external calcium.. 74. 1979
Receptive field mechanisms of cat X and Y retinal ganglion cells.. 74. 1979
Effect of phloretin on the permeability of thin lipid membranes.. 67. 1976
Perspectives on: The response to osmotic challenges.. 145. 2015
Perspectives on how to drug an ion channel.. 131. 2008
Not so transport incompetent after all: Revisiting a CLC-7 mutant sheds new mechanistic light on lysosomal physiology. 2021
Polyamine block of MthK potassium channels. 2020
Cells on the MEND: exploring the role of lipidic forces in membrane trafficking. 2011
To ATP or not to ATP: this is the question. 2008
Amyloid ion channels: a porous argument or a thin excuse? 2006
The 60th symposium of the Society of General Physiologists. Chemotaxis, invasion, and phagocytosis: from bacteria to humans. (Organised by Sergio Grinstein and Joseph J. Falke). 2007
The 59th Symposium of the Society of General Physiologists. Na,K-ATPase and related cation pumps: structures, mechanisms, and diseases. 2006
The 58th annual meeting and symposium of the society of general physiologists: lipid signaling in physiology. 2005
The 57th Annual Meeting and Symposium of the Society of General Physiologists: the biology of chloride. 2004
The 56th Annual Meeting and Symposium of the Society of General Physiologists: trafficking of transporters. 2003
The 55th Annual Meeting and Symposium of the Society of General Physiologists: molecular motors. 2002
The 54th Annual Meeting and Symposium of the Society of General Physiologists: structures and mechanisms of channels and transport proteins. 2001
The 52nd annual meeting and symposium of the Society of General Physiologists. Local calcium signaling in cell physiology. 1999
The 50th Annual Meeting and Symposium of the Society of General Physiologists. Cytoskeletal regulation of membrane function. 1997
Models and mechanistic insight.. 131. 2008
Editorial.. 125. 2005
Graphic representation of the results of kinetic analyses.. 114. 1999
The Journal of General Physiology.. 109. 1997
Known structures and unknown mechanisms of TMEM16 scramblases and channels. 2018
Epithelial transport in The Journal of General Physiology. 2017
Origins of ion selectivity in potassium channels from the perspective of channel block. 2011

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