Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae. Academic Article uri icon

Overview

abstract

  • Many glucosamine residues of the pneumococcal peptidoglycan (PG) are not acetylated, which makes the PG resistant to lysozyme. A capsular type III mutant with an inactivated pgdA gene (encoding the peptidoglycan N-acetylglucosamine deacetylase A) became hypersensitive to exogenous lysozyme and showed reduced virulence in the intraperitoneal mouse model.

publication date

  • December 1, 2002

Research

keywords

  • Amidohydrolases
  • Bacterial Proteins
  • Streptococcus pneumoniae

Identity

PubMed Central ID

  • PMC133073

Scopus Document Identifier

  • 0036892246

Digital Object Identifier (DOI)

  • 10.1128/IAI.70.12.7176-7178.2002

PubMed ID

  • 12438406

Additional Document Info

volume

  • 70

issue

  • 12