NF-kappaB activation by protein kinase C isoforms and B-cell function. Review uri icon

Overview

abstract

  • B cells are essential to the immune response in health and disease. Results from knockout (KO) mice for different members of the nuclear factor-kappaB (NF-kappaB) family have highlighted the importance of this transcription factor in B cell development and function. The recent generation of additional KO mice for adapters and kinases implicated in NF-kappaB activation, including several protein kinase C isoforms, has provided new insights into the roles of these proteins in B cell signalling. These studies have also given rise to a number of important questions that must be answered with further experimentation to establish accurately the signalling pathways that regulate B-cell function through NF-kappaB.

publication date

  • January 1, 2003

Research

keywords

  • B-Lymphocytes
  • NF-kappa B
  • Protein Kinase C
  • Receptors, Antigen, B-Cell

Identity

PubMed Central ID

  • PMC1315804

Scopus Document Identifier

  • 0037223086

Digital Object Identifier (DOI)

  • 10.1038/sj.embor.embor704

PubMed ID

  • 12524517

Additional Document Info

volume

  • 4

issue

  • 1