Moscat, Jorge

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selected publications

Sessile serrated lesions with dysplasia: is it possible to nip them in the bud?. Journal of gastroenterology. 2023 Academic Article GET IT
Whole-mount staining of mouse colorectal cancer organoids and fibroblast-organoid co-cultures. STAR protocols. 2023 Academic Article GET IT
Times cited: 25
Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer. Cancer cell. 2022 Academic Article GET IT
Times cited: 3
Air-liquid organotypic assays to investigate cellular crosstalk in the tumor microenvironment of cancer cells. STAR protocols. 2022 Academic Article GET IT
The lactate-NAD⁺ axis activates cancer-associated fibroblasts by downregulating p62. Cell reports. 2022 Academic Article GET IT
Times cited: 12
Protein kinase Cλ/ι in cancer: a contextual balance of time and signals. Trends in cell biology. 2022 Review GET IT
Times cited: 2
S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022 Academic Article GET IT
Times cited: 9
Immunosurveillance, interferon, and autophagic networking in cancer: the PRKCI-ULK2 paradigm. Autophagy. 2021 Academic Article GET IT
Times cited: 2
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis. Molecular cell. 2021 Academic Article GET IT
Times cited: 7
NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ. Nature communications. 2021 Academic Article GET IT
Times cited: 9
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. Cancer cell. 2021 Academic Article GET IT
Times cited: 62
Mouse model of colorectal cancer: orthotopic co-implantation of tumor and stroma cells in cecum and rectum. STAR protocols. 2021 Academic Article GET IT
Times cited: 9
Correction: p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis. Cancer research. 2020 Academic Article GET IT
An Orthotopic Implantation Mouse Model of Hepatocellular Carcinoma with Underlying Liver Steatosis. STAR protocols. 2020 Academic Article GET IT
Times cited: 4
Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population. Developmental cell. 2020 Academic Article GET IT
Times cited: 27
Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Blood. 2020 Academic Article GET IT
Times cited: 17
Deconstructing tumor heterogeneity: the stromal perspective. Oncotarget. 2020 Academic Article GET IT
Times cited: 19
Fructose stimulated de novo lipogenesis is promoted by inflammation. Nature metabolism. 2020 Academic Article GET IT
Times cited: 125
The interplay between PRKCI/PKCλ/ι, SQSTM1/p62, and autophagy orchestrates the oxidative metabolic response that drives liver cancer. Autophagy. 2020 Comment GET IT
Times cited: 4
PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. Cancer cell. 2020 Academic Article GET IT
Times cited: 60
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation. Nature communications. 2020 Academic Article GET IT
Times cited: 20
NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly. Journal of hepatology. 2020 Academic Article GET IT
Times cited: 50
The complexity of the serine glycine one-carbon pathway in cancer. The Journal of cell biology. 2020 Review GET IT
Times cited: 54
Serrated Colorectal Cancer: The Road Less Travelled?. Trends in cancer. 2019 Review GET IT
Times cited: 26
The Dual Roles of the Atypical Protein Kinase Cs in Cancer. Cancer cell. 2019 Review GET IT
Times cited: 42
Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer. Cancer cell. 2019 Academic Article GET IT
Times cited: 105
The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors. Nature communications. 2019 Academic Article GET IT
Times cited: 13
p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors. Cancer cell. 2018 Academic Article GET IT
Times cited: 41
Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance. Immunity. 2018 Academic Article GET IT
Times cited: 29
ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nature communications. 2018 Academic Article GET IT
Times cited: 58
The macroenviromental control of cancer metabolism by p62. Cell cycle (Georgetown, Tex.). 2018 Review GET IT
Times cited: 10
Metabolic reprogramming of the tumor microenvironment by p62 and its partners. Biochimica et biophysica acta. Reviews on cancer. 2018 Review GET IT
Times cited: 26
The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer. Cell reports. 2018 Academic Article GET IT
Times cited: 44
Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor. Cancer cell. 2018 Academic Article GET IT
Times cited: 71
Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer cell. 2017 Academic Article GET IT
Times cited: 91
ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Cell metabolism. 2017 Academic Article GET IT
Times cited: 68
Correction for Linares et al., "Phosphorylation of p62 by cdk1 Controls the Timely Transit of Cells through Mitosis and Tumor Cell Proliferation". Molecular and cellular biology. 2017 Academic Article GET IT
Times cited: 1
Metabolism shapes the tumor microenvironment. Current opinion in cell biology. 2017 Review GET IT
Times cited: 174
p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis. Cancer research. 2017 Academic Article GET IT
Times cited: 38
Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy. Molecular cell. 2017 Academic Article GET IT
Times cited: 187
p62 in Cancer: Signaling Adaptor Beyond Autophagy. Cell. 2016 Review GET IT
Times cited: 277
p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer. Cancer cell. 2016 Academic Article GET IT
Times cited: 166
miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3. Cancer research. 2016 Academic Article GET IT
Times cited: 44
Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι. Cell reports. 2016 Academic Article GET IT
Times cited: 40
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer cell. 2016 Academic Article GET IT
Times cited: 302
Nuclear fallout provides a new link between aPKC and polarized cell trafficking. BMC biology. 2016 Academic Article GET IT
Times cited: 4
TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis. Molecular cell. 2016 Article GET IT
Times cited: 42
TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis. Molecular cell. 2016 Academic Article GET IT
Times cited: 121
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Academic Article GET IT
Times cited: 723
Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade. Cell reports. 2015 Academic Article GET IT
Times cited: 82
Nutrient stress revamps cancer cell metabolism. Cell research. 2015 Academic Article GET IT
Times cited: 6
Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ. Cell reports. 2015 Academic Article GET IT
Times cited: 57
p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche. Cell reports. 2014 Academic Article GET IT
Times cited: 50
A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity. Cell metabolism. 2014 Academic Article GET IT
Times cited: 34
Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking. Journal of cell science. 2014 Academic Article GET IT
Times cited: 21
Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis. Cancer cell. 2014 Academic Article GET IT
Times cited: 233
SQSTM1/p62 interacts with HDAC6 and regulates deacetylase activity. PloS one. 2013 Academic Article GET IT
Times cited: 85
K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells. Molecular cell. 2013 Academic Article GET IT
Times cited: 189
Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. The Journal of clinical investigation. 2013 Academic Article GET IT
Times cited: 94
c-Myc phosphorylation by PKCζ represses prostate tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 42
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Cell. 2013 Academic Article GET IT
Times cited: 143
p62 links β-adrenergic input to mitochondrial function and thermogenesis. The Journal of clinical investigation. 2012 Academic Article GET IT
Times cited: 103
A role for sequestosome 1/p62 in mitochondrial dynamics, import and genome integrity. Biochimica et biophysica acta. 2012 Academic Article GET IT
Times cited: 61
Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance. Adipocyte. 2012 Academic Article GET IT
Times cited: 65
TRAF6 and p62 inhibit amyloid β-induced neuronal death through p75 neurotrophin receptor. Neurochemistry international. 2012 Academic Article GET IT
Times cited: 33
Th1/Th2 Differentiation and B Cell Function by the Atypical PKCs and Their Regulators. Frontiers in immunology. 2012 Academic Article GET IT
Times cited: 8
p62: a versatile multitasker takes on cancer. Trends in biochemical sciences. 2012 Review GET IT
Times cited: 198
The atypical PKCs in inflammation: NF-κB and beyond. Immunological reviews. 2012 Review GET IT
Times cited: 95
Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 29
Feedback on fat: p62-mTORC1-autophagy connections. Cell. 2011 Review GET IT
Times cited: 121
p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Molecular cell. 2011 Academic Article GET IT
Times cited: 390
Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 43
Fine tuning NF-κB: new openings for PKC-ζ. Nature immunology. 2011 Comment GET IT
Times cited: 5
Phosphorylation of p62 by cdk1 controls the timely transit of cells through mitosis and tumor cell proliferation. Molecular and cellular biology. 2010 Academic Article GET IT
Times cited: 41
NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo. The EMBO journal. 2010 Academic Article GET IT
Times cited: 28
PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. Cell metabolism. 2010 Academic Article GET IT
Times cited: 26
G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR). The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 29
A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis. EMBO reports. 2010 Academic Article GET IT
Times cited: 69
Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 53
Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex. Cell death and differentiation. 2009 Review GET IT
Times cited: 64
To aggregate or not to aggregate? A new role for p62. EMBO reports. 2009 Academic Article GET IT
Times cited: 27
p62 at the crossroads of autophagy, apoptosis, and cancer. Cell. 2009 Review GET IT
Times cited: 862
Nephrin deficiency activates NF-kappaB and promotes glomerular injury. Journal of the American Society of Nephrology : JASN. 2009 Academic Article GET IT
Times cited: 53
Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 31
Regulation of macrophage activation and septic shock susceptibility via p21(WAF1/CIP1). European journal of immunology. 2009 Academic Article GET IT
Times cited: 53
Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 33
Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo. Molecular and cellular biology. 2008 Academic Article GET IT
Times cited: 67
Akt regulation and lung cancer: a novel role and mechanism of action for the tumor suppressor Par-4. Cell cycle (Georgetown, Tex.). 2008 Academic Article GET IT
Times cited: 9
Ouabain inhibits p38 activation in thymocytes. Cell biology international. 2008 Academic Article GET IT
Times cited: 21
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis. The EMBO journal. 2008 Academic Article GET IT
Times cited: 60
Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration. Journal of neurochemistry. 2008 Academic Article GET IT
Times cited: 194
Polarized subcellular localization of Jak/STAT components is required for efficient signaling. Current biology : CB. 2008 Academic Article GET IT
Times cited: 18
The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis. Cancer cell. 2008 Academic Article GET IT
Times cited: 459
Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 151
Inactivation of the candidate tumor suppressor par-4 in endometrial cancer. Cancer research. 2007 Academic Article GET IT
Times cited: 76
Signal integration and diversification through the p62 scaffold protein. Trends in biochemical sciences. 2006 Review GET IT
Times cited: 287
Cell signaling and function organized by PB1 domain interactions. Molecular cell. 2006 Review GET IT
Times cited: 151
The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation. The EMBO journal. 2006 Academic Article GET IT
Times cited: 44
PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways. Cell death and differentiation. 2006 Review GET IT
Times cited: 107
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell metabolism. 2006 Academic Article GET IT
Times cited: 256
The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 174
Control of T helper 2 cell function and allergic airway inflammation by PKCzeta. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 79
Tumour-suppression activity of the proapoptotic regulator Par4. EMBO reports. 2005 Academic Article GET IT
Times cited: 82
Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 132
Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis. The EMBO journal. 2004 Academic Article GET IT
Times cited: 44
The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling. The Journal of cell biology. 2004 Academic Article GET IT
Times cited: 74
DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. The Journal of cell biology. 2004 Academic Article GET IT
Times cited: 193
The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Developmental cell. 2004 Academic Article GET IT
Times cited: 265
Regulation of mature T lymphocyte proliferation and differentiation by Par-4. The EMBO journal. 2003 Academic Article GET IT
Times cited: 40
Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation. The EMBO journal. 2003 Academic Article GET IT
Times cited: 272
Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38. EMBO reports. 2003 Academic Article GET IT
Times cited: 50
NF-kappaB activation by protein kinase C isoforms and B-cell function. EMBO reports. 2003 Review GET IT
Times cited: 103
Par-4 keeps the atypical PKCs at bay. Cell cycle (Georgetown, Tex.). 2003 Academic Article GET IT
Times cited: 9
The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway. Molecular and cellular biology. 2002 Academic Article GET IT
Times cited: 56
Role of zeta PKC in B-cell signaling and function. The EMBO journal. 2002 Academic Article GET IT
Times cited: 116
OPR, PC and AID: all in the PB1 family. Trends in biochemical sciences. 2002 Letter GET IT
Times cited: 55
The atypical PKC scaffold protein P62 is a novel target for anti-inflammatory and anti-cancer therapies. Advances in enzyme regulation. 2002 Academic Article GET IT
Times cited: 10
Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Molecular cell. 2001 Academic Article GET IT
Times cited: 326
MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling. Molecular and cellular biology. 2001 Academic Article GET IT
Times cited: 60
The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 147
Regulation and role of the atypical PKC isoforms in cell survival during tumor transformation. Advances in enzyme regulation. 2001 Academic Article GET IT
Times cited: 10
The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters. EMBO reports. 2000 Review GET IT
Times cited: 191
The ins and outs of protein phosphorylation. Workshop report: control of signaling by protein phosphorylation. EMBO reports. 2000 Conference Paper GET IT
Times cited: 2
The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 176
The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. The Journal of cell biology. 2000 Academic Article GET IT
Times cited: 285
The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. The EMBO journal. 2000 Academic Article GET IT
Times cited: 366
The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. The EMBO journal. 1999 Academic Article GET IT
Times cited: 102
Insulin activates protein kinases C-zeta and C-lambda by an autophosphorylation-dependent mechanism and stimulates their translocation to GLUT4 vesicles and other membrane fractions in rat adipocytes. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 190
Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 101
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. The EMBO journal. 1999 Academic Article GET IT
Times cited: 331
Cleavage of zetaPKC but not lambda/iotaPKC by caspase-3 during UV-induced apoptosis. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 83
Activation of IkappaB kinase beta by protein kinase C isoforms. Molecular and cellular biology. 1999 Academic Article GET IT
Times cited: 329
Effects of transiently expressed atypical (zeta, lambda), conventional (alpha, beta) and novel (delta, epsilon) protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat adipocytes: specific interchangeable effects of protein kinases C-zeta and C-lambda. The Biochemical journal. 1999 Academic Article GET IT
Times cited: 129
Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Molecular and cellular biology. 1998 Academic Article GET IT
Times cited: 201
The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 232
Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 409
Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes. Endocrinology. 1997 Academic Article GET IT
Times cited: 209
Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade. Molecular and cellular biology. 1997 Academic Article GET IT
Times cited: 161
Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase. Molecular and cellular biology. 1997 Academic Article GET IT
Times cited: 263
Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 276
The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Cell. 1996 Academic Article GET IT
Times cited: 328
Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 57
Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo. Molecular and cellular biology. 1996 Academic Article GET IT
Times cited: 111
Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes. Journal of virology. 1996 Academic Article GET IT
Times cited: 77
Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta. The EMBO journal. 1995 Academic Article GET IT
Times cited: 254
Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 73
Identification of heterogeneous ribonucleoprotein A1 as a novel substrate for protein kinase C zeta. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 80
Molecular characterization of a novel transcription factor that controls stromelysin expression. Molecular and cellular biology. 1995 Academic Article GET IT
Times cited: 29
Alterations in levels of different protein kinase C isotypes and their influence on behavior of squamous cell carcinoma of the oral cavity: epsilon PKC, a novel prognostic factor for relapse and survival. Head & neck. 1995 Academic Article GET IT
Times cited: 43
Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 199
Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 444
zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro. The EMBO journal. 1994 Academic Article GET IT
Times cited: 219
Zeta PKC plays a critical role during stromelysin promoter activation by platelet-derived growth factor through a novel palindromic element. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 37
NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus acquire a transformed phenotype. Molecular and cellular biology. 1994 Academic Article GET IT
Times cited: 49
Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction. Molecular and cellular biology. 1993 Academic Article GET IT
Times cited: 119
Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes. Journal of virology. 1993 Academic Article GET IT
Times cited: 98
Protein kinase C zeta isoform is critical for mitogenic signal transduction. Cell. 1993 Academic Article GET IT
Times cited: 344
A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation. Molecular and cellular biology. 1993 Academic Article GET IT
Times cited: 211
Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes. Molecular and cellular biology. 1993 Academic Article GET IT
Times cited: 115
Hydrolysis of phosphatidylcholine is stimulated by Ras proteins during mitogenic signal transduction. Molecular and cellular biology. 1992 Academic Article GET IT
Times cited: 50
Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes. Molecular and cellular biology. 1992 Academic Article GET IT
Times cited: 142
Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals. Molecular and cellular biology. 1992 Academic Article GET IT
Times cited: 31
Protein kinase C-independent expression of stromelysin by platelet-derived growth factor, ras oncogene, and phosphatidylcholine-hydrolyzing phospholipase C. The Journal of biological chemistry. 1991 Academic Article GET IT
Times cited: 31
Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. The EMBO journal. 1991 Academic Article GET IT
Times cited: 28
Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21. The Journal of biological chemistry. 1991 Academic Article GET IT
Times cited: 50
Mechanism of inhibition of adenylate cyclase by phospholipase C-catalyzed hydrolysis of phosphatidylcholine. Involvement of a pertussis toxin-sensitive G protein and protein kinase C. The Journal of biological chemistry. 1991 Academic Article GET IT
Times cited: 29
Effect of ethanol on arachidonic acid metabolism in macrophages. Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques. 1991 Academic Article GET IT
Evidence for a role of phosphatidylcholine-hydrolysing phospholipase C in the regulation of protein kinase C by ras and src oncogenes. The EMBO journal. 1990 Academic Article GET IT
Times cited: 73
Phospholipase C-mediated hydrolysis of phosphatidylcholine is an important step in PDGF-stimulated DNA synthesis. Cell. 1990 Academic Article GET IT
Times cited: 119
Kinetic evidence of a rapid activation of phosphatidylcholine hydrolysis by Ki-ras oncogene. Possible involvement in late steps of the mitogenic cascade. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 39
Activation of phosphatidylcholine-specific phospholipase C in cell growth and oncogene transformation. Biochemical Society transactions. 1989 Review GET IT
Times cited: 21
Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by muscarinic agonists. The Biochemical journal. 1989 Academic Article GET IT
Times cited: 26
The calcium signal for Balb/MK keratinocyte terminal differentiation induces sustained alterations in phosphoinositide metabolism without detectable protein kinase C activation. The Journal of biological chemistry. 1989 Academic Article GET IT
Times cited: 40
Ca2+-induced changes in the secondary structure of a 60 kDa phosphoinositide-specific phospholipase C from bovine brain cytosol. The Biochemical journal. 1988 Academic Article GET IT
Times cited: 9
Epidermal growth factor activates phosphoinositide turnover and protein kinase C in BALB/MK keratinocytes. Molecular endocrinology (Baltimore, Md.). 1988 Academic Article GET IT
Times cited: 24
Endothelial cell growth factor and ionophore A23187 stimulation of production of inositol phosphates in porcine aorta endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 1988 Academic Article GET IT
Times cited: 14
Effect of ethanol on the arachidonic acid metabolism in mouse peritoneal macrophages. Prostaglandins. 1987 Academic Article GET IT
Times cited: 3
Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene. Nature. 1987 Academic Article GET IT
Times cited: 200
Rapid stimulation of diacylglycerol production in Xenopus oocytes by microinjection of H-ras p21. Science (New York, N.Y.). 1987 Academic Article GET IT
Times cited: 86
Mitogenic activity and inositide metabolism in thrombin-stimulated pig aorta endothelial cells. Biochemical and biophysical research communications. 1987 Academic Article GET IT
Times cited: 13
Zymosan-induced release of inositol phosphates at resting cytosolic Ca2+ concentrations in macrophages. The Biochemical journal. 1987 Academic Article GET IT
Times cited: 7
A new family with hereditary choreo-acanthocytosis. 1987 GET IT
Times cited: 8
Effects of Escherichia coli lipopolysaccharide on the phosphoinositide metabolism and serotonin secretion in thrombin-activated platelets. Circulatory shock. 1987 Academic Article GET IT
Times cited: 1
Phospholipase C-diglyceride lipase is a major pathway for arachidonic acid release in macrophages. Biochemical and biophysical research communications. 1986 Academic Article GET IT
Times cited: 27
Membrane fluidity and thromboxane synthesis in platelets from patients with severe atherosclerosis. Thrombosis research. 1986 Academic Article GET IT
Times cited: 12
Arachidonic acid releasing systems in pig aorta endothelial cells. Biochemical and biophysical research communications. 1986 Academic Article GET IT
Times cited: 8
Ionophore A23187 induces a refractory state in thrombin-activated release of inositol phosphates. The Biochemical journal. 1986 Academic Article GET IT
Intracellular Ca2+ requirements for zymosan-stimulated phosphoinositide hydrolysis in mouse peritoneal macrophages. Biochemical and biophysical research communications. 1986 Academic Article GET IT
Times cited: 8
The fluidity of liver plasma membranes from patients with different types of liver injury. Hepatology (Baltimore, Md.). 1986 Academic Article GET IT
Times cited: 33
Functional properties of isolated hepatocytes from ethanol-treated rat liver. Hepatology (Baltimore, Md.). 1985 Academic Article GET IT
Times cited: 12
The fluidity of plasma membranes from ethanol-treated rat liver. Molecular and cellular biochemistry. 1984 Academic Article GET IT
Times cited: 31

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Research

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Funding awarded

Cholesterol Metabolism in Mesenchymal Colorectal Cancer awarded by National Cancer Institute Principal Investigator 2022 - 2027
Interferon regulation by NBR1-driven chaperone-mediated autophagy in stellate cells in liver cancer awarded by National Cancer Institute Principal Investigator 2021 - 2026
Molecular mechanisms driving mesenchymal colorectal cancer awarded by National Cancer Institute Principal Investigator 2021 - 2026
Addgene 698073 awarded by Addgene, Inc. Principal Investigator 2022 - 2023
Addgene 700828 awarded by Addgene, Inc. Principal Investigator 2022 - 2023

Novel Pathways in the Control of Lineage Plasticity in Neuroendocrine Prostate Cancer awarded by National Cancer Institute Co-Investigator 2020 - 2025

Role of p62/SQSTM1 in obesity-induced liver cancer awarded by National Cancer Institute Principal Investigator Subaward 2020 - 2022

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Background

education and training

Ph.D., Complutense University of Madrid (Spain) 1984
B.S., Complutense University of Madrid (Spain) 1980

Contact

full name

Jorge Moscat

VIVO Weill Cornell Medical College

Jorge Moscat Professor of Pathology and Laboratory Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name