Molecular pathways regulating mobilization of marrow-derived stem cells for tissue revascularization. Review uri icon

Overview

abstract

  • Adult bone marrow is a rich reservoir of hematopoietic and vascular stem and progenitor cells. Mobilization and recruitment of these cells are essential for tissue revascularization. Physiological stress, secondary to tissue injury or tumor growth, results in the release of angiogenic factors, including vascular endothelial growth factor (VEGF), which promotes mobilization of stem cells to the circulation, contributing to the formation of functional vasculature. VEGF interacts with its receptors, VEGFR2 and VEGFR1, expressed on endothelial and hematopoietic stem cells, and thereby promotes recruitment of these cells to neo-angiogenic sites, accelerating the revascularization process. The mobilization of stem cells from marrow is a dynamic process, regulated by shear stress imparted by blood flow, and the activation of metalloproteinases that induce the release of 'Kit ligand', facilitating egress from the marrow to the circulation. Identification of the molecular pathways that support the proliferation and differentiation of vascular stem and progenitor cells will open up new avenues for the design of clinical trials to accelerate tissue vascularization and organogenesis.

publication date

  • March 1, 2003

Research

keywords

  • Hematopoietic Stem Cells
  • Neovascularization, Physiologic

Identity

Scopus Document Identifier

  • 0037358570

Digital Object Identifier (DOI)

  • 10.1016/s1471-4914(03)00021-2

PubMed ID

  • 12657432

Additional Document Info

volume

  • 9

issue

  • 3