The clinically available NMDA receptor antagonist dextromethorphan attenuates acute morphine withdrawal in the neonatal rat. Academic Article uri icon

Overview

abstract

  • We investigated the ability of dextromethorphan, a clinically available NMDA receptor antagonist, to attenuate the behaviors and the expression of c-fos mRNA associated with acute morphine withdrawal in the 7-day-old rat. The intensity of the acute morphine withdrawal behaviors and the elevation in c-fos mRNA expression in the brain induced by acute morphine withdrawal were reduced by dextromethorphan. Thus, dextromethorphan can attenuate acute morphine withdrawal in the developing organism.

publication date

  • May 14, 2003

Research

keywords

  • Brain
  • Dextromethorphan
  • Excitatory Amino Acid Antagonists
  • Morphine Dependence
  • Neurons
  • Receptors, N-Methyl-D-Aspartate
  • Substance Withdrawal Syndrome

Identity

Scopus Document Identifier

  • 0037616431

Digital Object Identifier (DOI)

  • 10.1016/s0165-3806(03)00059-2

PubMed ID

  • 12711372

Additional Document Info

volume

  • 142

issue

  • 2