Inturrisi, Charles E.

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Comment on "Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status". CNS drugs. 2022 Letter GET IT
Times cited: 3
REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial. The American journal of psychiatry. 2021 Academic Article GET IT
Times cited: 29
The effect of obesity on pain severity and pain interference. Pain management. 2021 Academic Article GET IT
Times cited: 4
Understanding Opioid Actions, Pain and Analgesia: A Tribute to Dr. Gavril Pasternak. Cellular and molecular neurobiology. 2021 Editorial Article GET IT
REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study. Frontiers in pharmacology. 2021 Academic Article GET IT
Times cited: 82
Successful use of buprenorphine-naloxone medication-assisted program to treat concurrent pain and opioid addiction after cancer therapy. Journal of opioid management. 2020 Academic Article GET IT
Times cited: 4
Does transdermal fentanyl work in patients with low BMI? Patient-reported outcomes of pain and percent pain relief in cancer patients on transdermal fentanyl. Cancer medicine. 2019 Academic Article GET IT
Times cited: 2
The N-methyl-D-aspartate receptor antagonist d-methadone acutely improves depressive-like behavior in the forced swim test performance of rats. Experimental and clinical psychopharmacology. 2019 Academic Article GET IT
Times cited: 15
Characterization of the Safety and Pharmacokinetic Profile of D-Methadone, a Novel N-Methyl-D-Aspartate Receptor Antagonist in Healthy, Opioid-Naive Subjects: Results of Two Phase 1 Studies. Journal of clinical psychopharmacology. 2019 Academic Article GET IT
Times cited: 19
The Tri-Institutional Pain Registry-Analysis of Outpatient Pain Management at a Specialized Cancer Center. Pain medicine (Malden, Mass.). 2017 Academic Article GET IT
Times cited: 6
Patient-Reported Outcomes and Opioid Use by Outpatient Cancer Patients. The journal of pain. 2017 Academic Article GET IT
Times cited: 18
Patient-Reported Outcomes and Opioid Use in Outpatients With Chronic Pain. The journal of pain. 2017 Academic Article GET IT
Times cited: 7
Pain Assessment, Management, and Control Among Patients 65 Years or Older Receiving Hospice Care in the U.S. Journal of pain and symptom management. 2016 Academic Article GET IT
Times cited: 15
Using Chronic Pain Outcomes Data to Improve Outcomes. Anesthesiology clinics. 2016 Review GET IT
Times cited: 5
Methadone safety: a clinical practice guideline from the American Pain Society and College on Problems of Drug Dependence, in collaboration with the Heart Rhythm Society. 2014 GET IT
Times cited: 176
Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 47
Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges. The journal of pain. 2013 Review GET IT
Times cited: 89
Cav1.2 L-type Ca²⁺ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Academic Article GET IT
Times cited: 70
Improving the pharmacologic management of pain in older adults: identifying the research gaps and methods to address them. Pain medicine (Malden, Mass.). 2011 Conference Paper GET IT
Times cited: 85
A true believer's flawed analysis. Archives of internal medicine. 2011 Letter GET IT
Times cited: 6
Estradiol-induced antinociceptive responses on formalin-induced nociception are independent of COX and HPA activation. Synapse (New York, N.Y.). 2011 Academic Article GET IT
Times cited: 13
Interactions of estradiol and NSAIDS on carrageenan-induced hyperalgesia. Brain research. 2011 Academic Article GET IT
Times cited: 9
Opioid pharmacotherapy for chronic non-cancer pain in the United States: a research guideline for developing an evidence-base. 2010 GET IT
Times cited: 142
Spinal mediators that may contribute selectively to antinociceptive tolerance but not other effects of morphine as revealed by deletion of GluR5. Neuroscience. 2010 Academic Article GET IT
Times cited: 5
N-Methyl-D-aspartate receptor (NMDAR) independent maintenance of inflammatory pain. Pain. 2009 Academic Article GET IT
Times cited: 49
Deletion of the GluR5 subunit of kainate receptors affects cocaine sensitivity and preference. Neuroscience letters. 2009 Academic Article GET IT
Times cited: 3
The contribution of MOR-1 exons 1-4 to morphine and heroin analgesia and dependence. Neuroscience letters. 2009 Academic Article GET IT
Times cited: 14
siRNA-mediated knockdown of the NR1 subunit gene of the NMDA receptor attenuates formalin-induced pain behaviors in adult rats. The journal of pain. 2009 Academic Article GET IT
Times cited: 45
Activation of the neuronal extracellular signal-regulated kinase 2 in the spinal cord dorsal horn is required for complete Freund's adjuvant-induced pain hypersensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Academic Article GET IT
Times cited: 53
Deletion of the glutamate receptor 5 subunit of kainate receptors affects the development of morphine tolerance. The Journal of pharmacology and experimental therapeutics. 2008 Academic Article GET IT
Times cited: 14
Inflammatory pain-induced signaling events following a conditional deletion of the N-methyl-D-aspartate receptor in spinal cord dorsal horn. Neuroscience. 2008 Academic Article GET IT
Times cited: 44
Consensus guideline on parenteral methadone use in pain and palliative care. Palliative & supportive care. 2008 Review GET IT
Times cited: 61
Conditional deletion of the NMDA-NR1 receptor subunit gene in the central nucleus of the amygdala inhibits naloxone-induced conditioned place aversion in morphine-dependent mice. Experimental neurology. 2008 Academic Article GET IT
Times cited: 31
National Institutes of Health Consensus Development Conference statement: hydroxyurea treatment for sickle cell disease. Annals of internal medicine. 2008 Conference Paper GET IT
Times cited: 205
A survey of acute and chronic heroin dependence in ten inbred mouse strains: evidence of genetic correlation with morphine dependence. Pharmacology, biochemistry, and behavior. 2008 Academic Article GET IT
Times cited: 14
Perioperative pain management in the opioid-tolerant individual. The journal of pain. 2008 Review GET IT
Times cited: 13
Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors. European journal of pharmacology. 2008 Academic Article GET IT
Times cited: 20
NIH consensus development statement on hydroxyurea treatment for sickle cell disease. NIH consensus and state-of-the-science statements. 2008 Conference Paper GET IT
Times cited: 21
The successful use of parenteral methadone in a patient with a prolonged QTc interval. 2007 GET IT
Times cited: 14
Design and evaluation of small interfering RNAs that target expression of the N-methyl-D-aspartate receptor NR1 subunit gene in the spinal cord dorsal horn. The Journal of pharmacology and experimental therapeutics. 2007 Academic Article GET IT
Times cited: 39
Estradiol replacement in ovariectomized rats is antihyperalgesic in the formalin test. The journal of pain. 2006 Academic Article GET IT
Times cited: 79
Feeling pain? Who's your daddy... Nature medicine. 2006 Comment GET IT
Times cited: 7
Pharmacokinetics and effects of 17beta-estradiol and progesterone implants in ovariectomized rats. The journal of pain. 2005 Academic Article GET IT
Times cited: 57
Estradiol and progesterone differentially regulate formalin-induced nociception in ovariectomized female rats. Hormones and behavior. 2005 Academic Article GET IT
Times cited: 73
Pharmacology of methadone and its isomers. Minerva anestesiologica. 2005 Review GET IT
Times cited: 92
The role of N-methyl-D-aspartate (NMDA) receptors in pain and morphine tolerance. Minerva anestesiologica. 2005 Review GET IT
Times cited: 37
An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance. The Journal of pharmacology and experimental therapeutics. 2004 Academic Article GET IT
Times cited: 46
MK-801 attenuates cocaine induction of c-fos and preprodynorphin mRNA levels in Fischer rats. Brain research. Molecular brain research. 2003 Academic Article GET IT
Times cited: 8
Parenteral methadone: an essential medication for the treatment of pain. Journal of pain and symptom management. 2003 Letter GET IT
Times cited: 12
A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Academic Article GET IT
Times cited: 164
Region-specific changes in NMDA receptor mRNA induced by chronic morphine treatment are prevented by the co-administration of the competitive NMDA receptor antagonist LY274614. Brain research. Molecular brain research. 2003 Academic Article GET IT
Times cited: 31
The clinically available NMDA receptor antagonist dextromethorphan attenuates acute morphine withdrawal in the neonatal rat. Brain research. Developmental brain research. 2003 Academic Article GET IT
Times cited: 13
Chronic opioid exposure produces increased heroin self-administration in rats. Pharmacology, biochemistry, and behavior. 2003 Academic Article GET IT
Times cited: 25
Attenuation of acute morphine withdrawal in the neonatal rat by the competitive NMDA receptor antagonist LY235959. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2002 Academic Article GET IT
Times cited: 16
Retinoic acid regulation of mu opioid receptor and c-fos mRNAs and AP-1 DNA binding in SH-SY5Y neuroblastoma cells. Brain research. Molecular brain research. 2002 Academic Article GET IT
Times cited: 22
Clinical pharmacology of opioids for pain. The Clinical journal of pain. 2002 Review GET IT
Times cited: 463
Possible mechanisms for the effects of botulinum toxin on pain. The Clinical journal of pain. 2002 Review GET IT
Times cited: 105
Attenuation of hyperalgesia by LY235959, a competitive N-methyl-D-aspartate receptor antagonist. Brain research. 2001 Academic Article GET IT
Times cited: 18
Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine. Pain. 1999 Academic Article GET IT
Times cited: 78
d-Methadone blocks morphine tolerance and N-methyl-D-aspartate-induced hyperalgesia. The Journal of pharmacology and experimental therapeutics. 1999 Academic Article GET IT
Times cited: 219
Transdermal fentanyl in children with cancer pain: feasibility, tolerability, and pharmacokinetic correlates. The Journal of pediatrics. 1999 Academic Article GET IT
Times cited: 85
Mu and delta opioid receptor analgesia, binding density, and mRNA levels in mice selectively bred for high and low analgesia. Brain research. 1999 Academic Article GET IT
Times cited: 35
Acute morphine dependence in mice selectively-bred for high and low analgesia. Neuroscience letters. 1998 Academic Article GET IT
Times cited: 9
Differences in delta opioid receptor antinociception, binding, and mRNA levels between BALB/c and CXBK mice. Brain research. 1998 Academic Article GET IT
Times cited: 12
Chronic naltrexone differentially affects supraspinal delta-opioid receptor-mediated antinociception. European journal of pharmacology. 1998 Academic Article GET IT
Times cited: 9
The effects of LY293558, an AMPA receptor antagonist, on acute and chronic morphine dependence. Brain research. 1997 Academic Article GET IT
Times cited: 55
The competitive alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist LY293558 attenuates and reverses analgesic tolerance to morphine but not to delta or kappa opioids. The Journal of pharmacology and experimental therapeutics. 1997 Academic Article GET IT
Times cited: 45
d-Methadone is antinociceptive in the rat formalin test. The Journal of pharmacology and experimental therapeutics. 1997 Academic Article GET IT
Times cited: 69
Gabapentin enhances the antinociceptive effects of spinal morphine in the rat tail-flick test. Pain. 1997 Academic Article GET IT
Times cited: 100
Effect of supraspinal antisense oligodeoxynucleotide treatment on delta-opioid receptor mRNA levels in mice. Brain research. Molecular brain research. 1997 Academic Article GET IT
Times cited: 6
Inducible expression of N-methyl-D-aspartate receptor, and delta and mu opioid receptor messenger RNAs and protein in the NT2-N human cell line. Neuroscience. 1997 Academic Article GET IT
Times cited: 15
Activation of protein kinase A prevents the ethanol-induced up-regulation of delta-opioid receptor mRNA in NG108-15 cells. Brain research. Molecular brain research. 1997 Academic Article GET IT
Times cited: 11
Estrogen regulation of mu-opioid receptor mRNA in the forebrain of female rats. Brain research. Molecular brain research. 1997 Academic Article GET IT
Times cited: 82
The d- and l-isomers of methadone bind to the non-competitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord. Neuroscience letters. 1997 Academic Article GET IT
Times cited: 316
Spinal gabapentin is antinociceptive in the rat formalin test. Neuroscience letters. 1997 Academic Article GET IT
Times cited: 121
Blockade of morphine supersensitivity by an antisense oligodeoxynucleotide targeting the delta opioid receptor (DOR-1). Life sciences. 1997 Academic Article GET IT
Times cited: 6
Detection of delta opioid receptor and N-methyl-D-aspartate receptor-like immunoreactivity in retinoic acid-differentiated neuroblastoma x glioma (NG108-15) cells. Journal of neuroscience research. 1997 Academic Article GET IT
Times cited: 10
Oral ketamine produces a dose-dependent CNS depression in the rat. Life sciences. 1997 Academic Article GET IT
Times cited: 21
Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice. Pain. 1996 Academic Article GET IT
Times cited: 102
Ketamine attenuates and reverses morphine tolerance in rodents. Anesthesiology. 1996 Academic Article GET IT
Times cited: 119
An antisense oligodeoxynucleotide to the delta opioid receptor (DOR-1) inhibits morphine tolerance and acute dependence in mice. Brain research bulletin. 1996 Academic Article GET IT
Times cited: 110
Cerebrospinal fluid distribution of opioids after intraventricular & lumbar subarachnoid administration in sheep. Life sciences. 1996 Academic Article GET IT
Times cited: 24
Retinoic acid-induced increase in delta-opioid receptor and N-methyl-D-aspartate receptor mRNA levels in neuroblastoma x glioma (NG108-15) cells. Brain research bulletin. 1996 Academic Article GET IT
Times cited: 23
The effect of the irreversible mu-opioid receptor antagonist clocinnamox on morphine potency, receptor binding and receptor mRNA. European journal of pharmacology. 1995 Academic Article GET IT
Times cited: 24
Dextromethorphan shows efficacy in experimental pain (nociception) and opioid tolerance. Neurology. 1995 Academic Article GET IT
Times cited: 21
N-methyl-D-aspartate (NMDA) receptors, mu and kappa opioid tolerance, and perspectives on new analgesic drug development. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 1995 Review GET IT
Times cited: 118
Antisense oligodeoxynucleotides to the cloned delta receptor DOR-1: uptake, stability, and regulation of gene expression. Journal of neurochemistry. 1995 Academic Article GET IT
Times cited: 36
Assessment of delta opioid antinociception and receptor mRNA levels in mouse after chronic naltrexone treatment. Brain research. 1995 Academic Article GET IT
Times cited: 22
Ultrastructural immunolabeling shows prominent presynaptic vesicular localization of delta-opioid receptor within both enkephalin- and nonenkephalin-containing axon terminals in the superficial layers of the rat cervical spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1995 Academic Article GET IT
Times cited: 142
Differential regulation of c-fos, proenkephalin and tyrosine hydroxylase gene expression by metrazole in the hamster adrenal and hippocampus. Neuroscience letters. 1995 Academic Article GET IT
Custom-made capsules and suppositories of methadone for patients on high-dose opioids for cancer pain. Pain. 1995 Academic Article GET IT
Times cited: 101
Dextromethorphan suppresses both formalin-induced nociceptive behavior and the formalin-induced increase in spinal cord c-fos mRNA. Pain. 1995 Academic Article GET IT
Times cited: 66
Proenkephalin gene expression: interaction of glucocorticoid and cAMP regulatory elements. Biochemical and biophysical research communications. 1995 Academic Article GET IT
Times cited: 10
NMDA antagonists and clonidine block c-fos expression during morphine withdrawal. Synapse (New York, N.Y.). 1995 Academic Article GET IT
Times cited: 42
Morphine-6-glucuronide concentrations and opioid-related side effects: a survey in cancer patients. Pain. 1995 Academic Article GET IT
Times cited: 136
Quantitation of mu-opioid receptor (MOR-1) mRNA in selected regions of the rat CNS. Neuroreport. 1995 Academic Article GET IT
Times cited: 25
CNS levels of mu opioid receptor (MOR-1) mRNA during chronic treatment with morphine or naltrexone. Brain research bulletin. 1995 Academic Article GET IT
Times cited: 54
Quantitative distribution of the delta opioid receptor mRNA in the mouse and rat CNS. Life sciences. 1995 Academic Article GET IT
Times cited: 26
Supraspinal delta opioid receptor mRNA levels are not altered in [D-Ala2]deltorphin II tolerant mice. Journal of neuroscience research. 1994 Academic Article GET IT
Times cited: 17
Dextromethorphan attenuates and reverses analgesic tolerance to morphine. Pain. 1994 Academic Article GET IT
Times cited: 122
Ethanol and naloxone differentially upregulate delta opioid receptor gene expression in neuroblastoma hybrid (NG108-15) cells. Brain research. Molecular brain research. 1994 Academic Article GET IT
Times cited: 30
Nitric oxide and opioid tolerance. Neuropharmacology. 1994 Academic Article GET IT
Times cited: 115
An improved method detects differential NGF and BDNF gene expression in response to depolarization in cultured hippocampal neurons. Brain research. Molecular brain research. 1994 Academic Article GET IT
Times cited: 27
Acute and persistent suppression of preproenkephalin mRNA expression in the striatum following developmental hypoxic-ischemic injury. Journal of neurochemistry. 1994 Academic Article GET IT
Times cited: 27
Prolonged tolerance, dependence and abstinence following subcutaneous morphine pellet implantation in the rat. European journal of pharmacology. 1994 Academic Article GET IT
Times cited: 120
Cloning and characterization of hamster proenkephalin gene. DNA and cell biology. 1994 Academic Article GET IT
Times cited: 16
Modulation of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist LY274614: assessment of opioid receptor changes. The Journal of pharmacology and experimental therapeutics. 1994 Academic Article GET IT
Times cited: 93
The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids. Pain. 1994 Academic Article GET IT
Times cited: 252
Metrazole induction of c-fos and proenkephalin gene expression in the rat adrenal and hippocampus: pharmacological characterization. Brain research. Molecular brain research. 1993 Academic Article GET IT
Times cited: 15
Metrazole induces the sequential activation of c-fos, proenkephalin, and tyrosine hydroxylase gene expression in the rat adrenal gland: modulation by glucocorticoid and adrenocorticotropic hormone. Molecular pharmacology. 1993 Academic Article GET IT
Times cited: 18
Quantitation of NMDA receptor (NMDAR1) mRNA levels in the adult and developing rat CNS. Brain research. Molecular brain research. 1993 Academic Article GET IT
Times cited: 48
Induction of tyrosine hydroxylase mRNA by protein synthesis inhibitors in the rat adrenal. Molecular and cellular neurosciences. 1993 Academic Article GET IT
Times cited: 5
Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions. Nature. 1993 Academic Article GET IT
Times cited: 351
Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614. The Journal of pharmacology and experimental therapeutics. 1993 Academic Article GET IT
Times cited: 210
Naltrexone Maintenance: Effect on Morphine Sensitivity in Normal Volunteers. The American journal on addictions. 1993 Academic Article GET IT
Quantitation of the levels of tyrosine hydroxylase and preproenkephalin mRNAs in nigrostriatal sites after 6-hydroxydopamine lesions. Life sciences. 1993 Academic Article GET IT
Times cited: 11
Transdermal fentanyl for cancer pain. Repeated dose pharmacokinetics. Anesthesiology. 1993 Academic Article GET IT
Times cited: 169
Effect of adrenal and sex hormones on opioid analgesia and opioid receptor regulation. Pharmacology, biochemistry, and behavior. 1992 Academic Article GET IT
Times cited: 101
Treatment of opioid-induced constipation with oral naloxone: a pilot study. 1992 GET IT
Times cited: 173
The metabolite morphine-6-glucuronide contributes to the analgesia produced by morphine infusion in patients with pain and normal renal function. Clinical pharmacology and therapeutics. 1992 Academic Article GET IT
Times cited: 117
Time course of enkephalin mRNA and peptides in cultured rat adrenal medulla. Brain research. Molecular brain research. 1992 Academic Article GET IT
Times cited: 51
Plasma morphine and morphine-6-glucuronide during chronic morphine therapy for cancer pain: plasma profiles, steady-state concentrations and the consequences of renal failure. Pain. 1991 Academic Article GET IT
Times cited: 115
Transsynaptic activity regulates proenkephalin and tyrosine hydroxylase gene expression and the response to reserpine in the hamster adrenal. Molecular pharmacology. 1991 Academic Article GET IT
Times cited: 16
Chronic morphine therapy for cancer pain: plasma and cerebrospinal fluid morphine and morphine-6-glucuronide concentrations. Neurology. 1991 Academic Article GET IT
Times cited: 53
Preproenkephalin mRNA and enkephalin in normal and denervated adrenals in the Syrian hamster: comparison with central nervous system tissues. Brain research. Molecular brain research. 1991 Academic Article GET IT
Times cited: 32
Chronic nausea and morphine-6-glucuronide. 1991 GET IT
Times cited: 103
The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions. 1990 GET IT
Times cited: 533
Effect of pregnancy and pain on cerebrospinal fluid immunoreactive enkephalins and norepinephrine in healthy humans. Pain. 1990 Academic Article GET IT
Times cited: 16
Principles of analgesic use in the treatment of acute pain and chronic cancer pain, 2nd edition. American Pain Society. Clinical pharmacy. 1990 Review GET IT
Times cited: 47
Pharmacokinetic-pharmacodynamic relationships of methadone infusions in patients with cancer pain. Clinical pharmacology and therapeutics. 1990 Academic Article GET IT
Times cited: 98
Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite. The Journal of pharmacology and experimental therapeutics. 1989 Academic Article GET IT
Times cited: 354
Management of cancer pain. Pharmacology and principles of management. Cancer. 1989 Review GET IT
Times cited: 47
Opioid receptor upregulation and supersensitivity in mice: effect of morphine sensitivity. Pharmacology, biochemistry, and behavior. 1989 Academic Article GET IT
Times cited: 31
Sublingual absorption of selected opioid analgesics. Clinical pharmacology and therapeutics. 1988 Academic Article GET IT
Times cited: 221
Glucocorticoid regulation of enkephalins in cultured rat adrenal medulla. Molecular endocrinology (Baltimore, Md.). 1988 Academic Article GET IT
Times cited: 60
Characterization of enkephalins in rat adrenal medullary explants. Brain research. 1988 Academic Article GET IT
Times cited: 18
Morphine-induced immunomodulation is not related to serum morphine concentrations. European journal of pharmacology. 1988 Academic Article GET IT
Times cited: 62
Adrenal enkephalin biosynthesis regulated by glucocorticoid. NIDA research monograph. 1988 Academic Article GET IT
Times cited: 2
Modification of the response to opioid and nonopioid drugs by chronic opioid antagonist treatment. Life sciences. 1988 Academic Article GET IT
Times cited: 34
Upregulation of opioid receptor subtypes correlates with potency changes of morphine and DADLE. Life sciences. 1988 Academic Article GET IT
Times cited: 52
Morphine-6-glucuronide, a potent mu agonist. Life sciences. 1987 Academic Article GET IT
Times cited: 342
High-dose naloxone: pharmacokinetics in patients in septic shock. Critical care medicine. 1987 Academic Article GET IT
Times cited: 22
Chronic opioid antagonist treatment facilitates nonopioid, stress-induced analgesia. Pharmacology, biochemistry, and behavior. 1987 Academic Article GET IT
Times cited: 20
Principles of analgesic use in the treatment of acute pain or chronic cancer pain. American Pain Society. Clinical pharmacy. 1987 Review GET IT
Times cited: 12
Regulation of rat adrenal medullary enkephalins by glucocorticoids. Life sciences. 1987 Academic Article GET IT
Times cited: 30
Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain. Clinical pharmacology and therapeutics. 1987 Academic Article GET IT
Times cited: 224
Analgesic drug therapy in cancer pain: principles and practice. The Medical clinics of North America. 1987 Review GET IT
Times cited: 73
A comparison of the effects of a macrobiotic diet and a Western diet on drug metabolism and plasma lipids in man. European journal of clinical pharmacology. 1987 Academic Article GET IT
Times cited: 12
A chronic sheep preparation for the study of drug pharmacokinetics in spinal and ventricular CSF. Journal of pharmacological methods. 1986 Academic Article GET IT
Times cited: 14
Pharmacodynamic supersensitivity and opioid receptor upregulation in the mouse. The Journal of pharmacology and experimental therapeutics. 1986 Academic Article GET IT
Times cited: 73
Cerebrospinal fluid pharmacokinetics of intrathecal morphine sulfate and D-Ala2-D-Leu5-enkephalin. Annals of neurology. 1986 Academic Article GET IT
Times cited: 19
I.v. infusion of opioids for cancer pain: clinical review and guidelines for use. Cancer treatment reports. 1986 Academic Article GET IT
Times cited: 86
Pharmacokinetics and pharmacodynamics of subcutaneous naltrexone pellets in the rat. The Journal of pharmacology and experimental therapeutics. 1986 Academic Article GET IT
Times cited: 59
Influence of naloxone infusion on analgesia and respiratory depression following epidural morphine. Anesthesiology. 1986 Academic Article GET IT
Times cited: 94
Epidural and intrathecal opiates: cerebrospinal fluid and plasma profiles in patients with chronic cancer pain. Clinical pharmacology and therapeutics. 1985 Academic Article GET IT
Times cited: 81
Pharmacokinetics and pharmacodynamics of subcutaneous morphine pellets in the rat. The Journal of pharmacology and experimental therapeutics. 1985 Academic Article GET IT
Times cited: 89
The analgesic efficacy of intrathecal D-Ala2-D-Leu5-enkephalin in cancer patients with chronic pain. Pain. 1985 Academic Article GET IT
Times cited: 56
CSF distribution of morphine, methadone and sucrose after intrathecal injection. Life sciences. 1985 Academic Article GET IT
Times cited: 51
Increased analgesic potency of morphine and increased brain opioid binding sites in the rat following chronic naltrexone treatment. Life sciences. 1985 Academic Article GET IT
Times cited: 72
The graded and quantal nature of opioid analgesia in the rat tailflick assay. Brain research. 1985 Academic Article GET IT
Times cited: 17
D-Propoxyphene: accumulation or altered kinetics?. European journal of clinical pharmacology. 1985 Letter GET IT
Times cited: 1
Role of opioid analgesics. The American journal of medicine. 1984 Academic Article GET IT
Times cited: 27
Chronic vascular catheterization in the rat: comparison of three techniques. Physiology & behavior. 1984 Academic Article GET IT
Times cited: 50
The pharmacokinetics of heroin in patients with chronic pain. The New England journal of medicine. 1984 Academic Article GET IT
Times cited: 200
Constraints on the tailflick assay: morphine analgesia and tolerance are dependent upon locus of tail stimulation. Life sciences. 1984 Academic Article GET IT
Times cited: 48
Methadone induced physical dependence in the rat. Life sciences. 1984 Academic Article GET IT
Times cited: 25
Effects of eight-hour naloxone infusions on human subjects. Biological psychiatry. 1983 Academic Article GET IT
Times cited: 38
Naloxone radioimmunoassay: an improved antiserum. The Journal of pharmacy and pharmacology. 1983 Academic Article GET IT
Times cited: 20
Methadyl acetate (LAAM) in the treatment of heroin addicts. II. Double-blind comparison of gradual and abrupt detoxification. Archives of general psychiatry. 1983 Academic Article GET IT
Times cited: 20
Beta-endorphin immunoreactivity in the plasma of patients with the Prader-Labhart-Willi syndrome and their normal siblings. Experientia. 1983 Academic Article GET IT
Times cited: 7
Levorphanol: pharmacokinetics and steady-state plasma concentrations in patients with pain. Research communications in chemical pathology and pharmacology. 1983 Academic Article GET IT
Times cited: 32
Central nervous system excitatory effects of meperidine in cancer patients. Annals of neurology. 1983 Academic Article GET IT
Times cited: 339
Plasma immunoreactive beta-endorphin levels in depression. Effect of electroconvulsive therapy. Archives of general psychiatry. 1983 Academic Article GET IT
Times cited: 45
Evidence from opiate binding studies that heroin acts through its metabolites. Life sciences. 1983 Academic Article GET IT
Times cited: 169
Determination of heroin and its metabolites by high-performance liquid chromatography. Journal of chromatography. 1982 Academic Article GET IT
Times cited: 48
Heroin: analgesia, toxicity and disposition in the mouse. European journal of pharmacology. 1982 Academic Article GET IT
Times cited: 28
Antinociceptive activity and toxicity of meperidine and normeperidine in mice. The Journal of pharmacology and experimental therapeutics. 1982 Academic Article GET IT
Times cited: 33
Narcotic drugs. The Medical clinics of North America. 1982 Academic Article GET IT
Times cited: 11
Propoxyphene and norpropoxyphene kinetics after single and repeated doses of propoxyphene. Clinical pharmacology and therapeutics. 1982 Academic Article GET IT
Times cited: 46
beta-Endorphin immunoreactivity in the plasma of psychiatric patients receiving electroconvulsive treatment. Annals of the New York Academy of Sciences. 1982 Academic Article GET IT
Times cited: 29
Pharmacodynamics of subcutaneously administered diacetylmorphine, 6-acetylmorphine and morphine in mice. The Journal of pharmacology and experimental therapeutics. 1981 Academic Article GET IT
Times cited: 114
Pituitary metastasis: incidence in cancer patients and clinical differentiation from pituitary adenoma. 1981 GET IT
Times cited: 217
Levorphanol: a simplified radioimmunoassay for clinical use. Research communications in chemical pathology and pharmacology. 1981 Academic Article GET IT
Times cited: 6
Disposition of methadone in the ovine maternal-fetal unit. Life sciences. 1981 Academic Article GET IT
Times cited: 15
Methadone: radioimmunoassay and pharmacokinetics in the rat. The Journal of pharmacology and experimental therapeutics. 1981 Academic Article GET IT
Times cited: 53
Determination of acetylmethadol and metabolites by use of high-performance liquid chromatography. Journal of chromatography. 1981 Academic Article GET IT
Times cited: 8
Brain uptake of meperidine in the fetal lamb. American journal of obstetrics and gynecology. 1980 Academic Article GET IT
Times cited: 10
Analgesic activity of the naturally occurring heptapeptide [Met]enkephalin-Arg6-Phe7. Proceedings of the National Academy of Sciences of the United States of America. 1980 Academic Article GET IT
Times cited: 76
Levorphanol:radioimmunoassay and plasma concentration profiles in dog and man. Research communications in chemical pathology and pharmacology. 1980 Academic Article GET IT
Times cited: 7
Intrathecal beta-endorphin. Lancet (London, England). 1980 Letter GET IT
Times cited: 2
Renal tubular secretion of meperidine by the fetal lamb. The Journal of pharmacology and experimental therapeutics. 1980 Academic Article GET IT
Times cited: 8
Analgesia produced by a spinal action of morphine and effects upon parturition in the rat. Anesthesiology. 1979 Academic Article GET IT
Times cited: 37
beta-Endorphin: analgesic and hormonal effects in humans. Proceedings of the National Academy of Sciences of the United States of America. 1979 Academic Article GET IT
Times cited: 175
Urinary excretion of meperidine by the fetal lamb. The Journal of pharmacology and experimental therapeutics. 1979 Academic Article GET IT
Times cited: 10
Meperidine pharmacokinetics in the maternal-fetal unit. The Journal of pharmacology and experimental therapeutics. 1978 Academic Article GET IT
Times cited: 33
Amniotic fluid transfer of meperidine from maternal plasma in early pregnancy. Obstetrics and gynecology. 1978 Academic Article GET IT
Times cited: 14
Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer. 1977 GET IT
Times cited: 274
Combined seminar on the use of drugs in renal failure: narcotics, psychotherapeutic agents, antiarrhythmics, antihypertensives, sorbents, vitamin D and its analogues, anabolic hormones and nutritional supplements. The American journal of medicine. 1977 Academic Article GET IT
Times cited: 4
Disposition of narcotics in patients with renal disease. The American journal of medicine. 1977 Academic Article GET IT
Times cited: 8
Reduction of 6-ketones of the morphine series with formamidinesulfinic acid. Stereoselectivity opposite to that of hydride reductions. The Journal of organic chemistry. 1976 Academic Article GET IT
Times cited: 13
Simultaneous determination of meperidine and normeperidine in biofluids. Journal of chromatography. 1976 Academic Article GET IT
Times cited: 20
Disposition of acetylmethadol in relation to pharmacological activity. 1975 [proceedings]. NIDA research monograph. 1976 Academic Article GET IT
Simultaneous determination of acetyl-methadol and its active biotransformation products in human biofluids. 1975 [proceedings]. NIDA research monograph. 1976 Academic Article GET IT
Effects of acetylmethadol on plasma testosterone. Clinical pharmacology and therapeutics. 1976 Academic Article GET IT
Times cited: 23
Disposition of narcotics and narcotic antagonists. Annals of the New York Academy of Sciences. 1976 Review GET IT
Times cited: 19
The urinary excretion profiles of naltrexone in man, monkey, rabbit, and rat. Drug metabolism and disposition: the biological fate of chemicals. 1976 Academic Article GET IT
Times cited: 30
Disposition of acetylmethadol in relation to pharmacologic action. Clinical pharmacology and therapeutics. 1975 Academic Article GET IT
Times cited: 63
Simultaneous determination of acetylmethadol and its active riotransformation products in human biofluids. Journal of chromatography. 1975 Academic Article GET IT
Times cited: 16
Synthesis of alpha-1-noracetylmethadol. A facile N-demethylation of alpha-1-acetylmethadol. Journal of medicinal chemistry. 1975 Academic Article GET IT
Times cited: 4
Stereospecific synthesis of the 6beta-hydroxy metabolites of naltrexone and naloxone. Journal of medicinal chemistry. 1975 Academic Article GET IT
Times cited: 63
Methadone assays in pregnant women and progeny. American journal of obstetrics and gynecology. 1975 Academic Article GET IT
Times cited: 92
Narcotic antagonist activity of several metabolites of naloxone and naltrexone tested in morphine dependent mice (38558). Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1975 Academic Article GET IT
Times cited: 28
The quantitation of cyclazocine and its metabolites in human urine by use of gas-liquid chromatography. Journal of chromatography. 1974 Academic Article GET IT
Times cited: 9
Disposition of propoxyphene and norpropoxyphene in man after a single oral dose. Clinical pharmacology and therapeutics. 1974 Academic Article GET IT
Times cited: 37
Amniotic fluid methadone in women maintained on methadone. The Mount Sinai journal of medicine, New York. 1974 Academic Article GET IT
Times cited: 14
Isolation and stereochemical identification of a metabolite of naltrexone from human urine. Drug metabolism and disposition: the biological fate of chemicals. 1974 Academic Article GET IT
Times cited: 31
Ouabain sensitivity of the Na+, K+-ATPase from rat neonatal and human fetal and adult heart. Annals of the New York Academy of Sciences. 1974 Academic Article GET IT
Times cited: 14
An anomalous reaction of methadone with chloroformate esters. The Journal of organic chemistry. 1973 Academic Article GET IT
Times cited: 5
A gas-liquid chromatographic method for the quantitative determination of acetylmethadol and its metabolites in human urine. Journal of chromatography. 1973 Academic Article GET IT
Times cited: 17
The quantitation of methadone in human amniotic fluid. Research communications in chemical pathology and pharmacology. 1973 Academic Article GET IT
Times cited: 9
The simultaneous determination of propoxyphene and norpropoxyphene in human biofluids using gas-liquid chromatography. Journal of chromatography. 1973 Academic Article GET IT
Times cited: 49
A gas-liquid chromatographic method for the quantitative determination of methadone in human plasma and urine. Journal of chromatography. 1972 Academic Article GET IT
Times cited: 67
Disposition of methadone in man after a single oral dose. Clinical pharmacology and therapeutics. 1972 Academic Article GET IT
Times cited: 110
The levels of methadone in the plasma in methadone maintenance. Clinical pharmacology and therapeutics. 1972 Academic Article GET IT
Times cited: 134
Ouabain-dependent incorporation of 32P from p-nitrophenyl phosphate into a microsomal phosphatase. Molecular pharmacology. 1970 Academic Article GET IT
Times cited: 28
Thallium-induced dephosphorylation of a phosphorylated intermediate of the (sodium plus thallium-activated) ATPase. Biochimica et biophysica acta. 1969 Academic Article GET IT
Times cited: 26
Thallium activation of K+-activated phosphatases from beef brain. Biochimica et biophysica acta. 1969 Academic Article GET IT
Times cited: 35
The diuretic effect of morphine in the chicken. European journal of pharmacology. 1968 Academic Article GET IT
Times cited: 6
Kinetics of oligomycin inhibition of sodium- and potassium-activated adenosine triphosphatase from beef brain. Molecular pharmacology. 1968 Academic Article GET IT
Times cited: 34
The antidiuretic effect of narcotic analgesics in the mouse. Toxicology and applied pharmacology. 1968 Academic Article GET IT
Times cited: 3
The development of tolerance to the antidiuretic effect of morphine in the mouse. Toxicology and applied pharmacology. 1968 Academic Article GET IT
Times cited: 3
Studies on the antidiuretic action of morphine in the rat. European journal of pharmacology. 1968 Academic Article GET IT
Times cited: 21
The tubular transport and metabolism of morphine-N-methyl-C14 by the chicken kidney. The Journal of pharmacology and experimental therapeutics. 1967 Academic Article GET IT
Times cited: 17
EFFECTS OF LEVORPHANOL AND LEVALLORPHAN ON OSMOLALITY OF SERUM FROM WATER LOADED RATS. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1963 Academic Article GET IT

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Funding awarded

Genetic and Environmental Influences on Addiction awarded by National Institute on Drug Abuse Key Personnel 2017 - 2023

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Background

education and training

Ph.D., Tulane University 1967
M.S., Tulane University 1965
B.A., University of Connecticut 1962

Contact

full name

Charles E. Inturrisi

primary email

ceintur@med.cornell.edu

VIVO Weill Cornell Medical College

Charles E. Inturrisi Professor of Pharmacology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email