The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1. Academic Article uri icon

Overview

abstract

  • The chemokine, stromal derived factor-1 (SDF1) has been shown to modulate the homing of stem cells to its site by mediating chemotaxis. We demontrated overexpression of SDF-1 induced mobilization of cells with stem cell potential (CFU-S, long-term reconstituting cells). Moreover, SDF-1 activated matrix metalloproteinase-9 induced in bone marrow (BM) cells, causing the release soluble Kit-ligand and permitting the transfer of hematopoietic stem cells (HSCs) from a quiescent to a proliferative niche. The role of SDF-1 in the process of HSC migration and the mechanism underlying this HSCs migration will be reviewed. These studies lay the foundation for using SDF-1 to induce mobilization of progenitor cells in a BM transplantation setting.

publication date

  • April 1, 2003

Research

keywords

  • Chemokines, CXC
  • Hematopoietic Stem Cells
  • Stem Cells

Identity

Scopus Document Identifier

  • 0037375863

Digital Object Identifier (DOI)

  • 10.1080/1042819021000037985

PubMed ID

  • 12769333

Additional Document Info

volume

  • 44

issue

  • 4