Lysosomal cysteine proteases regulate antigen presentation. Review uri icon

Overview

abstract

  • Antigen presentation by both classical MHC class II molecules and the non-classical MHC class I-like molecule CD1D requires their entry into the endosomal/lysosomal compartment. Lysosomal cysteine proteases constitute an important subset of the enzymes that are present in this compartment and, here, we discuss the role of these proteases in regulating antigen presentation by both MHC class II and CD1D molecules.

publication date

  • June 1, 2003

Research

keywords

  • Antigen Presentation
  • Cysteine Endopeptidases
  • Lymphoid Tissue
  • Lysosomes

Identity

Scopus Document Identifier

  • 0037805704

Digital Object Identifier (DOI)

  • 10.1038/nri1110

PubMed ID

  • 12776207

Additional Document Info

volume

  • 3

issue

  • 6