Identification of transcription coactivator OCA-B-dependent genes involved in antigen-dependent B cell differentiation by cDNA array analyses. Academic Article uri icon

Overview

abstract

  • The tissue-specific transcriptional coactivator OCA-B is required for antigen-dependent B cell differentiation events, including germinal center formation. However, the identity of OCA-B target genes involved in this process is unknown. This study has used large-scale cDNA arrays to monitor changes in gene expression patterns that accompany mature B cell differentiation. B cell receptor ligation alone induces many genes involved in B cell expansion, whereas B cell receptor and helper T cell costimulation induce genes associated with B cell effector function. OCA-B expression is induced by both B cell receptor ligation alone and helper T cell costimulation, suggesting that OCA-B is involved in B cell expansion as well as B cell function. Accordingly, several genes involved in cell proliferation and signaling, such as Lck, Kcnn4, Cdc37, cyclin D3, B4galt1, and Ms4a11, have been identified as OCA-B-dependent genes. Further studies on the roles played by these genes in B cells will contribute to an understanding of B cell differentiation.

publication date

  • July 11, 2003

Research

keywords

  • B-Lymphocytes
  • Potassium Channels, Calcium-Activated
  • Trans-Activators

Identity

PubMed Central ID

  • PMC166405

Scopus Document Identifier

  • 0042307365

Digital Object Identifier (DOI)

  • 10.1073/pnas.1033108100

PubMed ID

  • 12857960

Additional Document Info

volume

  • 100

issue

  • 15