ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Academic Article uri icon

Overview

abstract

  • p21c-ras plays a critical role in mediating tyrosine kinase-stimulated cell growth and differentiation. However, the pathways through which p21c-ras propagates these signals remain unknown. We report that in PC12 cells, expression of a dominant inhibitory mutant of ras, c-Ha-ras(Asn-17), antagonizes growth factor- and phorbol ester-induced activation of the erk-encoded family of MAP kinases, the 85-92 kd RSKs, and the kinase(s) responsible for hyperphosphorylation of the proto-oncogene product Raf-1. In addition, we find that expression of the activated ras oncogene is sufficient to stimulate these events. These data indicate that ras mediates nerve growth factor receptor and protein kinase C modulation of MAP kinases, RSKs, and Raf-1.

publication date

  • March 20, 1992

Research

keywords

  • Genes, Regulator
  • Genes, ras
  • Protein Kinase C
  • Protein Kinases
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins p21(ras)
  • Receptors, Cell Surface

Identity

Scopus Document Identifier

  • 0026523559

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(92)90076-o

PubMed ID

  • 1312393

Additional Document Info

volume

  • 68

issue

  • 6