Blenis, John

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An atlas of substrate specificities for the human serine/threonine kinome. Nature. 2023 Academic Article GET IT
Times cited: 19
AKTs do not translocate to the nucleus upon stimulation but AKT3 can constitutively signal from the nuclear envelope. Cell reports. 2022 Academic Article GET IT
Times cited: 1
Metabolite activation of tumorigenic signaling pathways in the tumor microenvironment. Science signaling. 2022 Review GET IT
Times cited: 5
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication. Science signaling. 2022 Academic Article GET IT
Times cited: 8
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression. Nature communications. 2022 Academic Article GET IT
Times cited: 1
Targeting mTOR in the Context of Diet and Whole-body Metabolism. Endocrinology. 2022 Review GET IT
Times cited: 1
Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells. Science advances. 2022 Academic Article GET IT
Times cited: 1
Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1. The Journal of biological chemistry. 2022 Academic Article GET IT
Times cited: 4
Altered propionate metabolism contributes to tumour progression and aggressiveness. Nature metabolism. 2022 Academic Article GET IT
Times cited: 11
Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb. Current biology : CB. 2022 Article GET IT
Times cited: 5
Glutamine deprivation triggers NAGK-dependent hexosamine salvage. eLife. 2021 Academic Article GET IT
Times cited: 17
Identification and characterization of the mediator kinase-dependent myometrial stem cell phosphoproteome. F&S science. 2021 Academic Article GET IT
Editorial Note to: Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply. Molecular cell. 2021 Editorial Article GET IT
NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma. Cell reports. 2021 Academic Article GET IT
Times cited: 13
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 2021 Academic Article GET IT
Times cited: 8
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell. 2021 Editorial Article GET IT
Times cited: 10
mTORC1 promotes cell growth via m⁶A-dependent mRNA degradation. Molecular cell. 2021 Academic Article GET IT
Times cited: 31
mTORC1-chaperonin CCT signaling regulates m⁶A RNA methylation to suppress autophagy. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
Times cited: 32
Correction for McMullen et al., "Deletion of Ribosomal S6 Kinases Does Not Attenuate Pathological, Physiological, or Insulin-Like Growth Factor 1 Receptor-Phosphoinositide 3-Kinase-Induced Cardiac Hypertrophy". Molecular and cellular biology. 2021 Academic Article GET IT
The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro. bioRxiv : the preprint server for biology. 2020 Article GET IT
Age-induced accumulation of methylmalonic acid promotes tumour progression. Nature. 2020 Academic Article GET IT
Times cited: 87
Raymond L. Erikson (1936-2020). Cell. 2020 Academic Article GET IT
Targeting the premetastatic niche: epigenetic therapies in the spotlight. Signal transduction and targeted therapy. 2020 Review GET IT
Times cited: 3
Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability. Nature communications. 2020 Academic Article GET IT
Times cited: 34
Structural Insights into the Activation of mTORC1 on the Lysosomal Surface. Trends in biochemical sciences. 2020 Comment GET IT
Times cited: 3
Histone H3 variants at the root of metastasis. Molecular & cellular oncology. 2020 Academic Article GET IT
Times cited: 270
Inhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylation. Bone. 2019 Academic Article GET IT
Times cited: 7
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Cancer cell. 2019 Academic Article GET IT
Times cited: 44
Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 15
p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration. The Journal of biological chemistry. 2019 Academic Article GET IT
Times cited: 15
Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nature cell biology. 2019 Academic Article GET IT
Times cited: 3
ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 50
Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells. Cell. 2018 Academic Article GET IT
Times cited: 56
EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC. Cancer discovery. 2018 Academic Article GET IT
Times cited: 43
Female Sex and Gender in Lung/Sleep Health and Disease. Increased Understanding of Basic Biological, Pathophysiological, and Behavioral Mechanisms Leading to Better Health for Female Patients with Lung Disease. American journal of respiratory and critical care medicine. 2018 Review GET IT
Times cited: 54
Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism?. Frontiers in cell and developmental biology. 2018 Review GET IT
Times cited: 101
mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation. Molecular cell. 2018 Academic Article GET IT
Times cited: 83
The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer. Science signaling. 2018 Academic Article GET IT
Times cited: 25
Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization. Cancer cell. 2018 Review GET IT
Times cited: 98
Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nature cell biology. 2018 Academic Article GET IT
Times cited: 887
EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer. Nature communications. 2017 Academic Article GET IT
Times cited: 17
Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. Cell. 2017 Academic Article GET IT
Times cited: 123
TOR, the Gateway to Cellular Metabolism, Cell Growth, and Disease. Cell. 2017 Academic Article GET IT
Times cited: 54
Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. Molecular cell. 2017 Academic Article GET IT
Times cited: 32
Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer. Developmental cell. 2017 Comment GET IT
Times cited: 10
The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Genes & development. 2016 Academic Article GET IT
Times cited: 80
Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis. JCI insight. 2016 Academic Article GET IT
Times cited: 4
mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress. Cancer research. 2016 Academic Article GET IT
Times cited: 20
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 188
CELL SIGNALING. Seeing mTORC1 specificity. Science (New York, N.Y.). 2016 Comment GET IT
Times cited: 3
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. Cancer discovery. 2015 Academic Article GET IT
Times cited: 255
ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate. Molecular cell. 2015 Academic Article GET IT
Times cited: 63
ERK reinforces actin polymerization to power persistent edge protrusion during motility. Science signaling. 2015 Academic Article GET IT
Times cited: 53
A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways. Current opinion in biotechnology. 2015 Review GET IT
Times cited: 61
Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 45
The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation. Current biology : CB. 2014 Academic Article GET IT
Times cited: 186
FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Autophagy. 2014 Academic Article GET IT
Times cited: 50
Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 55
Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells. Cell death & disease. 2014 Academic Article GET IT
Times cited: 37
Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 96
Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. Cell metabolism. 2014 Academic Article GET IT
Times cited: 85
Akt-ivation of RNA splicing. Molecular cell. 2014 Comment GET IT
Times cited: 5
Rapamycin: one drug, many effects. Cell metabolism. 2014 Review GET IT
Times cited: 755
Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. The Journal of experimental medicine. 2014 Academic Article GET IT
Times cited: 54
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nature cell biology. 2013 Academic Article GET IT
Times cited: 191
Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 49
AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve. Science signaling. 2013 Academic Article GET IT
Times cited: 75
Nutrient regulation of the mTOR complex 1 signaling pathway. Molecules and cells. 2013 Review GET IT
Times cited: 195
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer research. 2013 Academic Article GET IT
Times cited: 164
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 2013 Academic Article GET IT
Times cited: 445
mTORC1 signaling aids in CADalyzing pyrimidine biosynthesis. Cell metabolism. 2013 Comment GET IT
Times cited: 8
SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer cell. 2013 Academic Article GET IT
Times cited: 346
Hippo-YAP and mTOR pathways collaborate to regulate organ size. Nature cell biology. 2012 Comment GET IT
Times cited: 57
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. Molecular cell. 2012 Academic Article GET IT
Times cited: 158
TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues. FEBS letters. 2012 Academic Article GET IT
Times cited: 4
Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 47
Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 127
Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors. BMC biology. 2011 Editorial Article GET IT
Times cited: 18
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science (New York, N.Y.). 2011 Academic Article GET IT
Times cited: 670
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. Trends in biochemical sciences. 2011 Review GET IT
Times cited: 1234
ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex. Molecular cell. 2011 Academic Article GET IT
Times cited: 127
ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation. Molecular cell. 2010 Comment GET IT
Times cited: 4
ERK2/Fra1/ZEB pathway induces epithelial-to-mesenchymal transition. Cell cycle (Georgetown, Tex.). 2010 Editorial Article GET IT
Times cited: 21
A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Developmental cell. 2010 Academic Article GET IT
Times cited: 188
Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Molecular cell. 2010 Academic Article GET IT
Times cited: 209
ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. Molecular cell. 2010 Academic Article GET IT
Times cited: 241
A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique. Assay and drug development technologies. 2010 Academic Article GET IT
Times cited: 28
ERK-MAP Kinase signaling in the cytoplasm. Methods in molecular biology (Clifton, N.J.). 2010 Academic Article GET IT
Times cited: 3
Cell signaling in protein synthesis ribosome biogenesis and translation initiation and elongation. Progress in molecular biology and translational science. 2009 Review GET IT
Times cited: 61
Molecular mechanisms of mTOR-mediated translational control. Nature reviews. Molecular cell biology. 2009 Review GET IT
Times cited: 1968
p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 71
Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy. Cell cycle (Georgetown, Tex.). 2009 Review GET IT
Times cited: 176
Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-beta. Cancer research. 2009 Academic Article GET IT
Times cited: 76
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 661
The RSK family of kinases: emerging roles in cellular signalling. Nature reviews. Molecular cell biology. 2008 Review GET IT
Times cited: 578
Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 168
The RSK factors of activating the Ras/MAPK signaling cascade. Frontiers in bioscience : a journal and virtual library. 2008 Review GET IT
Times cited: 169
SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell. 2008 Academic Article GET IT
Times cited: 244
Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport. Molecular cell. 2008 Academic Article GET IT
Times cited: 64
PHLPPing it off: phosphatases get in the Akt. Molecular cell. 2007 Comment GET IT
Times cited: 34
RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. The Journal of biological chemistry. 2007 Academic Article GET IT
Times cited: 564
SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway. The Journal of biological chemistry. 2007 Academic Article GET IT
Times cited: 23
Mind the GAP: Wnt steps onto the mTORC1 train. Cell. 2006 Comment GET IT
Times cited: 31
Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development. The EMBO journal. 2006 Academic Article GET IT
Times cited: 51
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. The EMBO journal. 2006 Academic Article GET IT
Times cited: 409
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene. 2006 Academic Article GET IT
Times cited: 165
MAPK signal specificity: the right place at the right time. Trends in biochemical sciences. 2006 Review GET IT
Times cited: 567
A specific mechanomodulatory role for p38 MAPK in embryonic joint articular surface cell MEK-ERK pathway regulation. The Journal of biological chemistry. 2006 Academic Article GET IT
Times cited: 31
TORgeting oncogene addiction for cancer therapy. Cancer cell. 2006 Academic Article GET IT
Times cited: 62
Rheb activation of mTOR and S6K1 signaling. Methods in enzymology. 2006 Academic Article GET IT
Times cited: 22
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell. 2005 Academic Article GET IT
Times cited: 919
The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling. Current biology : CB. 2005 Academic Article GET IT
Times cited: 108
Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS letters. 2005 Academic Article GET IT
Times cited: 84
Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo. Current biology : CB. 2005 Academic Article GET IT
Times cited: 96
Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells. Molecular and cellular biology. 2005 Academic Article GET IT
Times cited: 88
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 285
Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nature cell biology. 2005 Academic Article GET IT
Times cited: 472
Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 46
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 183
mTOR, translational control and human disease. Seminars in cell & developmental biology. 2004 Review GET IT
Times cited: 269
SKAR is a specific target of S6 kinase 1 in cell growth control. Current biology : CB. 2004 Academic Article GET IT
Times cited: 160
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 614
Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy. Molecular and cellular biology. 2004 Academic Article GET IT
Times cited: 100
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiology and molecular biology reviews : MMBR. 2004 Review GET IT
Times cited: 1948
Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1. FEBS letters. 2004 Academic Article GET IT
Times cited: 23
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene. 2004 Review GET IT
Times cited: 1074
PI3-kinase and TOR: PIKTORing cell growth. Seminars in cell & developmental biology. 2004 Review GET IT
Times cited: 118
Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site. Molecular and cellular biology. 2004 Academic Article GET IT
Times cited: 143
A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration. Molecular and cellular biology. 2004 Academic Article GET IT
Times cited: 270
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Molecular and cellular biology. 2004 Academic Article GET IT
Times cited: 726
Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos. Journal of immunology (Baltimore, Md. : 1950). 2003 Academic Article GET IT
Times cited: 621
PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration. American journal of physiology. Cell physiology. 2003 Academic Article GET IT
Times cited: 159
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Current biology : CB. 2003 Academic Article GET IT
Times cited: 957
Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 182
Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. Molecular and cellular biology. 2003 Academic Article GET IT
Times cited: 155
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Current biology : CB. 2003 Academic Article GET IT
Times cited: 399
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proceedings of the National Academy of Sciences of the United States of America. 2002 Academic Article GET IT
Times cited: 701
Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 68
Molecular interpretation of ERK signal duration by immediate early gene products. Nature cell biology. 2002 Academic Article GET IT
Times cited: 767
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Molecular cell. 2002 Academic Article GET IT
Times cited: 1293
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes & development. 2002 Academic Article GET IT
Times cited: 876
Identification of a conserved motif required for mTOR signaling. Current biology : CB. 2002 Academic Article GET IT
Times cited: 389
Coordinate regulation of translation by the PI 3-kinase and mTOR pathways. Advances in cancer research. 2002 Review GET IT
Times cited: 176
Characterization of regulatory events associated with membrane targeting of p90 ribosomal S6 kinase 1. Molecular and cellular biology. 2001 Academic Article GET IT
Times cited: 80
Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 430
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proceedings of the National Academy of Sciences of the United States of America. 2001 Academic Article GET IT
Times cited: 568
Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 2001 Review GET IT
Times cited: 410
The recruitment of Fas-associated death domain/caspase-8 in Ras-induced apoptosis. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 2001 Academic Article GET IT
Times cited: 25
Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 65
Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. The Journal of cell biology. 2001 Academic Article GET IT
Times cited: 499
Disruption of 3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 48
Essential role for caspase-8 in transcription-independent apoptosis triggered by p53. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 123
Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 55
Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 53
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity. 2000 Academic Article GET IT
Times cited: 697
Granulocyte-macrophage colony-stimulating factor stimulation results in phosphorylation of cAMP response element-binding protein through activation of pp90RSK. Blood. 2000 Academic Article GET IT
Times cited: 38
Rsk1 mediates a MEK-MAP kinase cell survival signal. Current biology : CB. 2000 Academic Article GET IT
Times cited: 251
FADD is required for multiple signaling events downstream of the receptor Fas. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 1999 Academic Article GET IT
Times cited: 165
Characterization of S6K2, a novel kinase homologous to S6K1. Oncogene. 1999 Academic Article GET IT
Times cited: 119
Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK. Current biology : CB. 1999 Academic Article GET IT
Times cited: 125
p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex. Molecular and cellular biology. 1999 Academic Article GET IT
Times cited: 168
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999 Academic Article GET IT
Times cited: 5463
Caspase-8 is required for cell death induced by expanded polyglutamine repeats. Neuron. 1999 Academic Article GET IT
Times cited: 373
The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins. Oncogene. 1998 Academic Article GET IT
Times cited: 52
Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. Current biology : CB. 1998 Academic Article GET IT
Times cited: 474
pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. Molecular and cellular biology. 1998 Academic Article GET IT
Times cited: 313
Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 94
STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Molecular and cellular biology. 1997 Academic Article GET IT
Times cited: 557
Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases. Oncogene. 1997 Academic Article GET IT
Times cited: 177
Neurotransmitter- and growth factor-induced cAMP response element binding protein phosphorylation in glial cell progenitors: role of calcium ions, protein kinase C, and mitogen-activated protein kinase/ribosomal S6 kinase pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1997 Academic Article GET IT
Times cited: 170
A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase. Oncogene. 1997 Academic Article GET IT
Times cited: 68
Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases. Molecular and cellular biology. 1997 Academic Article GET IT
Times cited: 282
A Drosophila gene structurally and functionally homologous to the mammalian 70-kDa s6 kinase gene. Proceedings of the National Academy of Sciences of the United States of America. 1996 Academic Article GET IT
Times cited: 28
A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Molecular and cellular biology. 1996 Academic Article GET IT
Times cited: 491
The serine protease inhibitors, tosylphenylalanine chloromethyl ketone and tosyllysine chloromethyl ketone, potently inhibit pp70s6k activation. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 30
Inhibition of p70/p85 S6 kinase activities in T cells by dexamethasone. Molecular endocrinology (Baltimore, Md.). 1996 Academic Article GET IT
Times cited: 17
The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell. 1996 Academic Article GET IT
Times cited: 234
YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites. Molecular and cellular biology. 1996 Academic Article GET IT
Times cited: 73
Studies of partially transforming polyomavirus mutants establish a role for phosphatidylinositol 3-kinase in activation of pp70 S6 kinase. Molecular and cellular biology. 1996 Academic Article GET IT
Times cited: 34
The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1. Cell. 1996 Academic Article GET IT
Times cited: 268
The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis. Molecular and cellular biology. 1996 Academic Article GET IT
Times cited: 82
Phosphorylation of c-Fos at the C-terminus enhances its transforming activity. Oncogene. 1996 Academic Article GET IT
Times cited: 148
Evidence for two catalytically active kinase domains in pp90rsk. Molecular and cellular biology. 1996 Academic Article GET IT
Times cited: 165
The p70S6K signalling pathway: a novel signalling system involved in growth regulation. Cancer surveys. 1996 Review GET IT
Times cited: 60
Structural and functional analysis of pp70S6k. Proceedings of the National Academy of Sciences of the United States of America. 1995 Academic Article GET IT
Times cited: 114
The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling. Current opinion in cell biology. 1995 Review GET IT
Times cited: 245
Dominant mutations confer resistance to the immunosuppressant, rapamycin, in variants of a T cell lymphoma. Cellular immunology. 1995 Academic Article GET IT
Times cited: 31
Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway. Molecular and cellular biology. 1995 Academic Article GET IT
Times cited: 150
The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 114
Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science (New York, N.Y.). 1995 Academic Article GET IT
Times cited: 525
Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. Molecular and cellular biology. 1995 Academic Article GET IT
Times cited: 158
Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 243
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature. 1994 Academic Article GET IT
Times cited: 658
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Molecular and cellular biology. 1994 Academic Article GET IT
Times cited: 1002
Activation of early growth response 1 gene transcription and pp90rsk during induction of monocytic differentiation. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 1994 Academic Article GET IT
Times cited: 18
Relationship between multiple biologic effects of rapamycin and the inhibition of pp70S6 protein kinase activity. Analysis in mutant clones of a T cell lymphoma. Journal of immunology (Baltimore, Md. : 1950). 1994 Academic Article GET IT
Times cited: 34
p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation. Molecular and cellular biology. 1994 Academic Article GET IT
Times cited: 104
Activation of MAP kinases, pp90rsk and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or Fc epsilon RI: rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells. European journal of immunology. 1993 Academic Article GET IT
Times cited: 69
Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase. Proceedings of the National Academy of Sciences of the United States of America. 1993 Academic Article GET IT
Times cited: 258
Subcellular localization specified by protein acylation and phosphorylation. Current opinion in cell biology. 1993 Review GET IT
Times cited: 36
Cytoplasmic to nuclear signal transduction by mitogen-activated protein kinase and 90 kDa ribosomal S6 kinase. Biochemical Society transactions. 1993 Review GET IT
Times cited: 27
A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. Molecular and cellular biology. 1993 Academic Article GET IT
Times cited: 233
Activation of the early growth response 1 gene and nuclear pp90rsk in human myeloid leukemia cells by 1-(beta-D-arabinofuranosyl)cytosine. Biochemistry. 1993 Academic Article GET IT
Times cited: 15
Functional domains and phosphorylation of the orphan receptor Nur77. Molecular endocrinology (Baltimore, Md.). 1993 Academic Article GET IT
Times cited: 118
Signal transduction via the MAP kinases: proceed at your own RSK. Proceedings of the National Academy of Sciences of the United States of America. 1993 Review GET IT
Times cited: 1159
Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 87
Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes. The Journal of biological chemistry. 1993 Academic Article GET IT
Times cited: 87
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature. 1992 Academic Article GET IT
Times cited: 568
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell. 1992 Academic Article GET IT
Times cited: 1033
ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell. 1992 Academic Article GET IT
Times cited: 662
Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Molecular and cellular biology. 1992 Academic Article GET IT
Times cited: 959
Growth-regulated signal transduction by the MAP kinases and RSKs. Cancer cells (Cold Spring Harbor, N.Y. : 1989). 1991 Review GET IT
Times cited: 40
Heat shock induces two distinct S6 protein kinase activities in quiescent mammalian fibroblasts. Journal of cellular physiology. 1991 Academic Article GET IT
Times cited: 42
Distinct mechanisms for the activation of the RSK kinases/MAP2 kinase/pp90rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 1991 Academic Article GET IT
Times cited: 80
Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity. Proceedings of the National Academy of Sciences of the United States of America. 1991 Academic Article GET IT
Times cited: 84
Coordinate regulation of pp90rsk and a distinct protein-serine/threonine kinase activity that phosphorylates recombinant pp90rsk in vitro. Molecular and cellular biology. 1991 Academic Article GET IT
Times cited: 49
Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transduction. Molecular and cellular biology. 1991 Academic Article GET IT
Times cited: 90
Identification of Xenopus S6 protein kinase homologs (pp90rsk) in somatic cells: phosphorylation and activation during initiation of cell proliferation. Molecular and cellular biology. 1990 Academic Article GET IT
Times cited: 112
Polyomavirus middle T antigen induces ribosomal protein S6 phosphorylation through pp60c-src-dependent and -independent pathways. Molecular and cellular biology. 1988 Academic Article GET IT
Times cited: 14
A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases. Proceedings of the National Academy of Sciences of the United States of America. 1988 Academic Article GET IT
Times cited: 199
Molecular analyses of gene products associated with the response of cells to mitogenic stimulation. Cold Spring Harbor symposia on quantitative biology. 1988 Academic Article GET IT
Times cited: 3
Identification of a ribosomal protein S6 kinase regulated by transformation and growth-promoting stimuli. The Journal of biological chemistry. 1987 Academic Article GET IT
Times cited: 47
Antibodies to Xenopus egg S6 kinase II recognize S6 kinase from progesterone- and insulin-stimulated Xenopus oocytes and from proliferating chicken embryo fibroblasts. Molecular and cellular biology. 1987 Academic Article GET IT
Times cited: 39
Role of second messengers in regulating the growth-associated S6 protein kinase activity. Progress in clinical and biological research. 1987 Academic Article GET IT
Times cited: 2
Regulation of protein kinase activities in PC12 pheochromocytoma cells. The EMBO journal. 1986 Academic Article GET IT
Times cited: 49
Stimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: dissociation from phorbol ester-stimulated activity. Proceedings of the National Academy of Sciences of the United States of America. 1986 Academic Article GET IT
Times cited: 36
Regulation of a ribosomal protein S6 kinase activity by the Rous sarcoma virus transforming protein, serum, or phorbol ester. Proceedings of the National Academy of Sciences of the United States of America. 1985 Academic Article GET IT
Times cited: 58
Phorbol ester, serum, and rous sarcoma virus transforming gene product induce similar phosphorylations of ribosomal protein S6. Proceedings of the National Academy of Sciences of the United States of America. 1984 Academic Article GET IT
Times cited: 47
Characterization of a transformation-sensitive protein in the extracellular matrix of chicken embryo fibroblasts. The Journal of biological chemistry. 1984 Academic Article GET IT
Times cited: 30
Phosphorylation of the ribosomal protein S6 is elevated in cells transformed by a variety of tumor viruses. Journal of virology. 1984 Academic Article GET IT
Times cited: 34
The effect of mannose6-phosphate on the turnover of cell surface glycosaminoglycans. Experimental cell research. 1983 Academic Article GET IT
Times cited: 16
Transformation-sensitive protein associated with the cell substratum of chicken embryo fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 1983 Academic Article GET IT
Times cited: 31
Detection of transformed cells using a fluorescent probe: the molecular basis for the differential reaction of fluorescamine with normal and transformed cells. Cytometry. 1982 Academic Article GET IT
Times cited: 4
Growth control in cultured 3T3 fibroblasts II. Molecular properties of a fraction enriched in growth inhibitory activity. The Journal of cell biology. 1982 Academic Article GET IT
Times cited: 27
Construction and characterization of a cDNA clone containing a portion of the bovine prolactin sequence. Nucleic acids research. 1980 Academic Article GET IT
Times cited: 13

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Funding awarded

Propionate metabolism and cancer awarded by National Cancer Institute Principal Investigator 2023 - 2028
The role of NAGK cysteine deprotonation in nutrient stress and cancer progression awarded by National Cancer Institute Principal Investigator 2023 - 2025
Signal Transduction to P70 S6 Kinase 1 awarded by National Institute of General Medical Sciences Principal Investigator 2020 - 2024
Mitogenic and Oncogenic Regulation of ERK/RSK Signaling awarded by National Cancer Institute Principal Investigator 2019 - 2024
Mitogenic and Oncogenic Regulation of ERK/RSK Signaling awarded by National Cancer Institute Principal Investigator 2019 - 2024
Establishing the role of Methylmalonic Acid in KRAS-mutated Lung Adenocarcinoma awarded by Conquer Cancer Foundation of the American Society of Clinical Oncology Principal Investigator 2022 - 2023
Addgene 706196 awarded by Addgene, Inc. Principal Investigator 2022 - 2023
Addgene 705684 awarded by Addgene, Inc. Principal Investigator 2022 - 2023

Targeting cysteine susceptibility in glioblastoma awarded by National Institute of Neurological Disorders & Stroke Key Personnel 2022 - 2027
Molecular and Translational Oncology Research awarded by National Cancer Institute Key Personnel 2017 - 2023

Targeting BRCA1-mutant breast cancer cells with folate and vitamin C awarded by Breast Cancer Research Foundation, Inc. Principal Investigator Subaward 2022 - 2023

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Background

education and training

Ph.D., Michigan State University 1983
B.A., University of California, Berkeley 1977

Contact

full name

John Blenis

primary email

job2064@med.cornell.edu

VIVO Weill Cornell Medical College

John Blenis Professor of Pharmacology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email