MK-801 attenuates cocaine induction of c-fos and preprodynorphin mRNA levels in Fischer rats. Academic Article uri icon

Overview

abstract

  • This study shows that single (15 mg/kg) or binge (3x15 mg/kg) cocaine administration increases c-fos mRNA levels, but only binge cocaine administration increases preprodynorphin mRNA levels in the caudate/putamen of Fischer rats. This increase in both c-fos and preprodynorphin mRNA levels is attenuated by the noncompetitive NMDA antagonist MK-801 (0.25 mg/kg), suggesting a preferential role for NMDA receptor co-activation in cellular events leading to cocaine-induced behaviors.

publication date

  • October 7, 2003

Research

keywords

  • Anesthetics, Local
  • Cocaine
  • Dizocilpine Maleate
  • Dynorphins
  • Gene Expression Regulation
  • Protein Precursors
  • Proto-Oncogene Proteins c-fos

Identity

Scopus Document Identifier

  • 1642395686

Digital Object Identifier (DOI)

  • 10.1016/s0169-328x(03)00319-x

PubMed ID

  • 14559159

Additional Document Info

volume

  • 117

issue

  • 2