PI3-kinase and TOR: PIKTORing cell growth. Review uri icon

Overview

abstract

  • Regulation of growth and proliferation in higher eukaryotic cells results from an integration of nutritional, energy, and mitogenic signals. Biochemical processes underlying cell growth and proliferation are governed by the phosphatidylinositol 3-kinase (PI3K) and target of rapamycin (TOR) signaling pathways. The importance of the interplay between these two pathways is underscored by the discovery that the TOR inhibitor rapamycin is effective against tumors caused by misregulation of the PI3K pathway. We review here recent data concerning the convergence of the PI3K and TOR pathways, the role of these pathways in cell growth and proliferation, and the regulation of growth by downstream TOR targets.

publication date

  • April 1, 2004

Research

keywords

  • Phosphatidylinositol 3-Kinases
  • Signal Transduction
  • Sirolimus

Identity

Scopus Document Identifier

  • 1342279422

Digital Object Identifier (DOI)

  • 10.1016/j.semcdb.2003.12.023

PubMed ID

  • 15209374

Additional Document Info

volume

  • 15

issue

  • 2