Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity. Academic Article uri icon

Overview

abstract

  • Histone deacetylase (HDAC) activity, commonly correlated with transcriptional repression, was essential for transcriptional induction of IFN-stimulated genes (ISG). Inhibition of HDAC function led to global impairment of ISG expression, with little effect on basal expression. HDAC function was not required for signal transducer and activator of transcription tyrosine phosphorylation, nuclear translocation, or assembly on chromatin, but it was needed for full activity of the signal transducer and activator of transcription transactivation domain. HDAC function was also required for gene induction driven by the IFN regulatory factor 3 transcription factor activated by virus infection, and it was essential for establishment of an antiviral response against Flaviviridae, Rhabdoviridae, and Picornaviridae. Requirement for HDAC function in transcriptional activation may represent a general mechanism for rapid stimulation of ISG transcription.

publication date

  • June 21, 2004

Research

keywords

  • Antiviral Agents
  • Gene Expression Regulation
  • Histone Deacetylases
  • Interferons

Identity

PubMed Central ID

  • PMC470717

Scopus Document Identifier

  • 3042752799

Digital Object Identifier (DOI)

  • 10.1073/pnas.0400567101

PubMed ID

  • 15210966

Additional Document Info

volume

  • 101

issue

  • 26