Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach. Academic Article uri icon

Overview

abstract

  • We describe a powerful new approach for discovering globally conserved regulatory elements between two genomes. The method is fast, simple and comprehensive, without requiring alignments. Its application to pairs of yeasts, worms, flies and mammals yields a large number of known and novel putative regulatory elements. Many of these are validated by independent biological observations, have spatial and/or orientation biases, are co-conserved with other elements and show surprising conservation across large phylogenetic distances.

publication date

  • January 26, 2005

Research

keywords

  • Genomics
  • Regulatory Elements, Transcriptional

Identity

PubMed Central ID

  • PMC551538

Scopus Document Identifier

  • 22344437987

Digital Object Identifier (DOI)

  • 10.1038/ng569

PubMed ID

  • 15693947

Additional Document Info

volume

  • 6

issue

  • 2