Effects of conformational stability and geometry of guanidinium display on cell entry by beta-peptides. Academic Article uri icon

Overview

abstract

  • We have used our ability to control beta-peptide secondary structure in order to explore the effects of conformational stability and geometry of guanidinium display on cell entry. Both of these factors affect the rate and relative amount of beta-peptide accumulation in the cytoplasm and nucleus of live HeLa cells. These beta-peptides do not show significant differences in cell surface binding, implying that structure and guanidinium display are important in a later step in cell entry than initial surface binding.

publication date

  • March 23, 2005

Research

keywords

  • Arginine
  • Guanidine
  • Oligopeptides

Identity

Scopus Document Identifier

  • 15744402961

Digital Object Identifier (DOI)

  • 10.1021/ja042566j

PubMed ID

  • 15771489

Additional Document Info

volume

  • 127

issue

  • 11