Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries. Review uri icon

Overview

abstract

  • Natural products provide the inspiration for a variety of strategies used in the diversity-oriented synthesis of novel small-molecule libraries. These libraries can be based on core scaffolds from individual natural products, specific substructures found across a class of natural products, or general structural characteristics of natural products. An increasing body of evidence supports the effectiveness of these strategies for identifying new biologically active molecules. Moreover, these efforts have led to significant advances in synthetic organic chemistry. Larger-scale evaluation of these approaches is on the horizon, using screening data that will be made publicly available in the new PubChem database.

publication date

  • June 1, 2005

Research

keywords

  • Biological Factors
  • Combinatorial Chemistry Techniques
  • Databases, Protein
  • Drug Design

Identity

Scopus Document Identifier

  • 20444410443

Digital Object Identifier (DOI)

  • 10.1016/j.cbpa.2005.03.006

PubMed ID

  • 15939326

Additional Document Info

volume

  • 9

issue

  • 3