Tan, Derek S

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Cheminformatic analysis of natural product-based drugs and chemical probes. Natural product reports. 2022 Review GET IT
Times cited: 12
Engineering CAR-T cells to activate small-molecule drugs in situ. Nature chemical biology. 2021 Academic Article GET IT
Times cited: 21
Defining new chemical space for drug penetration into Gram-negative bacteria. Nature chemical biology. 2020 Review GET IT
Times cited: 41
Gram-scale preparation of the antibiotic lead compound salicyl-AMS, a potent inhibitor of bacterial salicylate adenylation enzymes. Methods in enzymology. 2020 Academic Article GET IT
Total Synthesis of the Bacterial Diisonitrile Chalkophore SF2768. Organic letters. 2019 Academic Article GET IT
Times cited: 7
Structural basis for adenylation and thioester bond formation in the ubiquitin E1. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 31
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nature communications. 2019 Academic Article GET IT
Times cited: 68
Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction. Chemical communications (Cambridge, England). 2019 Academic Article GET IT
Times cited: 6
Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa. ACS chemical biology. 2019 Academic Article GET IT
Times cited: 2
Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors. The Journal of antibiotics. 2019 Review GET IT
Times cited: 19
Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE. Biochemistry. 2019 Academic Article GET IT
Times cited: 4
Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents. Biochemistry. 2019 Academic Article GET IT
Times cited: 6
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. ACS central science. 2018 Academic Article GET IT
Times cited: 2288
Synthesis of Benzannulated Medium-ring Lactams via a Tandem Oxidative Dearomatization-Ring Expansion Reaction. Chemistry (Weinheim an der Bergstrasse, Germany). 2018 Academic Article GET IT
Times cited: 15
Synthesis of the hexacyclic triterpene core of the jujuboside saponins via tandem Wolff rearrangement-intramolecular ketene hetero-Diels-Alder reaction. Tetrahedron. 2018 Academic Article GET IT
Times cited: 6
Rapid assembly of the doubly-branched pentasaccharide domain of the immunoadjuvant jujuboside A via convergent B(C₆F₅)₃-catalyzed glycosylation of sterically-hindered precursors. Chemical communications (Cambridge, England). 2017 Academic Article GET IT
Times cited: 10
Family-level stereoselective synthesis and biological evaluation of pyrrolomorpholine spiroketal natural product antioxidants. Chemical science. 2017 Academic Article GET IT
Times cited: 11
Stereocontrolled Synthesis of Spiroketals: An Engine for Chemical and Biological Discovery. Israel journal of chemistry. 2017 Academic Article GET IT
Times cited: 5
Semisynthesis of Analogues of the Saponin Immunoadjuvant QS-21. Methods in molecular biology (Clifton, N.J.). 2017 Academic Article GET IT
Times cited: 9
Diastereoselective Synthesis of Highly Substituted Tetrahydrofurans by Pd-Catalyzed Tandem Oxidative Cyclization-Redox Relay Reactions Controlled by Intramolecular Hydrogen Bonding. The Journal of organic chemistry. 2016 Academic Article GET IT
Times cited: 10
Stereoselective Synthesis, Docking, and Biological Evaluation of Difluoroindanediol-Based MenE Inhibitors as Antibiotics. Organic letters. 2016 Academic Article GET IT
Times cited: 12
Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa. ACS chemical biology. 2016 Academic Article GET IT
Times cited: 34
Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes. Bioorganic & medicinal chemistry letters. 2016 Academic Article GET IT
Times cited: 7
Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis. Accounts of chemical research. 2016 Academic Article GET IT
Times cited: 53
Quillaja Saponin Variants with Central Glycosidic Linkage Modifications Exhibit Distinct Conformations and Adjuvant Activities. Chemical science. 2016 Academic Article GET IT
Times cited: 28
Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents. Biochemistry. 2015 Academic Article GET IT
Times cited: 25
Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of Quillaja saponin vaccine adjuvants. Chemical communications (Cambridge, England). 2015 Academic Article GET IT
Times cited: 11
Correction: Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of Quillaja saponin vaccine adjuvants. Chemical communications (Cambridge, England). 2015 Article GET IT
Cheminformatic comparison of approved drugs from natural product versus synthetic origins. Bioorganic & medicinal chemistry letters. 2015 Academic Article GET IT
Times cited: 108
Principal component analysis as a tool for library design: a case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries. Methods in molecular biology (Clifton, N.J.). 2015 Academic Article GET IT
Times cited: 27
Design, synthesis, and immunologic evaluation of vaccine adjuvant conjugates based on QS-21 and tucaresol. Bioorganic & medicinal chemistry. 2014 Academic Article GET IT
Times cited: 26
General platform for systematic quantitative evaluation of small-molecule permeability in bacteria. ACS chemical biology. 2014 Academic Article GET IT
Times cited: 88
5-(Methylthio)tetrazoles as Versatile Synthons in the Stereoselective Synthesis of Polycyclic Pyrazolines via Photoinduced Intramolecular Nitrile Imine-Alkene 1,3-Dipolar Cycloaddition. Chemical science. 2014 Academic Article GET IT
Times cited: 17
Development of a minimal saponin vaccine adjuvant based on QS-21. Nature chemistry. 2014 Academic Article GET IT
Times cited: 67
Solvent-dependent divergent functions of Sc(OTf)₃ in stereoselective epoxide-opening spiroketalizations. Organic letters. 2014 Academic Article GET IT
Times cited: 21
Total synthesis, relay synthesis, and structural confirmation of the C18-norditerpenoid alkaloid neofinaconitine. Journal of the American Chemical Society. 2013 Academic Article GET IT
Times cited: 73
Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice. Antimicrobial agents and chemotherapy. 2013 Academic Article GET IT
Times cited: 44
Drug discovery: Diversifying complexity. Nature chemistry. 2013 Comment GET IT
Times cited: 63
Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion. Nature chemical biology. 2012 Academic Article GET IT
Times cited: 121
Stereoselective synthesis of acortatarins A and B. Organic letters. 2012 Academic Article GET IT
Times cited: 27
A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion. Nature chemical biology. 2012 Academic Article GET IT
Times cited: 116
Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesis. Chembiochem : a European journal of chemical biology. 2011 Academic Article GET IT
Times cited: 46
Hydrogen-bonding catalysis and inhibition by simple solvents in the stereoselective kinetic epoxide-opening spirocyclization of glycal epoxides to form spiroketals. Journal of the American Chemical Society. 2011 Academic Article GET IT
Times cited: 47
Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 36
The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis. Organic letters. 2010 Academic Article GET IT
Times cited: 47
Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective. Current opinion in chemical biology. 2010 Review GET IT
Times cited: 123
Active site remodelling accompanies thioester bond formation in the SUMO E1. Nature. 2010 Academic Article GET IT
Times cited: 151
Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes. Journal of the American Chemical Society. 2010 Academic Article GET IT
Times cited: 68
Stereoselective synthesis of benzannulated spiroketals: influence of the aromatic ring on reactivity and conformation. Organic letters. 2009 Academic Article GET IT
Times cited: 39
Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis. Bioorganic & medicinal chemistry letters. 2008 Academic Article GET IT
Times cited: 62
Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy. Chemical Society reviews. 2008 Review GET IT
Times cited: 26
Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation. Chemistry & biology. 2007 Academic Article GET IT
Times cited: 69
Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules. Journal of the American Chemical Society. 2007 Academic Article GET IT
Times cited: 36
A unified synthetic approach to polyketides having both skeletal and stereochemical diversity. Organic letters. 2007 Academic Article GET IT
Times cited: 40
Stereocontrolled synthesis of spiroketals via Ti(Oi-Pr)4-mediated kinetic spirocyclization of glycal epoxides with retention of configuration. Journal of the American Chemical Society. 2006 Academic Article GET IT
Times cited: 53
Total synthesis of guanacastepene a: a route to enantiomeric control. The Journal of organic chemistry. 2005 Academic Article GET IT
Times cited: 68
Stereocontrolled synthesis of spiroketals via a remarkable methanol-induced kinetic spirocyclization reaction. Journal of the American Chemical Society. 2005 Academic Article GET IT
Times cited: 57
Diversity-oriented synthesis: exploring the intersections between chemistry and biology. Nature chemical biology. 2005 Review GET IT
Times cited: 555
Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries. Current opinion in chemical biology. 2005 Review GET IT
Times cited: 117
Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis. Nature chemical biology. 2005 Academic Article GET IT
Times cited: 239
An acid-stable tert-butyldiarylsilyl (TBDAS) linker for solid-phase organic synthesis. Organic letters. 2005 Academic Article GET IT
Times cited: 30
Enantioselective synthesis of erythro-4-deoxyglycals as scaffolds for target- and diversity-oriented synthesis: new insights into glycal reactivity. Organic & biomolecular chemistry. 2005 Academic Article GET IT
Times cited: 40
Current progress in natural product-like libraries for discovery screening. Combinatorial chemistry & high throughput screening. 2004 Review GET IT
Times cited: 58
Discovery and applications of small molecule probes for studying biological processes. Biotechnology & genetic engineering reviews. 2004 Review GET IT
Times cited: 5
A stereoselective route to guanacastepene A through a surprising epoxidation. Angewandte Chemie (International ed. in English). 2002 Academic Article GET IT
Times cited: 71
Synthesis of the functionalized tricyclic skeleton of guanacastepene A: a tandem epoxide-opening beta-elimination/knoevenagel cyclization. Angewandte Chemie (International ed. in English). 2002 Academic Article GET IT
Times cited: 55
Sweet surrender to chemical genetics. Nature biotechnology. 2002 Article GET IT
Times cited: 19
Ligand discovery using encoded combinatorial libraries. Current opinion in drug discovery & development. 2000 Academic Article GET IT

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Research

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Funding awarded

Tri-Institutional PhD Program in Chemical Biology awarded by National Institute of General Medical Sciences Principal Investigator 2020 - 2025

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Background

education and training

Ph.D., Harvard University 2000
B.S., Stanford University 1995

Contact

full name

Derek S Tan

primary email

dst2001@med.cornell.edu

VIVO Weill Cornell Medical College

Derek S Tan Tri-Institutional Professor

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email