Interlinked fast and slow positive feedback loops drive reliable cell decisions. Academic Article uri icon

Overview

abstract

  • Positive feedback is a ubiquitous signal transduction motif that allows systems to convert graded inputs into decisive, all-or-none outputs. Here we investigate why the positive feedback switches that regulate polarization of budding yeast, calcium signaling, Xenopus oocyte maturation, and various other processes use multiple interlinked loops rather than single positive feedback loops. Mathematical simulations revealed that linking fast and slow positive feedback loops creates a "dual-time" switch that is both rapidly inducible and resistant to noise in the upstream signaling system.

publication date

  • October 21, 2005

Research

keywords

  • Cell Physiological Phenomena
  • Feedback, Physiological
  • Models, Biological
  • Signal Transduction

Identity

PubMed Central ID

  • PMC3175767

Scopus Document Identifier

  • 27144517984

Digital Object Identifier (DOI)

  • 10.1126/science.1113834

PubMed ID

  • 16239477

Additional Document Info

volume

  • 310

issue

  • 5747