Science (New York, N.Y.)

publication venue for

Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency. 2012
Autoimmunity to the modified self.. 379. 2023
Droplet-based forward genetic screening of astrocyte-microglia cross-talk.. 379. 2023
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.. 379. 2023
BTG1 mutation yields supercompetitive B cells primed for malignant transformation.. 379. 2023
Beyond the gut.. 377. 2022
Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets.. 376. 2022
Create a COVID-19 commission.. 374. 2021
Developmental chromatin programs determine oncogenic competence in melanoma.. 373. 2021
Diet-regulated production of PDGFcc by macrophages controls energy storage.. 373. 2021
Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity.. 373. 2021
Concrete steps to diversify the scientific workforce.. 372. 2021
QSER1 protects DNA methylation valleys from de novo methylation.. 372. 2021
Photochemical intermolecular dearomative cycloaddition of bicyclic azaarenes with alkenes.. 371. 2021
A mother's plea.. 371. 2021
De novo design of transmembrane β barrels.. 371. 2021
Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity.. 371. 2021
The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation.. 370. 2020
BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells.. 369. 2020
Modulating microbiome metabolites in vivo.. 369. 2020
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability.. 369. 2020
Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration.. 368. 2020
PIRs mediate innate myeloid cell memory to nonself MHC molecules.. 368. 2020
Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing.. 368. 2020
Intravital imaging of mouse embryos.. 368. 2020
Microenvironment mapping via Dexter energy transfer on immune cells.. 367. 2020
Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia.. 367. 2020
Depletion of microbiome-derived molecules in the host using Clostridium genetics.. 366. 2019
Lactose drives Enterococcus expansion to promote graft-versus-host disease.. 366. 2019
Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors.. 366. 2019
Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens.. 366. 2019
Laboratory mice born to wild mice have natural microbiota and model human immune responses.. 365. 2019
IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain.. 365. 2019
The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.. 364. 2019
Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response.. 364. 2019
Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation.. 364. 2019
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.. 364. 2019
T cell stemness and dysfunction in tumors are triggered by a common mechanism.. 363. 2019
High-fructose corn syrup enhances intestinal tumor growth in mice.. 363. 2019
Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis.. 363. 2019
Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition.. 363. 2019
AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate.. 363. 2019
Toward unrestricted use of public genomic data.. 363. 2019
Endothelial cell adaptation in regeneration.. 362. 2018
Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury.. 363. 2018
Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice.. 361. 2018
An intrinsic S/G₂ checkpoint enforced by ATR.. 361. 2018
Analysis of shared heritability in common disorders of the brain.. 360. 2018
Three-dimensional intact-tissue sequencing of single-cell transcriptional states.. 361. 2018
Improving support for young biomedical scientists.. 360. 2018
Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases.. 360. 2018
Bystander risk, social value, and ethics of human research.. 360. 2018
Neuronal-immune system cross-talk in homeostasis.. 359. 2018
β₂-adrenergic receptor-mediated negative regulation of group 2 innate lymphoid cell responses.. 359. 2018
Transcription-coupled changes in nuclear mobility of mammalian cis-regulatory elements.. 359. 2018
CX3CR1⁺ mononuclear phagocytes control immunity to intestinal fungi.. 359. 2018
Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma.. 359. 2018
Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy.. 359. 2017
Insurance for broad genomic tests in oncology.. 358. 2017
Gating of social reward by oxytocin in the ventral tegmental area.. 357. 2017
Natural polyreactive IgA antibodies coat the intestinal microbiota.. 358. 2017
The microanatomic segregation of selection by apoptosis in the germinal center.. 358. 2017
Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death.. 357. 2017
Mouse models of acute and chronic hepacivirus infection.. 357. 2017
Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity.. 356. 2017
Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance.. 355. 2017
SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer.. 355. 2017
Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation.. 353. 2016
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.. 352. 2016
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.. 352. 2016
Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo.. 352. 2016
HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1.. 352. 2016
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.. 351. 2016
The phenotypic legacy of admixture between modern humans and Neandertals.. 351. 2016
Negative local resistance caused by viscous electron backflow in graphene.. 351. 2016
Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut.. 351. 2016
Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction.. 351. 2016
Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism.. 351. 2016
Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior.. 351. 2016
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota.. 350. 2015
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.. 350. 2015
Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs.. 350. 2015
SOFT ROBOTICS. A 3D-printed, functionally graded soft robot powered by combustion.. 349. 2015
HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers.. 349. 2015
Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells.. 348. 2015
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.. 348. 2015
Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq.. 347. 2015
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.. 347. 2015
Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice.. 347. 2015
Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution.. 346. 2014
Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation.. 346. 2014
Mental health. Adolescent mental health--opportunity and obligation.. 346. 2014
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions.. 346. 2014
Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation.. 345. 2014
Controlling low rates of cell differentiation through noise and ultrahigh feedback.. 344. 2014
Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.. 344. 2014
Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma.. 343. 2014
Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome.. 343. 2014
Pregnenolone can protect the brain from cannabis intoxication.. 343. 2014
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide.. 342. 2013
High-speed force spectroscopy unfolds titin at the velocity of molecular dynamics simulations.. 342. 2013
Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer.. 342. 2013
Crystal structure of a soluble cleaved HIV-1 envelope trimer.. 342. 2013
Integrative annotation of variants from 1092 humans: application to cancer genomics.. 342. 2013
Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals.. 342. 2013
Transcription under torsion.. 340. 2013
Repeated cortico-striatal stimulation generates persistent OCD-like behavior.. 340. 2013
Multicompartment mesoporous silica nanoparticles with branched shapes: an epitaxial growth mechanism.. 340. 2013
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.. 340. 2013
A localized Wnt signal orients asymmetric stem cell division in vitro.. 339. 2013
Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO.. 339. 2013
EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent.. 338. 2012
Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis.. 339. 2012
An immunosurveillance mechanism controls cancer cell ploidy.. 337. 2012
Genome sequencing identifies a basis for everolimus sensitivity.. 338. 2012
Loss of the tumor suppressor BAP1 causes myeloid transformation.. 337. 2012
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.. 337. 2012
Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria.. 336. 2012
Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis.. 336. 2012
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.. 335. 2012
Fluorescence imaging of cellular metabolites with RNA.. 335. 2012
Interleukin-22 drives endogenous thymic regeneration in mice.. 336. 2012
A systematic survey of loss-of-function variants in human protein-coding genes.. 335. 2012
iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.. 335. 2012
Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice.. 334. 2011
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.. 334. 2011
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.. 334. 2011
An activating mutation of AKT2 and human hypoglycemia.. 334. 2011
RNA mimics of green fluorescent protein.. 333. 2011
The mutational landscape of head and neck squamous cell carcinoma.. 333. 2011
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.. 333. 2011
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.. 332. 2011
Structures of the bacterial ribosome in classical and hybrid states of tRNA binding.. 332. 2011
The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.. 332. 2011
Rapid pneumococcal evolution in response to clinical interventions.. 331. 2011
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project.. 330. 2010
BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program.. 330. 2010
Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist.. 330. 2010
Health care delivery. Open mHealth architecture: an engine for health care innovation.. 330. 2010
Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha.. 330. 2010
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.. 330. 2010
Stability of the regulatory T cell lineage in vivo.. 329. 2010
Prediction of individual brain maturity using fMRI.. 329. 2010
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.. 329. 2010
MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis.. 328. 2010
A genetic variant BDNF polymorphism alters extinction learning in both mouse and human.. 327. 2010
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner.. 326. 2009
Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target.. 326. 2009
Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium.. 325. 2009
Diversity and complexity in DNA recognition by transcription factors.. 324. 2009
Development of a second-generation antiandrogen for treatment of advanced prostate cancer.. 324. 2009
Human substantia nigra neurons encode unexpected financial rewards.. 323. 2009
In vivo analysis of dendritic cell development and homeostasis.. 324. 2009
Secondary replicative function of CD8+ T cells that had developed an effector phenotype.. 323. 2009
Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells.. 323. 2008
Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero.. 322. 2008
Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans.. 322. 2008
Induced pluripotent stem cells generated without viral integration.. 322. 2008
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.. 321. 2008
Seeding and propagation of untransformed mouse mammary cells in the lung.. 321. 2008
Whither or wither microbicides?. 321. 2008
Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin.. 321. 2008
Biochemistry. How enzymes work.. 320. 2008
Regulation of hepatic lipogenesis by the transcription factor XBP1.. 320. 2008
MeCP2, a key contributor to neurological disease, activates and represses transcription.. 320. 2008
AIDS/HIV. A STEP into darkness or light?. 320. 2008
Coordination of early protective immunity to viral infection by regulatory T cells.. 320. 2008
Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis.. 319. 2008
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.. 318. 2007
Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.. 316. 2007
A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis.. 316. 2007
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.. 316. 2007
Lymphotoxin beta receptor-dependent control of lipid homeostasis.. 316. 2007
Asymmetric T lymphocyte division in the initiation of adaptive immune responses.. 315. 2007
Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa.. 314. 2006
PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane.. 314. 2006
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior.. 314. 2006
Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels.. 314. 2006
Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice.. 313. 2006
The new era in cancer research.. 312. 2006
Interlinked fast and slow positive feedback loops drive reliable cell decisions.. 310. 2005
AIDS. Promote HIV chemoprophylaxis research, don't prevent it.. 309. 2005
The transcriptional landscape of the mammalian genome.. 309. 2005
Chromatic adaptation of photosynthetic membranes.. 309. 2005
Complete replication of hepatitis C virus in cell culture.. 309. 2005
A gene expression map for the euchromatic genome of Drosophila melanogaster.. 306. 2004
Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity.. 306. 2004
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.. 305. 2004
Overriding imatinib resistance with a novel ABL kinase inhibitor.. 305. 2004
Regulation of phagosome maturation by signals from toll-like receptors.. 304. 2004
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.. 304. 2004
G protein-coupled receptor-dependent development of human frontal cortex.. 303. 2004
A toll-like receptor that prevents infection by uropathogenic bacteria.. 303. 2004
Cross-linking cellular prion protein triggers neuronal apoptosis in vivo.. 303. 2004
Public health. A sound rationale needed for phase III HIV-1 vaccine trials.. 303. 2004
The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide.. 302. 2003
HCV persistence and immune evasion in the absence of memory T cell help.. 302. 2003
Public health. Grand Challenges in Global Health.. 302. 2003
Predominant autoantibody production by early human B cell precursors.. 301. 2003
VDAC2 inhibits BAK activation and mitochondrial apoptosis.. 301. 2003
Medicine. The need for a global HIV vaccine enterprise.. 300. 2003
Transmission dynamics of the etiological agent of SARS in Hong Kong: impact of public health interventions.. 300. 2003
Mitochondrial dysfunction in the elderly: possible role in insulin resistance.. 300. 2003
Tumor response to radiotherapy regulated by endothelial cell apoptosis.. 300. 2003
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis.. 300. 2003
Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.. 299. 2003
PDGFRA activating mutations in gastrointestinal stromal tumors.. 299. 2003
Subthalamic GAD gene therapy in a Parkinson's disease rat model.. 298. 2002
The genome sequence of the malaria mosquito Anopheles gambiae.. 298. 2002
BLM heterozygosity and the risk of colorectal cancer.. 297. 2002
Integrin-mediated long-term B cell retention in the splenic marginal zone.. 297. 2002
Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss.. 297. 2002
Parallel single-cell monitoring of receptor-triggered membrane translocation of a calcium-sensing protein module.. 295. 2002
Parthenogenetic stem cells in nonhuman primates.. 295. 2002
Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.. 295. 2002
Independent and redundant information in nearby cortical neurons.. 294. 2001
RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking.. 294. 2001
Regulation of cell survival by secreted proneurotrophins.. 294. 2001
Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.. 294. 2001
Tumor therapy with targeted atomic nanogenerators.. 294. 2001
Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation.. 294. 2001
Coupling of the TCR to integrin activation by Slap-130/Fyb.. 293. 2001
Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.. 293. 2001
Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer.. 292. 2001
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death.. 292. 2001
Information access. Building a "GenBank" of the published literature.. 291. 2001
Public health. Proliferation of National Institutes of Health.. 291. 2001
Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.. 290. 2000
Song replay during sleep and computational rules for sensorimotor vocal learning.. 290. 2000
Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells.. 290. 2000
Structural mechanism for STI-571 inhibition of abelson tyrosine kinase.. 289. 2000
Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor.. 289. 2000
Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model.. 288. 2000
The catalytic pathway of cytochrome p450cam at atomic resolution.. 287. 2000
One polypeptide with two aminoacyl-tRNA synthetase activities.. 287. 2000
In vivo protein transduction: delivery of a biologically active protein into the mouse.. 285. 1999
Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.. 284. 1999
Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation.. 284. 1999
HIV vaccines. Magic of the occult?. 283. 1999
Requirement for diverse, low-abundance peptides in positive selection of T cells.. 283. 1999
Force and velocity measured for single molecules of RNA polymerase.. 282. 1998
Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development.. 281. 1998
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.. 280. 1998
Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.. 279. 1998
Conversion of Bcl-2 to a Bax-like death effector by caspases.. 278. 1997
Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216.. 277. 1997
A cytoplasmic inhibitor of the JNK signal transduction pathway.. 277. 1997
Elementary calcium-release units induced by inositol trisphosphate.. 276. 1997
Crystal structure of the nucleotide exchange factor GrpE bound to the ATPase domain of the molecular chaperone DnaK.. 276. 1997
A member of the Frizzled protein family mediating axis induction by Wnt-5A.. 275. 1997
Role for the amino-terminal region of human TBP in U6 snRNA transcription.. 275. 1997
Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic.. 274. 1996
Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95.. 274. 1996
PIN: an associated protein inhibitor of neuronal nitric oxide synthase.. 274. 1996
Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance.. 274. 1996
Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide.. 273. 1996
Regulation of an early developmental checkpoint in the B cell pathway by Ig beta.. 272. 1996
C3d of complement as a molecular adjuvant: bridging innate and acquired immunity.. 271. 1996
Transcription against an applied force.. 270. 1995
Solution structure of a bovine immunodeficiency virus Tat-TAR peptide-RNA complex.. 270. 1995
The radius of gyration of an apomyoglobin folding intermediate.. 270. 1995
Jak-STAT signaling induced by the v-abl oncogene.. 269. 1995
CDC25 phosphatases as potential human oncogenes.. 269. 1995
A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP.. 269. 1995
Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells.. 269. 1995
Interaction of a peptidomimetic aminimide inhibitor with elastase.. 269. 1995
Requirement of serine phosphorylation for formation of STAT-promoter complexes.. 267. 1995
Through the glass lightly.. 267. 1995
Through the glass lightly.. 267. 1995
A functionally diverse enzyme superfamily that abstracts the alpha protons of carboxylic acids.. 267. 1995
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.. 266. 1994
Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody.. 266. 1994
Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking.. 264. 1994
Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis.. 264. 1994
Differential complementation of Bcr-Abl point mutants with c-Myc.. 264. 1994
Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma.. 262. 1993
Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase.. 261. 1993
CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase.. 260. 1993
Rescue of signaling by a chimeric protein containing the cytoplasmic domain of CD45.. 260. 1993
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting.. 260. 1993
Antibody-catalyzed degradation of cocaine.. 259. 1993
Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta.. 259. 1993
Science and the new administration.. 259. 1993
Mediation by G proteins of signals that cause collapse of growth cones.. 259. 1993
Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate.. 258. 1992
Inhibition of neutrophil chemokinesis on vitronectin by inhibitors of calcineurin.. 258. 1992
Production of the Alzheimer amyloid beta protein by normal proteolytic processing.. 258. 1992
Calmodulin trapping by calcium-calmodulin-dependent protein kinase.. 256. 1992
Cloning and characterization of inducible nitric oxide synthase from mouse macrophages.. 256. 1992
CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes.. 256. 1992
Tumor necrosis factor-alpha activates the sphingomyelin signal transduction pathway in a cell-free system.. 255. 1992
Cognitive and motor impairments associated with SIV infection in rhesus monkeys.. 255. 1992
Intracellular signaling by 14-hydroxy-4,14-retro-retinol.. 254. 1991
Structurally homologous ligand binding of integrin Mac-1 and viral glycoprotein C receptors.. 254. 1991
Suppression of the immune response by a soluble complement receptor of B lymphocytes.. 254. 1991
Response.. 253. 1991
Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo.. 252. 1991
Efficient incorporation of human CD4 protein into avian leukosis virus particles.. 250. 1990
Kinetics of gramicidin channel formation in lipid bilayers: transmembrane monomer association.. 250. 1990
Dissociation of gp120 from HIV-1 virions induced by soluble CD4.. 250. 1990
Down-regulation of LFA-1 adhesion receptors by C-myc oncogene in human B lymphoblastoid cells.. 250. 1990
Extrageniculate vision in hemianopic humans: saccade inhibition by signals in the blind field.. 250. 1990
Anatomy of a conformational change: hinged "lid" motion of the triosephosphate isomerase loop.. 249. 1990
Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis.. 249. 1990
Fibroblast growth factor receptor is a portal of cellular entry for herpes simplex virus type 1.. 248. 1990
Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination.. 248. 1990
Shared actions of endotoxin and taxol on TNF receptors and TNF release.. 248. 1990
Initiation by yeast RNA polymerase II at the adenoviral major late promoter in vitro.. 246. 1989
Transformation and plasmacytoid differentiation of EBV-infected human B lymphoblasts by ras oncogenes.. 243. 1989
Expression of functional nerve growth factor receptors after gene transfer.. 243. 1989
Development of disease and virus recovery in transgenic mice containing HIV proviral DNA.. 242. 1988
Repair of the secretion defect in the Z form of alpha 1-antitrypsin by addition of a second mutation.. 242. 1988
Cryopreservation, culture, and transplantation of human fetal mesencephalic tissue into monkeys.. 242. 1988
Insulin-stimulated release of lipoprotein lipase by metabolism of its phosphatidylinositol anchor.. 241. 1988
In situ transcription: specific synthesis of complementary DNA in fixed tissue sections.. 240. 1988
Reduction of naturally occurring motoneuron death in vivo by a target-derived neurotrophic factor.. 240. 1988
Highly cooperative opening of calcium channels by inositol 1,4,5-trisphosphate.. 240. 1988
A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation.. 240. 1988
Molecular crowding on the cell surface.. 239. 1988
Mutations in the first exon are associated with altered transcription of c-myc in Burkitt lymphoma.. 238. 1987
Physiological role of silent receptors of atrial natriuretic factor.. 238. 1987
Rapid stimulation of diacylglycerol production in Xenopus oocytes by microinjection of H-ras p21.. 238. 1987
Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon.. 238. 1987
Clonal gene therapy: transplanted mouse fibroblast clones express human alpha 1-antitrypsin gene in vivo.. 237. 1987
Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1+ B-cell subset.. 236. 1987
Characterization and clinical association of antibody inhibitory to HIV reverse transcriptase activity.. 235. 1987
Inhibition of secretion of hepatitis B surface antigen by a related presurface polypeptide.. 234. 1986
Oligodendrocyte adhesion activates protein kinase C-mediated phosphorylation of myelin basic protein.. 234. 1986
Human monoclonals from antigen-specific selection of B lymphocytes and transformation by EBV.. 234. 1986
Shock and tissue injury induced by recombinant human cachectin.. 234. 1986
Structure-activity studies of interleukin-2.. 234. 1986
Interleukin-2 induction of T-cell G1 progression and c-myb expression.. 233. 1986
Coronavirus infection induces H-2 antigen expression on oligodendrocytes and astrocytes.. 232. 1986
Biochemical and genetic evidence for the hepatitis B virus replication strategy.. 232. 1986
Calcium antagonist receptors in cardiomyopathic hamster: selective increases in heart, muscle, brain.. 232. 1986
Hyperacuity in cat retinal ganglion cells.. 231. 1986
Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting.. 230. 1985
Infection of the basal ganglia by a murine coronavirus.. 229. 1985
Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution.. 229. 1985
Naturally occurring antibodies reactive with sperm proteins: apparent deficiency in AIDS sera.. 228. 1985
Scintigraphy of normal mouse ovaries with monoclonal antibodies to ZP-2, the major zona pellucida protein.. 225. 1984
Immunoregulatory lymphokines of T hybridomas from AIDS patients: constitutive and inducible suppressor factors.. 225. 1984
The interleukin-2 T-cell system: a new cell growth model.. 224. 1984
Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage.. 224. 1984
Immunologic inhibition of ultraviolet radiation-induced tumor suppressor cell activity.. 224. 1984
Rectal insemination modifies immune responses in rabbits.. 224. 1984
Monoclonal antibody to Thy-1 enhances regeneration of processes by rat retinal ganglion cells in culture.. 224. 1984
Identification of pro-opiomelanocortin-derived peptides in the human adrenal medulla.. 221. 1983
Local cerebral blood flow increases during auditory and emotional processing in the conscious rat.. 221. 1983
Narcolepsy: biogenic amine deficits in an animal model.. 220. 1983
Expert Systems Research.. 220. 1983
Increased sensitivity of lymphocytes from people over 65 to cell cycle arrest and chromosomal damage.. 219. 1983
Extracts of skeletal muscle increase neurite outgrowth and cholinergic activity of fetal rat spinal motor neurons.. 219. 1983
Immunoreactive dynorphin-(1-8) and corticotropin- releasing factor in subpopulation of hypothalamic neurons.. 219. 1983
Myasthenic globulin enhances the loss of acetylcholine receptor clusters.. 219. 1983
Naloxone and ischemic neurologic deficits in the gerbil: is there an effect?. 218. 1982
Chemoprevention of neonatal jaundice: potency of tin-protoporphyrin in an animal model.. 217. 1982
Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction.. 217. 1982
Corticosterone: a critical factor in an opioid form of stress-induced analgesia.. 215. 1982
Tumor imaging with radioactive metal chelates conjugated to monoclonal antibodies.. 215. 1982
Molecular weight of human gamma interferon is similar to that of other human interferons.. 215. 1982
Reversal of induced ischemic neurologic deficit in gerbils by the opiate antagonist naloxone.. 215. 1982
Novel peptide neuronal system in rat brain and pituitary.. 214. 1981
Long-term stress-induced analgesia and activation of the opiate system.. 213. 1981
Elastin fragments attract macrophage precursors to diseased sites in pulmonary emphysema.. 212. 1981
Binding and mobility of the cell surface receptors for 3,3',5-triiodo-L-thyronine.. 211. 1981
Sexual dimorphism in extent of axonal sprouting in rat hippocampus.. 208. 1980
Cigarette smoking induces functional antiprotease deficiency in the lower respiratory tract of humans.. 206. 1979
Enkephalin-like material elevated in ventricular cerebrospinal fluid of pain patients after analgetic focal stimulation.. 201. 1978
Effects of naloxone on schizophrenia: reduction in hallucinations in a subpopulation of subjects.. 201. 1978
Adrenocorticotropin in rat brain: immunocytochemical localization in cells and axons.. 200. 1978
Behavioral neurochemistry: neuroregulators and behavioral states.. 200. 1978
Myotonic muscular dystrophy: altered calcium transport in erythrocytes.. 200. 1978
Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E.. 199. 1978
Potassium accumulation frog muscle: the association-induction hypothesis versus the membrane theory.. 198. 1977
Old problems, new challenges.. 198. 1977
Molecular graphics: application to the structure determination of a snake venom neurotoxin.. 197. 1977
H-y antigen: expression in human subjects with the testicular feminization syndrome.. 196. 1977
Field focusing nuclear magnetic resonance (FONAR): visualization of a tumor in a live animal.. 194. 1976
Effect of charcoal-broiled beef on phenacetin metabolism in man.. 194. 1976
Potassium accumulation in muscle: a test of the binding hypothesis.. 194. 1976
Long-term survival of skin allografts in mice treated with fractionated total lymphoid irradiation.. 193. 1976
Tin: a potent inducer of heme oxygenase in kidney.. 192. 1976
Letter: Gender identity and hermaphroditism.. 191. 1976
Intracellular distribution of free potassium in Chironomus salivary glands.. 188. 1975
Letter: Erythrocytes in human muscular dystrophy.. 188. 1975
Tryptoline formation by a preparation from brain with 5-methyltetrahydrofolic acid and tryptamine.. 187. 1975
Dopamine beta-hydroxylase activity in brains of chronic schizophrenic patients.. 187. 1975
Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism.. 186. 1974
Serum globulin in myasthenia gravis: inhibition of alpha-bungarotoxin binding to acetylcholine receptors.. 186. 1974
Phosphorylation of muscle membranes: identification of a membrane-bound protein kinase.. 182. 1973
Diphasic postsynaptic potential: a chemical synapse capable of mediating conjoint excitation and inhibition.. 176. 1972
Induction of benzo( )pyrene hydroxylase in human skin.. 176. 1972
Rapid increase of phenylethanolamine N-methyltransferase by environmental stress in an inbred mouse strains.. 175. 1972
DNA of Rous sarcoma virus: its nature and significance.. 175. 1972
Bilateral symmetry and interneuronal organization in the buccal ganglia of Aplysia.. 173. 1971
Transneuronal transfer of radioactivity in the central nervous system.. 172. 1971
Sexual behavior of male cats after administration of parachlorophenylalanine.. 170. 1970
"Hypersexuality" and behavioral changes in cats caused by administration of p-chlorophenylalanine.. 168. 1970
Brain norepinephrine: enhanced turnover after rubidium treatment.. 168. 1970
Proton magnetic resonance spectrum of polywater.. 167. 1970
Epinephrine metabolism in mammalian brain after intravenous and intraventricular administration.. 165. 1969
Decay of visual information from a single letter.. 158. 1967
Ultrastructure of thrombosthenin, the contractile protein of human blood platelets.. 157. 1967
Brain polysomes: response to environmental stimulation.. 157. 1967
Choline in the cell wall of a bacterium: novel type of polymer-linked choline in Pneumococcus.. 157. 1967
Transport of protein by goldfish optic nerve fibers.. 157. 1967
Neurological Mutants of the Mouse.. 150. 1965
GAMMA GLOBULIN: UNMASKING OF HIDDEN ANTIGENIC SITES ON LIGHT CHAINS.. 145. 1964
MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM.. 144. 1964
CONVULSANT DRUG ACTION ON NEURONALLY ISOLATED CEREBRAL CORTEX.. 142. 1963
Thyroxine: effects on amino acid incorporation into protein in vivo.. 140. 1963
Influence of invasiveness, hormones, and amphenone on steroids in adrenal carcinoma.. 124. 1956
Newsmaker interview: Harold Varmus. Piloting cancer research with a shrinking budget. Interview by Jocelyn Kaiser.. 333. 2011
Global health. Haiti's quake shifts clinic's focus from AIDS to aid. Interview by Jon Cohen.. 327. 2010
View from the top of a biomedical empire. Interview by Eliot Marshall.. 285. 1999
Varmus: the view from Bethesda. Interview by Eliot Marshall.. 262. 1993
Unlocking the secrets to Janus kinase activation. 2022
Immune imprinting in utero. 2021
Remembering seasonal coronaviruses. 2020
Drug modulation by nuclear condensates. 2020
Mitochondrial DNA promotes autoimmunity. 2019
A key ingredient for priming killer T cells. 2018
Response to Comment on "Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death". 2018
Response-Evaluating human trials: FDA's role. 2018
Bone voyage-Osteoblasts remotely control tumors. 2017
CELL SIGNALING. Seeing mTORC1 specificity. 2016
IMMUNOTHERAPY. Could microbial therapy boost cancer immunotherapy? 2015
CANCER. Cancer therapies that are gone with the Wnt. 2015
CELL SIGNALING. Lipids link ion channels and cancer. 2015
Immunology. Retroviral help for B cells. 2014
Virology. Getting rid of a persistent troublemaker to cure hepatitis. 2014
Structural biology. A new bundle of prospects for blocking HIV-1 entry. 2013
Biochemistry. A DNA twist diffuses and hops. 2012
Biochemistry. Visualizing amyloid assembly. 2012
Immunology. Rebuilding the thymus. 2012
Immunology. Amino acid addiction. 2009
Cancer. A few to flip the angiogenic switch. 2008
Comment on "Large-scale sequence analysis of avian influenza isolates". 2006
Microbiology. Weapons of microbial drug resistance abound in soil flora. 2006
Molecular biology. New Year's resolution--resolving resolvases. 2004
Immunology. Catalytic antibody bridges innate and adaptive immunity. 2002
Neurobiology. A glial spin on neurotrophins. 2002
Neuroscience. Windows into the human brain. 2002
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. 2001
Behavioral state modulation of auditory activity in a vocal motor system. 1998
On the other hand.. 1992
The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. 1991
Consent insufficient for data release-Response. 2019
Empowering young innovators. 2019
Turkey must end violent response to protests. 2013
U.S. basic research: delayed drug development. 2012
Low-dose radiation knowledge worth the cost. 2011
Speaking out about U.S. science output. 2007
A plea for justice for jailed medical workers. 2006
Role of iNOS in human host defense. 2006
Marketing drugs too early in testing. 2006
Support for the Human Cancer Genome Project. 2005
Neuroscience of stuttering. 2002
Research on resistance to cancer drug Gleevec. 2001
Forum for agricultural biotechnology debates. 2001
Threat to U.S. mouse colonies. 1999
Immediate release of crystallographic data: a proposal. 1998
Different subtypes of HIV-1 and cutaneous dendritic cells. 1997
AIDS: the process of discovery. 1997
Structural change mechanisms in regulatory proteins. 1996
Regulation of human gene therapy. 1995
An active National Institute of Mental Health. 1995
NIH review of gene therapy protocols. 1995
Embryo research guidelines. 1994
NIH R&D priorities. 1994
Delivery of Na+,K(+)-ATPase in polarized epithelial cells. 1993
Left-handed comments. 1992
Fibroblast growth factor receptor: does it have a role in the binding of herpes simplex virus? 1991
Receptor-mediated activation of immunodeficiency viruses in viral fusion. 1991
Fenfluramine studies. 1989
Human immunodeficiency viruses. 1986
Potassium accumulation frog muscle: the association-induction hypothesis versus the membrane theory. 1977
Molecular neurobiology--a conference sponsored by the NIMH. 1988
The transformation of oncology.. 352. 2016
The Internet and academic freedom.. 337. 2012
The enlightenment returns.. 323. 2009
Re-aim blame for NIH's hard times.. 312. 2006
Statement on scientific publication and security.. 299. 2003
Science and the control of AIDS.. 280. 1998
Cancer immunotherapy using checkpoint blockade. 2018
T cell exclusion, immune privilege, and the tumor microenvironment. 2015
Cell biology. Metabolic control of cell death. 2014
New paradigms in type 2 immunity. 2012
Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. 2011
Feedback loops shape cellular signals in space and time. 2008
Location, location, location: membrane targeting directed by PX domains. 2001
Lysophospholipids--receptor revelations. 2001
Arrested differentiation, the self-renewing memory lymphocyte, and vaccination. 2001
Autophagy as a regulated pathway of cellular degradation. 2000
Coreceptors: implications for HIV pathogenesis and therapy. 1997
The instructive role of innate immunity in the acquired immune response. 1996
Phosphoinositides as regulators in membrane traffic. 1996
Seeing the mind. 1993
Molecular analysis of protein assembly in muscle development. 1991
Morphogenesis of the polarized epithelial cell phenotype. 1989
Localization of cognitive operations in the human brain. 1988
Retroviruses. 1988
Interleukin-2: inception, impact, and implications. 1988
The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. 1988
Oncogenes and transcriptional control. 1987
Aromatic-aromatic interaction: a mechanism of protein structure stabilization. 1985
Form and function of retroviral proviruses. 1982
Metals as regulators of heme metabolism. 1977
Components of skilled performance. 1966

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