PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways. Review uri icon

Overview

abstract

  • The atypical protein kinase C (PKC) isoforms (aPKC) have been implicated in the regulation of a number of essential signaling events. Early studies using dominant-negative mutants suggested that they are important intermediaries in the activation of the canonical nuclear factor (NF)-kappaB pathway. More recent data using knockout mice genetically demonstrate that in fact the PKCzeta isoform is essential for the adequate activation of this cascade both upstream and downstream the IkappaB kinase complex. In this review, we summarize the mechanistic details whereby the aPKC pathway regulates important cellular functions and how this is achieved by the ability of these kinases to interact with different protein regulators and adapters, as well as to impinge in NF-kappaB-independent signaling cascades such as the Janus kinase-1/signal transducer and activator of transcription 6 system, which plays a critical role in T-cell-mediated hepatitis and asthma.

publication date

  • May 1, 2006

Research

keywords

  • NF-kappa B
  • Protein Kinase C
  • Protein-Tyrosine Kinases
  • STAT6 Transcription Factor
  • Signal Transduction

Identity

Scopus Document Identifier

  • 33645960166

Digital Object Identifier (DOI)

  • 10.1038/sj.cdd.4401823

PubMed ID

  • 16322752

Additional Document Info

volume

  • 13

issue

  • 5