Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland. Academic Article uri icon

Overview

abstract

  • The cellular localization of DARPP-32, a dopamine- and cyclic AMP-regulated phosphoprotein of 32 kD, enriched in dopamine-innervated brain regions, was investigated in the human parathyroid gland using indirect immunofluorescence histochemistry. Monoclonal antibodies were used to demonstrate DARPP-32-like immunoreactivity (LI) in chief cells of the normal human parathyroid gland and in cells of human parathyroid adenoma. Direct double-labelling revealed coexistence of DARPP-32-LI with parathyroid hormone (PTH)-LI. It has previously been demonstrated that dopamine D1-receptors are present in the parathyroid gland and that dopamine and D1-agonists stimulate the release of PTH. The present results suggest that DARPP-32 may play a role in the cellular mechanisms leading to dopamine-induced PTH secretion.

publication date

  • September 1, 1991

Research

keywords

  • Cyclic AMP
  • Dopamine
  • Nerve Tissue Proteins
  • Parathyroid Glands
  • Parathyroid Hormone
  • Phosphoproteins

Identity

Scopus Document Identifier

  • 0025991494

Digital Object Identifier (DOI)

  • 10.1007/BF03347888

PubMed ID

  • 1663529

Additional Document Info

volume

  • 14

issue

  • 8