Hemmings, Hugh C

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selected publications

Torture mechanisms and chronic somatic pain in US refugees. British journal of anaesthesia. 2023 Letter GET IT
Corrigendum to 'The evolution of the British Journal of Anaesthesia: the first 100 years' [Br J Anaesth 2023; 130: 3-7]. British journal of anaesthesia. 2023 Article GET IT
Celebrating the first centenary of the British Journal of Anaesthesia: a century of discovery and dissemination. British journal of anaesthesia. 2023 Editorial Article GET IT
Times cited: 1
The evolution of the British Journal of Anaesthesia: the first 100 years. British journal of anaesthesia. 2022 Editorial Article GET IT
Times cited: 3
A Common Human Brain-Derived Neurotrophic Factor Polymorphism Leads to Prolonged Depression of Excitatory Synaptic Transmission by Isoflurane in Hippocampal Cultures. Frontiers in molecular neuroscience. 2022 Academic Article GET IT
Times cited: 815
Distinct effects of volatile and intravenous anaesthetics on presynaptic calcium dynamics in mouse hippocampal GABAergic neurones. British journal of anaesthesia. 2022 Academic Article GET IT
Times cited: 1
Relevance of Cortical and Hippocampal Interneuron Functional Diversity to General Anesthetic Mechanisms: A Narrative Review. Frontiers in synaptic neuroscience. 2022 Review GET IT
Times cited: 111
Effects of General Anesthetics on Synaptic Transmission and Plasticity. Current neuropharmacology. 2022 Review GET IT
Times cited: 6
Turning the page on 2021: an eventful year for the British Journal of Anaesthesia. British journal of anaesthesia. 2021 Editorial Article GET IT
Times cited: 1
Selective inhibition of gamma aminobutyric acid release from mouse hippocampal interneurone subtypes by the volatile anaesthetic isoflurane. British journal of anaesthesia. 2021 Academic Article GET IT
Times cited: 2
Isoflurane Suppresses Hippocampal High-frequency Ripples by Differentially Modulating Pyramidal Neurons and Interneurons in Mice. Anesthesiology. 2021 Academic Article GET IT
Times cited: 2
Preprints in perioperative medicine: immediacy for the greater good. British journal of anaesthesia. 2021 Editorial Article GET IT
Times cited: 2
Modulation of dendritic spines by protein phosphatase-1. Advances in pharmacology (San Diego, Calif.). 2020 Review GET IT
Times cited: 1
Further retractions of articles by Joachim Boldt. British journal of anaesthesia. 2020 Editorial Article GET IT
Times cited: 7
Excellence in editorials: fulfilling their critical role in the medical literature. British journal of anaesthesia. 2020 Editorial Article GET IT
Times cited: 2
Chronic pain diagnosis in refugee torture survivors: A prospective, blinded diagnostic accuracy study. PLoS medicine. 2020 Academic Article GET IT
Times cited: 7
A special issue on respiration and the airway: critical topics at a challenging time. British journal of anaesthesia. 2020 Editorial Article GET IT
Times cited: 2
Women in anaesthesia, a special issue of the British Journal of Anaesthesia. British journal of anaesthesia. 2020 Editorial Article GET IT
Times cited: 3
Isoflurane Modulates Hippocampal Cornu Ammonis Pyramidal Neuron Excitability by Inhibition of Both Transient and Persistent Sodium Currents in Mice. Anesthesiology. 2019 Academic Article GET IT
Times cited: 12
Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery. Trends in pharmacological sciences. 2019 Review GET IT
Times cited: 106
Role of specific presynaptic calcium channel subtypes in isoflurane inhibition of synaptic vesicle exocytosis in rat hippocampal neurones. British journal of anaesthesia. 2019 Academic Article GET IT
Times cited: 9
The good, the bad, and the ugly: the many faces of opioids. British journal of anaesthesia. 2019 Editorial Article GET IT
Times cited: 13
Differential Inhibition of Neuronal Sodium Channel Subtypes by the General Anesthetic Isoflurane. The Journal of pharmacology and experimental therapeutics. 2019 Academic Article GET IT
Times cited: 10
Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to Ca_V2.1 and Ca_V2.2 in Rat Midbrain Neurons. eNeuro. 2019 Academic Article GET IT
Times cited: 9
Change management: the British Journal of Anaesthesia in 2018. British journal of anaesthesia. 2019 Editorial Article GET IT
The many contributions of WW Mapleson to the British Journal of Anaesthesia. British journal of anaesthesia. 2018 Editorial Article GET IT
Times cited: 2
Bioblasts, anaesthesia, and power failure: rein in the excitement. British journal of anaesthesia. 2018 Editorial Article GET IT
Landmarks in UK anaesthesia. British journal of anaesthesia. 2017 Editorial Article GET IT
Times cited: 2
Thinking, fast and slow: highlights from the 2016 BJA seminar on anaesthetic neurotoxicity and neuroplasticity. British journal of anaesthesia. 2017 Editorial Article GET IT
Times cited: 26
Sodium channel subtypes are differentially localized to pre- and post-synaptic sites in rat hippocampus. The Journal of comparative neurology. 2017 Academic Article GET IT
Times cited: 10
Divergent effects of anesthetics on lipid bilayer properties and sodium channel function. European biophysics journal : EBJ. 2017 Review GET IT
Times cited: 14
Isoflurane modulates activation and inactivation gating of the prokaryotic Na⁺ channel NaChBac. The Journal of general physiology. 2017 Academic Article GET IT
Times cited: 14
Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 38
A global vision for the British Journal of Anaesthesia. British journal of anaesthesia. 2017 Editorial Article GET IT
Times cited: 2
The 2016 BJA/PGA special issue: a selection of six educational reviews. British journal of anaesthesia. 2016 Article GET IT
Times cited: 1
Relevance of Clinical Relevance. Anesthesiology. 2016 Letter GET IT
α2-Adrenergic Receptor and Isoflurane Modulation of Presynaptic Ca2+ Influx and Exocytosis in Hippocampal Neurons. Anesthesiology. 2016 Academic Article GET IT
Times cited: 20
2015 BJA/PGA Special Issue: a selection of nine educational reviews. British journal of anaesthesia. 2015 Editorial Article GET IT
Times cited: 2
Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca2+ influx, not Ca2+-exocytosis coupling. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 60
Activity-dependent depression of neuronal sodium channels by the general anaesthetic isoflurane. British journal of anaesthesia. 2015 Academic Article GET IT
Times cited: 21
Memory and awareness in anaesthesia. British journal of anaesthesia. 2015 Editorial Article GET IT
Times cited: 5
Information technology innovation: the power and perils of big data. British journal of anaesthesia. 2015 Editorial Article GET IT
Times cited: 19
The 2014 BJA/PGA special issue: a selection of six educational reviews. British journal of anaesthesia. 2014 Editorial Article GET IT
Times cited: 4
Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties. The Journal of general physiology. 2014 Academic Article GET IT
Times cited: 22
Sociosexual investigation in sexually experienced, hormonally manipulated male leopard geckos: relation with phosphorylated DARPP-32 in dopaminergic pathways. Journal of experimental zoology. Part A, Ecological genetics and physiology. 2014 Academic Article GET IT
Times cited: 2
NAP5: intraoperative awareness detected, and undetected. British journal of anaesthesia. 2014 Editorial Article GET IT
Times cited: 5
Consensus statement from the BJA Workshop on Cancer and Anaesthesia. British journal of anaesthesia. 2014 Editorial Article GET IT
Times cited: 74
Isoflurane reversibly destabilizes hippocampal dendritic spines by an actin-dependent mechanism. PloS one. 2014 Academic Article GET IT
Times cited: 25
Regulation of protein phosphatase 1I by Cdc25C-associated kinase 1 (C-TAK1) and PFTAIRE protein kinase. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 4
Special issue on anaesthesia and cancer. British journal of anaesthesia. 2014 Editorial Article GET IT
Times cited: 18
Phytochemicals perturb membranes and promiscuously alter protein function. ACS chemical biology. 2014 Academic Article GET IT
Times cited: 211
2013 BJA/PGA Special Issue: a selection of nine educational reviews. British journal of anaesthesia. 2013 Editorial Article GET IT
Times cited: 4
Increased risk of awareness under anesthesia: an issue of consciousness or of memory?. Anesthesiology. 2013 Editorial Article GET IT
Times cited: 3
Special issue on anaesthetic neurotoxicity and neuroplasticity. British journal of anaesthesia. 2013 Editorial Article GET IT
Times cited: 7
Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar. British journal of anaesthesia. 2013 Conference Paper GET IT
Times cited: 42
HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain. The Journal of pharmacology and experimental therapeutics. 2013 Academic Article GET IT
Times cited: 54
Vein visualization: patient characteristic factors and efficacy of a new infrared vein finder technology. British journal of anaesthesia. 2013 Academic Article GET IT
Times cited: 59
Presynaptic inhibition of the release of multiple major central nervous system neurotransmitter types by the inhaled anaesthetic isoflurane. British journal of anaesthesia. 2012 Academic Article GET IT
Times cited: 41
The 2012 BJA/PGA supplement: a selection of seven educational reviews. British journal of anaesthesia. 2012 Editorial Article GET IT
Times cited: 3
Sodium channels as targets for volatile anesthetics. Frontiers in pharmacology. 2012 Academic Article GET IT
Times cited: 15
Anaesthesia awareness: 3 years of progress. British journal of anaesthesia. 2012 Editorial Article GET IT
Times cited: 4
The 2011 BJA/PGA supplement: a selection of nine educational reviews. British journal of anaesthesia. 2011 Editorial Article GET IT
Times cited: 4
Beyond the dopamine receptor: regulation and roles of serine/threonine protein phosphatases. Frontiers in neuroanatomy. 2011 Academic Article GET IT
Times cited: 331
Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery. The Journal of general physiology. 2011 Academic Article GET IT
Times cited: 43
Sleep and anesthesia: the histamine connection. Anesthesiology. 2011 Editorial Article GET IT
Times cited: 5
The rivers of Lethe and Mnemosyne converge: propofol and memory consolidation. Anesthesiology. 2011 Letter GET IT
Times cited: 7
Regional differences in the effects of isoflurane on neurotransmitter release. Neuropharmacology. 2011 Academic Article GET IT
Times cited: 19
Are anaesthetics toxic to the brain?. British journal of anaesthesia. 2011 Review GET IT
Times cited: 133
The 2010 BJA/PGA supplement: a selection of 10 educational reviews. British journal of anaesthesia. 2010 Editorial Article GET IT
Times cited: 3
AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. The EMBO journal. 2010 Academic Article GET IT
Times cited: 56
Positively active: how local anesthetics work. Anesthesiology. 2010 Academic Article GET IT
Times cited: 4
Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS. Journal of neurochemistry. 2010 Academic Article GET IT
Times cited: 17
Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortex. Neuroscience. 2010 Academic Article GET IT
Times cited: 9
Bidirectional modulation of isoflurane potency by intrathecal tetrodotoxin and veratridine in rats. British journal of pharmacology. 2010 Academic Article GET IT
Times cited: 17
Case scenario: postoperative delirium in elderly surgical patients. Anesthesiology. 2010 Review GET IT
Times cited: 30
Introduction: 2009 BJA/PGA Supplement: a selection of eight reviews. British journal of anaesthesia. 2009 Editorial Article GET IT
Times cited: 3
Neurotoxicity of general anesthetics: cause for concern?. Anesthesiology. 2009 Review GET IT
Times cited: 74
Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8. Anesthesiology. 2009 Academic Article GET IT
Times cited: 41
Sodium channels and the synaptic mechanisms of inhaled anaesthetics. British journal of anaesthesia. 2009 Review GET IT
Times cited: 63
Between Clotho and Lachesis: how isoflurane seals neuronal fate. Anesthesiology. 2009 Editorial Article GET IT
Times cited: 6
Comparative effects of halogenated inhaled anesthetics on voltage-gated Na+ channel function. Anesthesiology. 2009 Academic Article GET IT
Times cited: 56
Nicotinic receptor-evoked hippocampal norepinephrine release is highly sensitive to inhibition by isoflurane. British journal of anaesthesia. 2009 Academic Article GET IT
Times cited: 16
Xenon and the pharmacology of fear. Anesthesiology. 2008 Editorial Article GET IT
Times cited: 5
Intrathecal veratridine administration increases minimum alveolar concentration in rats. Anesthesia and analgesia. 2008 Academic Article GET IT
Times cited: 15
Is a new paradigm needed to explain how inhaled anesthetics produce immobility?. Anesthesia and analgesia. 2008 Review GET IT
Times cited: 79
Galloping in full pursuit of the mechanism of anesthetic immobility. Anesthesiology. 2008 Editorial Article GET IT
Times cited: 1
Activation of brain protein phosphatase-1(I) following cardiac arrest and resuscitation involving an interaction with 14-3-3 gamma. Journal of neurochemistry. 2008 Academic Article GET IT
Times cited: 6
Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation. Metabolic brain disease. 2008 Academic Article GET IT
Times cited: 2
Noble meets nouveau: a shared anesthetic binding site for xenon and isoflurane on a glutamate receptor. Anesthesiology. 2007 Editorial Article GET IT
Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1. British journal of pharmacology. 2007 Academic Article GET IT
Times cited: 28
General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo. Neuropharmacology. 2007 Academic Article GET IT
Times cited: 39
Isoform-selective effects of isoflurane on voltage-gated Na+ channels. Anesthesiology. 2007 Academic Article GET IT
Times cited: 46
Isoflurane inhibits NaChBac, a prokaryotic voltage-gated sodium channel. The Journal of pharmacology and experimental therapeutics. 2007 Academic Article GET IT
Times cited: 39
Differential regulation of protein phosphatase-1(I) by neurabin. Biochemical and biophysical research communications. 2007 Academic Article GET IT
Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5. The Journal of biological chemistry. 2007 Academic Article GET IT
Times cited: 25
Phosphorylation of CREB and DARPP-32 during late LTP at hippocampal to prefrontal cortex synapses in vivo. Synapse (New York, N.Y.). 2007 Academic Article GET IT
Times cited: 27
The anxiety-like phenotype of 5-HT receptor null mice is associated with genetic background-specific perturbations in the prefrontal cortex GABA-glutamate system. Journal of neurochemistry. 2006 Academic Article GET IT
Times cited: 29
Do general anesthetics add up?. Anesthesiology. 2006 Editorial Article GET IT
Times cited: 7
D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex. Behavioural brain research. 2006 Academic Article GET IT
Times cited: 57
Emerging molecular mechanisms of general anesthetic action. Trends in pharmacological sciences. 2005 Review GET IT
Times cited: 412
Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: 4-aminopyridine-evoked release. The Journal of pharmacology and experimental therapeutics. 2005 Academic Article GET IT
Times cited: 32
Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: basal release. The Journal of pharmacology and experimental therapeutics. 2005 Academic Article GET IT
Times cited: 56
Volatile anaesthetic effects on phospholipid binding to synaptotagmin 1, a presynaptic Ca2+ sensor. British journal of anaesthesia. 2005 Academic Article GET IT
Times cited: 4
Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5). Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 48
The general anesthetic isoflurane depresses synaptic vesicle exocytosis. Molecular pharmacology. 2005 Academic Article GET IT
Times cited: 52
Distinct rat neurohypophysial nerve terminal populations identified by size, electrophysiological properties and neuropeptide content. Brain research. 2004 Academic Article GET IT
Times cited: 7
Rapamycin causes activation of protein phosphatase-2A1 and nuclear translocation of PCNA in CD4+ T cells. Biochemical and biophysical research communications. 2004 Academic Article GET IT
Times cited: 17
Depression by isoflurane of the action potential and underlying voltage-gated ion currents in isolated rat neurohypophysial nerve terminals. The Journal of pharmacology and experimental therapeutics. 2004 Academic Article GET IT
Times cited: 42
Abundance and location of DARPP-32 in striato-tegmental circuits of domestic chicks. Journal of chemical neuroanatomy. 2004 Academic Article GET IT
Times cited: 12
Anesthetic effects on glutamatergic neurotransmission: lessons learned from a large synapse. Anesthesiology. 2004 Editorial Article GET IT
Times cited: 8
Neuroprotection by Na+ channel blockade. Journal of neurosurgical anesthesiology. 2004 Review GET IT
Times cited: 17
Isoflurane and propofol inhibit voltage-gated sodium channels in isolated rat neurohypophysial nerve terminals. Molecular pharmacology. 2003 Academic Article GET IT
Times cited: 84
Selective depression by general anesthetics of glutamate versus GABA release from isolated cortical nerve terminals. The Journal of pharmacology and experimental therapeutics. 2003 Academic Article GET IT
Times cited: 81
Differential interaction of anaesthetics and antiepileptic drugs with neuronal Na+ channels, Ca2+ channels, and GABA(A) receptors. British journal of anaesthesia. 2003 Academic Article GET IT
Times cited: 89
Effects of isoflurane and propofol on glutamate and GABA transporters in isolated cortical nerve terminals. Anesthesiology. 2003 Academic Article GET IT
Times cited: 36
General anesthetics do not affect release of the neuropeptide cholecystokinin from isolated rat cortical nerve terminals. Anesthesiology. 2002 Academic Article GET IT
Times cited: 5
The effects of general anesthetics on norepinephrine release from isolated rat cortical nerve terminals. Anesthesia and analgesia. 2002 Academic Article GET IT
Times cited: 26
General anesthetic actions on norepinephrine, dopamine, and gamma-aminobutyric acid transporters in stably transfected cells. Anesthesia and analgesia. 2002 Academic Article GET IT
Times cited: 23
Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia. Archives of general psychiatry. 2002 Academic Article GET IT
Times cited: 148
Widespread inhibition of sodium channel-dependent glutamate release from isolated nerve terminals by isoflurane and propofol. Anesthesiology. 2001 Academic Article GET IT
Times cited: 88
Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Academic Article GET IT
Times cited: 160
Anesthetic properties of 4-iodopropofol: implications for mechanisms of anesthesia. Anesthesiology. 2001 Academic Article GET IT
Times cited: 27
Distribution of DARPP-32 immunoreactive structures in the quail brain: anatomical relationship with dopamine and aromatase. Journal of chemical neuroanatomy. 2001 Academic Article GET IT
Times cited: 32
Isoflurane pretreatment ameliorates postischemic neurologic dysfunction and preserves hippocampal Ca2+/calmodulin-dependent protein kinase in a canine cardiac arrest model. Anesthesiology. 2000 Academic Article GET IT
Times cited: 63
Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia. Neuropharmacology. 2000 Academic Article GET IT
Times cited: 28
Inhibition of voltage-dependent sodium channels by Ro 31-8220, a 'specific' protein kinase C inhibitor. FEBS letters. 2000 Academic Article GET IT
Times cited: 34
Differential effects of anesthetic and nonanesthetic cyclobutanes on neuronal voltage-gated sodium channels. Anesthesiology. 2000 Academic Article GET IT
Times cited: 44
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature. 1999 Academic Article GET IT
Times cited: 493
Effects of anticonvulsants on veratridine- and KCl-evoked glutamate release from rat cortical synaptosomes. Neuroscience letters. 1999 Academic Article GET IT
Times cited: 66
Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation. Biochemistry. 1999 Academic Article GET IT
Times cited: 74
Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro. The Journal of clinical endocrinology and metabolism. 1999 Academic Article GET IT
Times cited: 51
General anesthetic effects on protein kinase C. Toxicology letters. 1998 Review GET IT
Times cited: 31
Effects of intravenous general anesthetics on [3H]GABA release from rat cortical synaptosomes. Anesthesiology. 1998 Academic Article GET IT
Times cited: 44
Inhibition of presynaptic sodium channels by halothane. Anesthesiology. 1998 Academic Article GET IT
Times cited: 69
The dopaminergic innervation of the pigeon telencephalon: distribution of DARPP-32 and co-occurrence with glutamate decarboxylase and tyrosine hydroxylase. Neuroscience. 1998 Academic Article GET IT
Times cited: 73
Localization of dopamine D1 receptors and dopaminoceptive neurons in the chick forebrain. The Journal of comparative neurology. 1997 Academic Article GET IT
Times cited: 59
Effect of halothane on conventional protein kinase C translocation and down-regulation in rat cerebrocortical synaptosomes. British journal of anaesthesia. 1997 Academic Article GET IT
Times cited: 28
Effects of propofol on sodium channel-dependent sodium influx and glutamate release in rat cerebrocortical synaptosomes. Anesthesiology. 1997 Academic Article GET IT
Times cited: 83
A comparison: the efficacy of sevoflurane-nitrous oxide or propofol-nitrous oxide for the induction and maintenance of general anesthesia. Journal of clinical anesthesia. 1996 Academic Article GET IT
Times cited: 28
Inhibition by propofol of [3H]-batrachotoxinin-A 20-alpha-benzoate binding to voltage-dependent sodium channels in rat cortical synaptosomes. British journal of pharmacology. 1996 Academic Article GET IT
Times cited: 30
CHEB, a convulsant barbiturate, evokes calcium-dependent spontaneous glutamate release from rat cerebrocortical synaptosomes. Neuropharmacology. 1996 Academic Article GET IT
Times cited: 7
Activation of endogenous protein kinase C by halothane in synaptosomes. Anesthesiology. 1996 Academic Article GET IT
Times cited: 36
Stimulus-dependent phosphorylation of MacMARCKS, a protein kinase C substrate, in nerve termini and PC12 cells. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 23
Biochemical characterization of the stimulatory effects of halothane and propofol on purified brain protein kinase C. Anesthesia and analgesia. 1995 Academic Article GET IT
Times cited: 41
Inhibition by volatile anesthetics of endogenous glutamate release from synaptosomes by a presynaptic mechanism. Anesthesiology. 1995 Academic Article GET IT
Times cited: 124
DARPP-32 (dopamine and cAMP-regulated phosphoprotein, M(r) 32,000) is a membrane protein in the bovine parathyroid. FEBS letters. 1995 Academic Article GET IT
Times cited: 8
Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons. Neuron. 1995 Academic Article GET IT
Times cited: 475
Effects of halothane and propofol on purified brain protein kinase C activation. Anesthesiology. 1994 Academic Article GET IT
Times cited: 83
Specificity of protein kinase inhibitor peptides and induction of long-term potentiation. Proceedings of the National Academy of Sciences of the United States of America. 1994 Academic Article GET IT
Times cited: 96
Identification of the phosphorylation site for cAMP-dependent protein kinase on Na+,K(+)-ATPase and effects of site-directed mutagenesis. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 141
Distribution of protein phosphatase inhibitor-1 in brain and peripheral tissues of various species: comparison with DARPP-32. Journal of neurochemistry. 1992 Academic Article GET IT
Times cited: 55
Dopamine- and adenosine-3',5'-monophosphate (cAMP)-regulated phosphoprotein of 32 kDa (DARPP-32) in the adrenal gland: immunohistochemical localization. Journal of the autonomic nervous system. 1991 Academic Article GET IT
Times cited: 8
Dopamine- and adenosine-3':5'-monophosphate (cAMP)-regulated phosphoprotein of Mr 32,000 (DARPP-32) in the retina of cat, monkey and human. Neuroscience letters. 1991 Academic Article GET IT
Times cited: 10
Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland. Journal of endocrinological investigation. 1991 Academic Article GET IT
Times cited: 17
Immunocytochemical localization of phosphatase inhibitor-1 in rat brain. The Journal of comparative neurology. 1991 Academic Article GET IT
Times cited: 43
Phosphorylated Mr 32,000 dopamine- and cAMP-regulated phosphoprotein inhibits Na+,K(+)-ATPase activity in renal tubule cells. Proceedings of the National Academy of Sciences of the United States of America. 1991 Academic Article GET IT
Times cited: 91
Synthetic peptide analogs of DARPP-32 (Mr 32,000 dopamine- and cAMP-regulated phosphoprotein), an inhibitor of protein phosphatase-1. Phosphorylation, dephosphorylation, and inhibitory activity. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 87
Characterization in mammalian brain of a DARPP-32 serine kinase identical to casein kinase II. Journal of neurochemistry. 1990 Academic Article GET IT
Times cited: 61
ARPP-21, a cAMP-regulated phosphoprotein enriched in dopamine-innervated brain regions: tissue distribution and regulation of phosphorylation in rat brain. Neuroscience. 1990 Academic Article GET IT
Times cited: 20
Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II. The Journal of biological chemistry. 1989 Academic Article GET IT
Times cited: 139
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Amino acid sequence of ARPP-21B from bovine caudate nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1989 Academic Article GET IT
Times cited: 10
Dopamine- and cAMP-regulated phosphoprotein (DARPP-32) and dopamine DA1 agonist-sensitive Na+,K+-ATPase in renal tubule cells. Proceedings of the National Academy of Sciences of the United States of America. 1989 Academic Article GET IT
Times cited: 94
ARPP-21, a cyclic AMP-regulated phosphoprotein (Mr = 21,000) enriched in dopamine-innervated brain regions. Amino acid sequence of the site phosphorylated by cyclic AMP in intact cells and kinetic studies of its phosphorylation in vitro. The Journal of biological chemistry. 1989 Academic Article GET IT
Times cited: 24
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Purification and characterization of the protein from bovine caudate nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1989 Academic Article GET IT
Times cited: 23
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Immunocytochemical localization in rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1989 Academic Article GET IT
Times cited: 58
Inhibitors of protein phosphatase-1. Inhibitor-1 of bovine adipose tissue and a dopamine- and cAMP-regulated phosphoprotein of bovine brain are identical. European journal of biochemistry. 1989 Academic Article GET IT
Times cited: 18
Role of protein phosphorylation in neuronal signal transduction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1989 Review GET IT
Times cited: 151
Morphometrical evidence for a complex organization of tyrosine hydroxylase-, enkephalin- and DARPP-32-like immunoreactive patches and their codistribution at three rostrocaudal levels in the rat neostriatum. Neuroscience. 1988 Academic Article GET IT
Times cited: 19
DARPP-32, a dopamine- and cyclic AMP-regulated phosphoprotein in tanycytes of the mediobasal hypothalamus: distribution and relation to dopamine and luteinizing hormone-releasing hormone neurons and other glial elements. Neuroscience. 1988 Academic Article GET IT
Times cited: 76
Immunohistochemical evidence for the existence of a dopamine- and cyclic AMP-regulated phosphoprotein (DARPP-32) in brown adipose tissue of pigs. Proceedings of the National Academy of Sciences of the United States of America. 1988 Academic Article GET IT
Times cited: 22
DARPP-32 and phosphatase inhibitor-1, two structurally related inhibitors of protein phosphatase-1, are both present in striatonigral neurons. Journal of neurochemistry. 1988 Academic Article GET IT
Times cited: 38
DARPP-32 as a marker for D-1 dopaminoceptive cells in the rat brain: prenatal development and presence in glial elements (tanycytes) in the basal hypothalamus. Advances in experimental medicine and biology. 1988 Review GET IT
Times cited: 27
Dopamine-regulated protein phosphorylation in the basal ganglia. Advances in experimental medicine and biology. 1988 Review GET IT
Times cited: 4
Ontogeny of the dopamine and cyclic adenosine-3':5'-monophosphate-regulated phosphoprotein (DARPP-32) in the pre- and postnatal mouse central nervous system. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 1988 Academic Article GET IT
Times cited: 32
Development of a dopamine- and cyclic adenosine 3':5'-monophosphate-regulated phosphoprotein (DARPP-32) in the prenatal rat central nervous system, and its relationship to the arrival of presumptive dopaminergic innervation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1987 Academic Article GET IT
Times cited: 113
DARPP-32 in the ciliary epithelium of the eye: a neurotransmitter-regulated phosphoprotein of brain localizes to secretory cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1986 Academic Article GET IT
Times cited: 37
The hypothalamic arcuate nucleus-median eminence complex: immunohistochemistry of transmitters, peptides and DARPP-32 with special reference to coexistence in dopamine neurons. Brain research. 1986 Academic Article GET IT
Times cited: 222
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein: regional, tissue, and phylogenetic distribution. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1986 Academic Article GET IT
Times cited: 190
DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Primary structure and homology with protein phosphatase inhibitor-1. The Journal of biological chemistry. 1986 Academic Article GET IT
Times cited: 75
DARPP-32, a dopamine-regulated phosphoprotein. Progress in brain research. 1986 Review GET IT
Times cited: 22
Protein kinases and phosphoproteins in the nervous system. Research publications - Association for Research in Nervous and Mental Disease. 1986 Review GET IT
Times cited: 12
Protein kinases in the brain. Annual review of biochemistry. 1985 Review GET IT
Times cited: 394
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated neuronal phosphoprotein. I. Amino acid sequence around the phosphorylated threonine. The Journal of biological chemistry. 1984 Academic Article GET IT
Times cited: 62
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated neuronal phosphoprotein. II. Comparison of the kinetics of phosphorylation of DARPP-32 and phosphatase inhibitor 1. The Journal of biological chemistry. 1984 Academic Article GET IT
Times cited: 114
DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1. Nature. 1984 Academic Article GET IT
Times cited: 485
Mammalian brain phosphoproteins as substrates for calcineurin. The Journal of biological chemistry. 1984 Academic Article GET IT
Times cited: 145
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Purification and characterization of the phosphoprotein from bovine caudate nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1984 Academic Article GET IT
Times cited: 145
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1984 Academic Article GET IT
Times cited: 500

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Research

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Funding awarded

Synaptic Mechanisms of General Anesthetic Action awarded by National Institute of General Medical Sciences Principal Investigator 2020 - 2024
Synaptic Mechanisms of General Anesthetic Action awarded by National Institute of General Medical Sciences Principal Investigator 2020 - 2024

Mechanisms of anesthetic-induced synaptic plasticity awarded by National Institute of General Medical Sciences Key Personnel 2019 - 2024

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Background

education and training

M.D., Yale University School of Medicine 1987
Ph.D., Yale University 1987
B.S., Yale University 1978

Contact

full name

Hugh C Hemmings

primary email

hchemmi@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Hugh C Hemmings Senior Associate Dean for Research

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage